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List of works by Sjaak Neefjes

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

scientific article

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

scientific article

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells.

scientific article

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

scientific article

A splice variant of RILP induces lysosomal clustering independent of dynein recruitment

scientific article

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

scientific article published on 03 November 2020

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

scientific article

Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck.

scientific article published in January 2018

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation

scientific article

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer

article

Autophagy in MHC class II presentation: sampling from within

scientific article published on January 2007

Bacterial infections and cancer

scientific article published on 22 October 2018

Cell biology of antigen presentation ⬇️

scientific article published on February 1, 1993

Chaperoning antigen presentation by MHC class II molecules and their role in oncogenesis

scientific article

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

scientific article

Chemical and genetic control of IFNγ-induced MHCII expression

scientific article published on 18 July 2018

Chemical profiling of primary mesothelioma cultures defines subtypes with different expression profiles and clinical responses.

scientific article published on 24 October 2017

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

scientific article

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer

scientific article published on 03 January 2017

Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition

scientific article

Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors

scientific article published on 14 January 2019

Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance ⬇️

scientific article published on December 1, 2001

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article

Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules

scientific article

Cross-presentation by intercellular peptide transfer through gap junctions.

scientific article published on March 2005

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

scientific article

Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo

scientific article published on 01 November 1992

Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents

scientific article published on 16 October 2020

Drug Discovery Maps, a machine learning model, visualizes and predicts kinome-inhibitor interaction landscapes

scientific article published on 08 November 2018

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

scientific article

Dynein-mediated vesicle transport controls intracellular Salmonella replication

scientific article

ER contact sites direct late endosome transport

scientific article published on 06 October 2015

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review

scientific article

Fluorescent probes for proteolysis: tools for drug discovery

scientific article published on January 2004

Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL.

scientific article

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer

scientific article published on 10 August 2015

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

scientific article published on 04 March 2019

HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading ⬇️

scientific article published on December 1, 1997

Hierarchy of Epstein-Barr virus-specific cytotoxic T-cell responses in individuals carrying different subtypes of an HLA allele: implications for epitope-based antiviral vaccines ⬇️

scientific article published on October 1, 1997

Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis

scientific article published on 15 May 2019

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity.

scientific article published on 19 May 2017

In Vivo and In Vitro Modulation of HLA-DM and HLA-DO Is Induced by B Lymphocyte Activation ⬇️

scientific article published on December 15, 2001

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes ⬇️

scientific article published on February 1, 1992

Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b

scientific article published on 09 September 2020

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

scientific article

Loss of the GPI-anchor in B-lymphoblastic leukemia by epigenetic downregulation of PIGH expression

scientific article published on 25 November 2018

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

scientific article

MHC class I alleles and their exploration of the antigen-processing machinery

scientific article

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes ⬇️

scientific article published on August 1, 1995

Mechanical forces used for cell fractionation can create hybrid membrane vesicles ⬇️

scientific article published on October 20, 2010

Mechanisms of lysosomal positioning and movement

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation

scientific article published on 01 March 2019

Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm

scientific article published on August 2007

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis

scientific article

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

scientific article published on 20 November 2014

New insight into the everlasting host-pathogen arms race

scientific article published in August 2009

New insights into the activities and toxicities of the old anti-cancer drug doxorubicin

scientific article published on 06 October 2020

Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

scientific article published on 16 July 2016

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

scientific article

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer

scientific article

Phosphorylation of the oestrogen receptor alpha at serine 305 and prediction of tamoxifen resistance in breast cancer

scientific article

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes

scientific article published on 3 May 2016

Profiling proteasome activity in tissue with fluorescent probes

scientific article

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

scientific article published on 14 August 2015

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article published on 16 January 2018

Rab proteins, connecting transport and vesicle fusion

scientific article

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

scientific article published on 24 April 2006

Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae

scientific article published on 7 August 2013

Recombination-induced tag exchange to track old and new proteins

scientific article

Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release

publication published on 07 July 2021

RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.

scientific article published on June 2005

Routes to manipulate MHC class II antigen presentation

scientific article

SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport

scientific article published on 21 February 2020

Selective infection of antigen-specific B lymphocytes by Salmonella mediates bacterial survival and systemic spreading of infection

scientific article (publication date: 2012)

Spatiotemporal analysis of organelle and macromolecular complex inheritance

scientific article published on 17 December 2012

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model.

scientific article published on 18 May 2018

Statins affect cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomains

scientific article published on June 2005

TBC1D5 controls the GTPase cycle of Rab7b

scientific article published on 03 September 2018

The EGFR odyssey - from activation to destruction in space and time.

scientific article published on 27 November 2017

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors ⬇️

scientific article published on October 30, 2001

The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling

scientific article

The first step of peptide selection in antigen presentation by MHC class I molecules

scientific article

The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells

scientific article published in November 2010

The journey of Ca<sup>2+</sup> through the cell - pulsing through the network of ER membrane contact sites

scientific article published on 29 December 2020

The labyrinth unfolds: architectural rearrangements of the endolysosomal system in antigen-presenting cells

scientific article published on 07 February 2019

The many roads to cross-presentation

scientific article

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases

scientific article published on 14 June 2018

Towards an understanding of C9orf82 protein/CAAP1 function

scientific article published in PLoS ONE

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates

scientific article published on 27 June 2018

Tumor-type specific intracellular bacteria are undetectable in human breast cancer cells ⬇️

2023 eLetter in Science by de Miranda et al

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

scientific article published on 29 March 2019

Ubiquitin crosstalk connecting cellular processes

scientific article

Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1* ⬇️

scientific article published on January 8, 2013

Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens

scientific article published on 05 June 2018

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

scientific article

Visualizing the action of steroid hormone receptors in living cells

scientific article published on 9 March 2007

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