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List of works by Shoukat Dedhar

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells ⬇️

scientific article published on September 13, 2010

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells ⬇️

scientific article published on December 1, 1980

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

scientific article published on 30 August 2016

Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

scientific article published on 21 December 2017

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

scientific article

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes ⬇️

scientific article published on February 1, 1990

An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth

scientific journal article

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells

scientific article

BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways ⬇️

scientific article

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

scientific article published on 14 October 2020

Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

scientific article published on January 2014

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production

scientific article published on 26 January 2015

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

scientific article published on 26 June 2015

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways ⬇️

scientific article published on April 14, 1998

Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.

scientific article published on April 2009

Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.

scientific article published in March 2006

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

scientific article published on 8 March 2018

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice

scientific article published on 06 December 2013

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

scientific article published on 17 July 2018

Divergence in patterns of invasion among subpopulations derived from a human carcinoma clone: roles of intercellular contacts and of cell-substratum adhesion

scientific article published on January 1, 1992

EXTH-44. ADDITION OF THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 TO TEMOZOLOMIDE EXTENDS SURVIVAL OF MICE BEARING ORTHOTOPIC GLIOBLASTOMAS

Effects of hematopoietic growth factors on nonhematopoietic cells

scientific article published on January 1, 1992

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells

scientific article published on 01 December 2005

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

scientific article published on 13 July 2017

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

scientific article published on 22 November 2011

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

scientific article published on 17 July 2019

Identification and characterization of a novel high-molecular-weight form of the integrin alpha 3 subunit

scientific article published on November 1, 1992

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

scientific article published on October 2013

Immunostaining of human brain capillaries by antibodies to very late antigens ⬇️

scientific article published on March 1, 1990

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

scientific article published on January 2013

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

scientific article published on 2 October 2013

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

scientific article published on 27 April 2015

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

scientific article published in May 2005

Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

scientific article published on May 2006

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism

scientific article published on 16 August 2019

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation

scientific article published on 25 January 2014

Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner ⬇️

scientific article published on November 27, 2001

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity ⬇️

scientific article published on January 2, 1998

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

scientific article

Integrin-linked kinase (ILK) in combination molecular targeting.

scientific article published on January 2004

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.

scientific article

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

scientific article published in September 2005

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models

scientific article

Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

scientific article published on May 2007

Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly.

scientific article published on July 2005

Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

scientific article published on 17 May 2012

Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.

scientific article published on April 2006

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration.

scientific article

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

scientific article published on 22 March 2010

Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.

scientific article published on February 2006

Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum ⬇️

scientific article

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

scientific article

Integrin-linked kinase regulates E-cadherin expression through PARP-1.

scientific article published on October 2008

Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.

scientific article published on 7 March 2008

Integrin-linked kinase regulates endothelial cell survival and vascular development.

scientific article published on September 2004

Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.

scientific article

Integrin-linked kinase regulates interphase and mitotic microtubule dynamics

scientific article published in 2013

Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption

scientific article published in May 2014

Integrin-linked kinase--essential roles in physiology and cancer biology.

scientific article published on October 2008

Integrin-linked kinase: not so 'pseudo' after all.

scientific article published on 23 May 2011

Integrin-mediated signal transduction in transgenic mouse models of human breast cancer.

scientific article published on 31 October 2003

Integrins and signal transduction

scientific article published on 01 January 1999

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

scientific article

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

scientific article

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

publication published on 01 January 2021

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v ⬇️

scientific article published on June 1, 1990

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

scientific article published on April 2007

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

scientific article published in October 2001

Mapping the integrin-linked kinase interactome using SILAC.

scientific article

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium

scientific article (publication date: 18 January 2006)

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

scientific journal article

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.

scholarly article

Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism

scientific article published on 13 June 2006

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

scientific article published on 20 August 2010

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.

scientific article published on July 2010

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

scientific article

Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line ⬇️

scientific article published on October 1, 1983

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

scientific article

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.

scientific article published on 9 February 2007

Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis.

scientific article

Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells ⬇️

scientific article published on November 25, 1981

Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix ⬇️

scientific article published on 01 November 1994

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

scientific article published on December 1998

Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.

scientific article published on April 2004

Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells

scientific article

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

scientific article published on 09 May 2019

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

scientific article

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

scientific article

Role of integrin-linked kinase in leukocyte recruitment.

scientific article published on 20 February 2002

Role of the integrin-linked kinase (ILK) in determining neuronal polarity

scientific journal article

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

scientific article published on 6 February 2012

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine ⬇️

scientific article published on 01 March 1978

Stat3 in mitosis: A new role in clustering excess centrosomes

scientific article published on 7 August 2017

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

scientific article

Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1

scientific article

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK).

scientific article

Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography

scientific article published on 07 March 2013

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

scientific article published on 14 May 2019

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

scientific article published on 3 December 2012

Targeting hypoxic response for cancer therapy

scientific article

Targeting hypoxic tumour cells to overcome metastasis.

scientific article

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.

scientific article published on 2 March 2010

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

scientific article published on 04 February 2017

The importance of integrin‐linked kinase in the regulation of bladder cancer invasion ⬇️

scientific article published on May 28, 2011

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

scientific article published on 10 July 2017

The mitotic functions of integrin-linked kinase.

scientific article published on June 2009

The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1 ⬇️

scientific article published on September 15, 1992

The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth.

scientific article

Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

scientific article published on 03 January 2007

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

scientific article

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK) ⬇️

scientific article published on July 23, 2007

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