List of works - Hermen Overkleeft

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

scientific article published on 30 July 2009

Arg-Thz is a minimal substrate for the N(α),N(α)-arginyl methyltransferase involved in the biosynthesis of plantazolicin

scientific article published in November 2013

Chemical biology of antigen presentation by MHC molecules

scientific article

Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model

scientific article

Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells

scientific article

Cleavable Crosslinkers as Tissue Fixation Reagents for Proteomic Analysis

scientific article published on 22 January 2018

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

scientific article published on 7 February 2017

Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients

scientific article published on 31 October 2011

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

scientific article published on 24 August 2015

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

scientific article published on 26 April 2007

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

scientific article published on 22 February 2016

Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies

scientific article published on 26 November 2013

Efficient induction of antitumor immunity by synthetic toll-like receptor ligand-peptide conjugates

scientific article

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

scientific article published on 7 July 2016

From covalent glycosidase inhibitors to activity-based glycosidase probes.

scientific article published on 5 August 2014

Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic α-amylase

scientific article

Glycosphingolipids and insulin resistance

scientific article published on January 2011

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

scientific article published on 17 February 2018

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2

scientific article

Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease

scientific article

Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes

scientific article published on 4 May 2016

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

scientific article published on November 2007

Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants

scientific article

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

scientific article published on 28 October 2014

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

scientific article

Photochemical generation of six- and five-membered cyclic vinyl cations

scientific article published in March 2006

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

scientific article

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

scientific article

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

scientific article published on 23 December 2009

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

scientific article published on 28 August 2017

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

scientific article published in January 2009

Reciprocal chemical genetics for swift lead and target identification.

scientific article

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

scientific article

Regulation of immunoproteasome function in the lung

scientific article published on 19 May 2015

Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides

scientific article published in February 2007

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

scientific article

Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

scientific article published on 24 January 2017

The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides ⬇️

scientific article published on April 23, 2013

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

scientific article published on December 2012

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

scientific article

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.

scientific article

The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies

scientific article

Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.

scientific article published on 30 July 2003

Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule

scientific article

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

scientific article

List of works by Hermen Overkleeft

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

Arg-Thz is a minimal substrate for the N(α),N(α)-arginyl methyltransferase involved in the biosynthesis of plantazolicin

Chemical biology of antigen presentation by MHC molecules

Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model

Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells

Cleavable Crosslinkers as Tissue Fixation Reagents for Proteomic Analysis

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies

Efficient induction of antitumor immunity by synthetic toll-like receptor ligand-peptide conjugates

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

From covalent glycosidase inhibitors to activity-based glycosidase probes.

Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic α-amylase

Glycosphingolipids and insulin resistance

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2

Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease

Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

Photochemical generation of six- and five-membered cyclic vinyl cations

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Reciprocal chemical genetics for swift lead and target identification.

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

Regulation of immunoproteasome function in the lung

Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides ⬇️

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.

The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies

Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.

Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes