List of works by Thomas J Scriba

120. A Randomized Double-blind Trial Assessing the Efficacy of M72/AS01E Vaccine Against Pulmonary Tuberculosis Disease in Adults With Latent Mycobacterium tuberculosis Infection

article

A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis

scientific article published on 2 May 2017

A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis

scientific article published on 14 January 2016

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

scientific article

A Review and Proposed Approach to the Neutrophilic Dermatoses of Childhood

scientific article

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts.

scientific article published on 13 April 2018

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

scientific article

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

scientific article published on 17 September 2008

A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates

article

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

A novel blood test for tuberculosis prevention and treatment.

scientific article

A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults

scientific article published on 26 January 2012

A randomized clinical trial in adults and newborns in South Africa to compare the safety and immunogenicity of bacille Calmette-Guérin (BCG) vaccine administration via a disposable-syringe jet injector to conventional technique with needle and syrin

scientific article

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

scientific article

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

scientific article published on 8 February 2013

Allelic resolution NGS HLA typing of Class I and Class II loci and haplotypes in Cape Town, South Africa

scientific article published on 18 September 2018

Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening

scientific article published on 27 April 2020

Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers

scientific article published on July 2006

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

scientific article published on June 2017

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population

scientific article published on 8 September 2017

Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers

scientific article published on May 2016

Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses

scientific article published on 13 July 2016

Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles

scientific article

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

scientific article published on 12 December 2018

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

scientific article published on 29 January 2018

CD4 and CD8 T-cell responses to mycobacterial antigens in African children

scientific article

COMPASS identifies T-cell subsets correlated with clinical outcomes

scientific article

Can we predict tuberculosis cure? What tools are available?

scientific article published on 08 November 2018

Characterization of the South African HIV type 1 subtype C complete 5' long terminal repeat, nef, and regulatory genes

scientific article published on January 2002

Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis

scientific article

Comparison of haematology and biochemistry parameters in healthy South African infants with laboratory reference intervals

scientific article published on 4 December 2017

Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention.

scientific article

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

scientific article published on 18 July 2019

Correction: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

article published in 2011

Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis

scientific article

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 6 May 2016

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants

scientific article published on 05 December 2019

Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response

scientific article published on 17 July 2009

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy

scientific article published on 26 June 2019

Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes

scientific article published on 7 April 2015

Diagnostic Challenge of Tuberculosis Heterogeneity

scientific article published on 01 June 2018

Diagnostic accuracy of ESAT-6 free IGRA compared to QuantiFERON-TB Gold In-tube

scientific article published on 01 October 2019

Diagnostic performance of an optimized transcriptomic signature of risk of tuberculosis in cryopreserved peripheral blood mononuclear cells.

scientific article published on 6 November 2017

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

scientific article published on 30 August 2018

Differential Recognition of Mycobacterium tuberculosis-Specific Epitopes as a Function of Tuberculosis Disease History

scientific article

Differential leukocyte counting and immunophenotyping in cryopreserved ex vivo whole blood

scientific article published on 16 December 2014

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

scientific article published on 16 April 2019

Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response

scientific article

Dose Optimization of H56:IC31 Vaccine for TB Endemic Populations: A Double-Blind, Placebo-Controlled, Dose-Selection Trial

scientific article published on 01 January 2019

Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants

scientific article published in June 2011

Effect of isoniazid therapy for latent TB infection on QuantiFERON-TB gold in-tube responses in adults with positive tuberculin skin test results in a high TB incidence area: a controlled study

scientific article published on March 2014

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies

scientific article published in 2022

Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Infection

article

Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial

scientific article published on 10 November 2015

Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth

scientific article published on 14 July 2020

Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis

scientific article published on 29 October 2019

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

scientific article published on 19 June 2015

Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

scientific article published on 30 December 2015

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis.

scientific article published on 6 April 2018

Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection.

scientific article published in March 2018

Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences.

scientific article

H1:IC31 vaccination is safe and induces long-lived TNF-α(+)IL-2(+)CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: A randomized trial

scientific article

HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis

scientific article published in January 2012

HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria

scientific article

HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine

scientific article

HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound

scientific article

HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients

publication published on 30 June 2021

Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function

scientific article published on 08 July 2013

Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease

scientific article

Host blood RNA signatures predict the outcome of tuberculosis treatment.

scientific article published on 12 August 2017

Human Immunology of Tuberculosis

scientific article

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

scientific article published on 15 November 2011

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study

scientific article

Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses

scientific article

Identifying specificity groups in the T cell receptor repertoire

scientific article published on 21 June 2017

Immune Phenotype and Functionality of Mtb-Specific T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment

scientific article published on 02 March 2020

Immune correlates of tuberculosis disease and risk translate across species

scientific article published on 01 January 2020

Immunological biomarkers of tuberculosis

scientific article published on 08 April 2011

Immunological protection against tuberculosis.

scientific article published on October 2007

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

scientific article published on 22 March 2019

Impact of Xpert MTB/RIF rollout on management of tuberculosis in a South African community.

scientific article published on 27 November 2017

Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.

scientific article

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status

scientific article

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

scientific article

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

scientific article published on 17 August 2018

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.

scientific article published on 12 February 2013

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

scientific article published on 12 August 2019

Long-lasting tuberculous pleurisy.

scientific article published on 25 May 2017

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

scientific article published on 01 December 2021

Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns

scientific article published on 4 January 2013

MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria ⬇️

scientific article published on 14 October 2019

Maturation of innate responses to mycobacteria over the first nine months of life

scientific article

Metabolite changes in blood predict the onset of tuberculosis

scientific article published in Nature Communications

Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania

scientific article published on 31 July 2017

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

scientific article

Moving tuberculosis vaccines from theory to practice

scientific article published on 01 September 2019

Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines

scientific article published on 09 October 2020

Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state

scientific article published on 15 July 2019

Mycobacterium tuberculosis-specific CD4 T cells are the principal source of IFN-γ in QuantiFERON assays in healthy persons

scientific article published on 10 March 2015

Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation

scientific article

Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town, South Africa

scientific article published on November 2002

Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection

scientific article

Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria

scientific article

Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol.

scientific article published on 22 May 2019

Phase 2b Controlled Trial of M72/AS01 Vaccine to Prevent Tuberculosis

article

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

scientific article published on 22 August 2019

Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination

scientific article published on 5 October 2017

Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy

scientific article published on 31 July 2019

Precise identification of a human immunodeficiency virus type 1 antigen processing mutant

scientific article published on 15 November 2006

Predicting tuberculosis risk - Authors' reply

scientific article published in November 2016

Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis

scientific article published on 20 July 2011

Prevalence of latent TB infection and TB disease among adolescents in high TB burden countries in Africa: a systematic review protocol.

scientific article

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination.

scientific article published in July 2018

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

scientific article

Prospects for a vaccine to prevent HIV-related tuberculosis

scientific article published on 01 November 2018

Protection against tuberculosis by mucosal BCG administration

scientific article published on 01 February 2019

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

scientific article published on 20 December 2017

Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry

scientific article

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

scientific article published on 25 May 2020

Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC)

scientific article

Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis

scientific article published on 13 December 2012

Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells

scientific article published on 24 August 2015

Renewing the Fight Against TB with an Old Vaccine

scientific article published on 01 March 2020

Risk of Disease After Isoniazid Preventive Therapy for Mycobacterium tuberculosis Exposure in Young HIV-uninfected Children

scientific article

SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis

scientific article

Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial

scientific article published on 6 January 2017

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin (BCG) for Infants of HIV Infected Mothers: A Phase 2 Randomized Controlled Trial

scientific article

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

scientific article (publication date: 23 March 2013)

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial

scientific article

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

scientific article

Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting

scientific article published on 10 June 2015

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial.

scientific article published in April 2018

Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion

scientific article published on 16 April 2019

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa

scientific article published on 2 February 2018

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

scientific article

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study.

scientific article published on 16 February 2017

Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life

scientific article

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns

scientific article published on 17 June 2010

T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents

scientific article

T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination

scientific article published on 03 February 2021

T cells and adaptive immunity to Mycobacterium tuberculosis in humans

scientific article

T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 12 April 2016

T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation.

scientific article published on 22 March 2018

Teaching advanced flow cytometry in Africa: 10 years of lessons learned

scientific article

Temporal trends in the prevalence of Mycobacterium tuberculosis infection in South African adolescents

scientific article published on 01 May 2019

The CSF Immune Response in HIV-1-Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy

scientific article

The Cross-species Mycobacterial Growth Inhibition Assay (MGIA) Project 2010-2014.

scientific article published on 12 July 2017

The Role of Clinical Symptoms in the Diagnosis of Intrathoracic Tuberculosis in Young Children

scientific article

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes

scientific article published on 21 February 2017

The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines.

scientific article published on 10 March 2008

The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans

scientific article published on 28 August 2015

The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

scientific article published on 03 February 2014

The dynamics of QuantiFERON-TB gold in-tube conversion and reversion in a cohort of South African adolescents

scientific article

The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis

scientific article published in PLoS ONE

The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination

scientific article

The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses

scientific article published on 10 September 2014

The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial

scientific article published on 3 June 2015

Time to symptom resolution in young children treated for pulmonary tuberculosis

scientific article

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria

scientific article published in PLoS ONE

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection

scientific article (publication date: 25 July 2007)

Tuberculosis Vaccine Development: Progress in Clinical Evaluation

scientific article published on 30 October 2019

Tuberculosis vaccines and prevention of infection

scientific article

Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining

scientific article published on November 2005

Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells

scientific article published on 15 October 2007

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making

Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines

scientific article published on 30 May 2016

Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination.

scientific article published on 20 April 2018

Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans

scientific article published on 2 January 2013

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