List of works by Frank J. Gunn-Moore

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells

scientific article

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

scientific article published in December 2018

6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation.

scientific article published on 9 January 2017

A Direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the progression and treatment of Alzheimer`s disease.

scientific article

A compact Airy beam light sheet microscope with a tilted cylindrical lens.

scientific article

A functional FERM domain binding motif in neurofascin

scientific journal article

A multimodal holographic system for optical manipulation and injection of developing embryos

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.

scientific article

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

scientific article

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

scientific article published on 11 December 2015

All-Optical Assay to Study Biological Neural Networks

scientific article published on 05 July 2018

Alzheimer's disease in humans and other animals: A consequence of postreproductive life span and longevity rather than aging.

scientific article published on 30 September 2017

Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation.

scientific article

Application of dynamic diffractive optics for enhanced femtosecond laser based cell transfection

scientific article

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

scientific article published on 25 June 2019

Automated laser guidance of neuronal growth cones using a spatial light modulator.

scientific article

Benzothiazoles - scaffold of interest for CNS targeted drugs.

scientific article

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment

scientific article published on 17 March 2020

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

scientific article

Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells.

scientific article published on 18 April 2016

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

scientific article published on 21 September 2008

Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma

scientific article

Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

scientific article published on 9 October 2007

Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.

scientific article published on 21 December 2009

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment

scientific article published on 30 May 2016

Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis

scientific article

Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma

scientific article

Endophilin I expression is increased in the brains of Alzheimer disease patients

scientific article

Enhanced Optical Manipulation of Cells Using Antireflection Coated Microparticles

article

Enhanced cell transfection using subwavelength focused optical eigenmode beams [Invited]

Enhanced operation of femtosecond lasers and applications in cell transfection

scientific article

Enhancement and optimization of plasmid expression in femtosecond optical transfection.

scientific article published on 13 January 2011

Enhancement of the efficiency of femtosecond optical transfection

Exploring the ultrashort pulse laser parameter space for membrane permeabilisation in mammalian cells

scientific article

Fabrication of polymer microlens at the apex of optical fiber

Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation

scientific article

Femtosecond laser pulses for chemical-free embryonic and mesenchymal stem cell differentiation

Femtosecond optical injection of intact plant cells using a reconfigurable platform

article

Femtosecond optical transfection of individual mammalian cells.

scientific article

Femtosecond optoinjection of intact tobacco BY-2 cells using a reconfigurable photoporation platform.

scientific article published on 14 November 2013

Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression

scientific article published in October 2015

Friend or enemy? Review of 17β-HSD10 and its role in human health or disease

scientific article published on 19 April 2020

Generation and control of multiple Bessel beams for optical micromanipulation

Generation of multiple Bessel beams for a biophotonics workstation.

scientific article

Growing Old is Not for Wimps ⬇️

scientific article published on 01 November 2010

High-throughput optical injection of mammalian cells using a Bessel light beam

scientific article

High-throughput optical injection of mammalian cells using a non-diffracting beam in a microfluidic platform

Holographic approach for optical poration and trapping of developing embryos

Imaging the cellular response to transient shear stress using stroboscopic digital holography

scientific article published in December 2011

Imaging the cellular response to transient shear stress using time-resolved digital holography

In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer's Disease

scientific article published on 17 March 2017

Increasing the resolution of light sheet microscopy in the presence of aberrations

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease

scientific article

Integrated 3D macro-trapping and light-sheet imaging system

Integrated holographic system for all-optical manipulation of developing embryos. ⬇️

scientific article

Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model

scientific article

Interference-free superposition of nonzero order light modes: Functionalized optical landscapes

Intracellular Dielectric Tagging for Improved Optical Manipulation of Mammalian Cells

Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?

scientific article published on January 2013

KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals

scientific article published on 21 May 2012

Laser-induced breakdown of an optically trapped gold nanoparticle for single cell transfection.

scientific article

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.

scientific article

Light forces the pace: optical manipulation for biophotonics

scientific article published on July 2010

Light sheet fluorescence microscopy for neuroscience

scientific article published on 23 July 2018

Light-sheet microscopy using an Airy beam.

scientific article published on 6 April 2014

Light-sheet microscopy with attenuation-compensated propagation-invariant beams.

scientific article published on 6 April 2018

Macro-optical trapping for sample confinement in light sheet microscopy

scientific article published on 8 July 2015

Mitochondrial β-amyloid in Alzheimer's disease.

scientific article published in August 2011

Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.

scientific article published on 16 December 2010

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

scientific article published on 10 August 2007

Morphology-Specific Inhibition of β-Amyloid Aggregates by 17β-Hydroxysteroid Dehydrogenase Type 10.

scientific article published on 25 April 2016

Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells.

scientific article

Nanostructural Diversity of Synapses in the Mammalian Spinal Cord

scientific article published on 18 May 2020

Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction

scientific article (publication date: 5 February 2002)

Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function

scientific article published on 11 March 2020

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment

scientific article published on 29 July 2019

Optical Sculpting: Shaping the Future of Biophotonic

Optical injection of mammalian cells using a microfluidic platform

scientific article

Optical sculpting: trapping through disorder and transfer of orbital angular momentum

Optical transfection of mammalian cells

article

Optical transfection using an endoscope-like system

scientific article

Optical trapping and fluorescence excitation with violet diode lasers and extended cavity surface emitting lasers

scientific article

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer's disease

scientific article published in Nature Communications

Photo-transfection of mammalian cells via femtosecond laser pulses

Phototransfection of mammalian cells using femtosecond laser pulses: optimization and applicability to stem cell differentiation

scientific article

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system

scientific article

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment

scientific article published on 21 February 2011

Quantitative phase study of the dynamic cellular response in femtosecond laser photoporation

scientific article

RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

scientific article published on 28 March 2008

Realization of curved Bessel beams: propagation around obstructions

scientific article

Single cell optical transfection

scientific article

Single cell transfection by laser-induced breakdown of an optically trapped gold nanoparticle

Spatially optimized gene transfection by laser-induced breakdown of optically trapped nanoparticles

article

Structured illumination microscopy as a diagnostic tool for nephrotic disease

Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule.

scientific article

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment

scientific article published on 27 December 2016

Targeted optical injection of gold nanoparticles into single mammalian cells

scientific article

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.

scientific article

The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.

scientific article

The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease

scientific article published on 24 February 2010

The expanding family of FERM proteins.

scientific article published on June 2013

The intracellular interactions of the L1 family of cell adhesion molecules.

scientific article published on May 2009

The novel calcium-binding protein EFHD2 is linked to frontotemporal dementia

The preparation,in vitroscreening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage

scientific article published on 15 March 2011

Towards high-throughput automated targeted femtosecond laser-based transfection of adherent cells

Transient transfection of mammalian cells using a violet diode laser

Transient transfection of mammalian cells using a violet diode laser.

scientific article

Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach to nephrotic disease

scientific article

Wavefront corrected light sheet microscopy in turbid media

article published in 2012

Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts

scientific article

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.

scientific article

Willing to Be Involved in Cancer

scientific article

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