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List of works by Andrew Munro

94 Redox characterisation of flavocytochrome P-450 BM3 from Bacillus megaterium ⬇️

scientific article published on 01 November 1997

95 Probing inter-domain electron transfer in a model flavocytochrome P-450 ⬇️

scientific article published on 01 November 1997

A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid

scientific article

A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

scientific article published on 12 March 2004

A stable tyrosyl radical in monoamine oxidase A.

scientific article published on 18 November 2004

An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

scientific article published on 16 November 2016

Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.

scientific article published on 20 August 2016

Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.

scientific article published in January 2007

Analysis of the oxidation of short chain alkynes by flavocytochrome P450 BM3

scientific article published on 23 March 2011

Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology

scientific article

Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase.

scientific article

Biochemical and structural insights into bacterial organelle form and biogenesis.

scientific article

Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.

scientific article

Biological diversity of cytochrome P450 redox partner systems

scientific article published on January 2015

Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions

scientific journal article

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.

scientific article published on 4 January 2017

Catalytically Self-Sufficient P450 CYP102 (Cytochrome P450 BM-3): Resonance Raman Spectral Characterization of the Heme Domain and of the Holoenzyme ⬇️

scientific article published on February 24, 1998

Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment.

scientific article

Characterization of Cupriavidus metallidurans CYP116B1 – A thiocarbamate herbicide oxygenating P450–phthalate dioxygenase reductase fusion protein ⬇️

scientific article published on March 21, 2012

Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology

scientific article published on 20 August 2018

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site.

scientific article published in January 2009

Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches

scientific article published on 17 April 2020

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.

scientific article published on June 2012

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

scientific article published on 22 January 2020

Conformational and Thermodynamic Control of Electron Transfer in Neuronal Nitric Oxide Synthase†

scientific article published on 06 April 2007

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

scientific article published on 16 June 2007

Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

scientific article published on 19 December 2016

Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode

scientific article published on 06 October 2006

Cytochrome P450 1A1 opens up to new substrates

scientific article published in Journal of Biological Chemistry

Cytochrome P450--redox partner fusion enzymes.

scientific article published on 30 August 2006

Cytochrome P450s: creating novel ligand sets.

scientific article

DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis

scientific article (publication date: 12 October 2007)

Demonstration that CobG, the monooxygenase associated with the ring contraction process of the aerobic cobalamin (vitamin B12) biosynthetic pathway, contains an Fe-S center and a mononuclear non-heme iron center.

scientific article

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

scientific article published on 23 July 2019

Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics

scientific article published on 21 November 2017

Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization ⬇️

scientific article published on December 1, 1992

Drug targeting of heme proteins in Mycobacterium tuberculosis.

scientific article published on 14 November 2016

Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding

scientific article published on 13 August 2017

Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.

scientific article

Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.

scientific article published in October 2004

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

scientific article published on 18 August 2017

Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.

scientific article

Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium

scientific journal article

Fatty Acid-Induced Alteration of the Porphyrin Macrocycle of Cytochrome P450 BM3 ⬇️

scientific article published on June 1, 1998

FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I ⬇️

scientific article published on October 21, 2010

Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.

scientific article

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

scientific article published on 12 March 2004

Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer

scientific article published on 22 September 2010

Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals.

scientific article

Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure.

scientific article

Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.

scientific article published on 7 February 2017

How do azoles inhibit cytochrome P450 enzymes? A density functional study.

scientific article published in December 2008

Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center. ⬇️

scientific article

Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interactions with ferredoxin

scientific article published on 23 February 2011

Imidazolyl Carboxylic Acids As Mechanistic Probes of Flavocytochrome P-450 BM3†

scientific article published on 01 November 1998

Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism.

scientific article

Interaction of nitric oxide with cytochrome P450 BM3.

scientific article published in December 2004

Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).

scientific article

Introduction. Quantum catalysis in enzymes: beyond the transition state theory paradigm

scientific article published on 12 July 2006

Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters, and nitroaromatic explosives

scientific article

Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis

scientific article published on 19 April 2006

Mechanistic probes of flavocytochrome P-450 BM3

scientific article published on 01 August 1998

MhuD from Mycobacterium tuberculosis: Probing a Dual Role in Heme Storage and Degradation

scientific article published on 11 September 2019

Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions.

scientific article published on 29 May 2013

Novel haem co-ordination variants of flavocytochrome P450BM3

scientific article

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

scientific article published in Scientific Reports

Overview on theoretical studies discriminating the two-oxidant versus two-state-reactivity models for substrate monoxygenation by cytochrome P450 enzymes

scientific article

Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.

scientific article published in November 2001

Production of alkenes and novel secondary products by P450 OleTJE using novel H2 O2 -generating fusion protein systems.

scientific article published in February 2017

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

scientific article

Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189.

scientific article published on 4 January 2005

Redox Control of the Catalytic Cycle of Flavocytochrome P-450 BM3 ⬇️

scientific article published on November 11, 1997

Resonance Raman scattering of cytochrome P450 BM3 and effect of imidazole inhibitors.

scientific article

Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase.

scientific article published on 19 May 2005

Roles of key active-site residues in flavocytochrome P450 BM3

scientific article

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.

scientific article

Special issue: Cytochrome P450 structure and function: introduction.

scientific article published on 5 April 2012

Strength of axial water ligation in substrate-free cytochrome P450s is isoform dependent.

scientific article published on 27 February 2014

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

scientific article (publication date: 27 January 2017)

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

scientific article

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

scientific article published on 03 August 2018

Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.

scientific article published on 31 October 2006

Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis

scientific article published on 01 January 2008

Structure and function of the cytochrome P450 peroxygenase enzymes.

scientific article published on 6 February 2018

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

scientific article published on 31 October 2019

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.

scientific article published on 19 July 2016

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

scientific article published on 27 February 2019

The Mycobacterium Tuberculosis Cytochromes P450: Physiology, Biochemistry & Molecular Intervention ⬇️

scientific article published on August 1, 2010

The Redox Properties of Ascorbate Peroxidase†

scientific article published on 20 June 2007

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection

scientific article

The TB structural genomics consortium: providing a structural foundation for drug discovery.

scientific article

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

scientific article published on 28 September 2005

The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity

scientific article

The interaction of eukaryotic cytochrome b5 with flavocytochrome P-450 BM3 from Bacillus megaterium ⬇️

scientific article published on August 1, 1998

The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex.

scientific article

The preponderance of P450s in the Mycobacterium tuberculosis genome.

scientific article

The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway

scientific article

Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.

scientific article

Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA.

scientific article published in May 2008

Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases.

scientific article published in June 2010

Use of high pressure to study elementary steps in P450 and nitric oxide synthase

scientific article published on 01 December 2001

What makes a P450 tick?

scientific article published on 26 January 2013

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