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List of works by Michael W Epperly

A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer ⬇️

scientific article published on February 2, 2011

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis

scientific article

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage

scientific article published on 24 October 2016

A manganese-porphyrin complex decomposes H(2)O(2), inhibits apoptosis, and acts as a radiation mitigator in vivo

scientific article published on November 2011

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

journal article published in 2011

A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation

scientific article published on March 2008

A mitochondrial pathway for biosynthesis of lipid mediators

journal article published in 2014

Adipocyte differentiation in Sod2(-/-) and Sod2(+/+) murine bone marrow stromal cells is associated with low antioxidant pools

scientific journal article

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

scientific article published on 31 January 2008

Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039.

scientific article

Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).

scientific article published on 14 October 2013

Antioxidant Approaches to Management of Ionizing Irradiation Injury

scientific article

Antioxidant-Chemoprevention Diet Ameliorates Late Effects of Total-Body Irradiation and Supplements Radioprotection by MnSOD-Plasmid Liposome Administration ⬇️

scientific article published on April 5, 2011

Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase

scientific article published on March 2004

Blocking the formation of radiation-induced breast cancer stem cells

scientific article

Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damage

scientific article published in July 2006

Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium

scientific article published in September 2004

Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis

scientific article published on 20 March 2003

Bone marrow-derived stem cells and radiation response.

scientific article published on April 2009

Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors

scientific article

Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis

scientific article published in September 2007

Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines

scientific article

Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator"

scientific article published on June 2016

Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for endothelial cell adhesion molecules.

scientific article published in January 2004

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

scientific article

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death ⬇️

scientific article published on January 1, 2011

Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice

scientific article

Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells

scientific article published in January 2004

Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line.

scientific article published on November 2006

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators

scientific article (publication date: 2 January 2017)

Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy

scientific article

Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors

scientific article published on March 2007

Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines

scientific article published in July 2014

Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice

scientific article published on May 2013

Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation

scientific article published on November 2007

Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039)

scholarly article published in In Vivo

Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells

scientific article

Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures

scientific article published on 15 September 2016

FANCD2 protects against bone marrow injury from ferroptosis

scientific article published on 20 October 2016

GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines ⬇️

scientific article published on September 22, 2011

Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury

scientific article published on 01 February 2003

Graduating During a Time of War ⬇️

scientific article published on 01 April 2003

Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice

scientific article published on 8 January 2013

Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients

scientific article

Identification of Druggable Targets for Radiation Mitigation Using a Small Interfering RNA Screening Assay ⬇️

scientific article published on July 2, 2012

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways

scientific article published on 15 November 2017

Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam

scientific article

Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice.

scientific article published on March 2005

Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic and marrow stromal cells.

scientific article published in January 2007

Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice

scientific article published on July 2013

Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice

scientific article published on June 2006

Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.

scientific article

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

scientific article published on 04 October 2016

Intraesophageal Manganese Superoxide Dismutase-Plasmid Liposomes Ameliorates Novel Total-Body and Thoracic Radiation Sensitivity of NOS1−/−Mice ⬇️

scientific article published on September 1, 2010

Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice

scientific article published on 20 January 2016

Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

scientific article published in July 2004

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

scientific article

Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent ⬇️

scientific article published on May 1, 2012

Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy

scientific article

Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation

scientific article published on August 2009

Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury ⬇️

scientific article published on October 14, 2011

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma

scientific article published on 12 December 2017

Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient () Hematopoietic Progenitor Cells by a Single HPV16 Oncogene

Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane

scientific article

Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis

scientific article published in December 2002

Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas.

scientific article published in January 2003

Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation

scientific article published in January 2009

Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage

scientific article published on November 2003

Mitochondrial targeting of radioprotectants using peptidyl conjugates

scientific article published on 7 December 2006

MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus

scientific article

Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy

scientific article published on October 2008

Nanoassembly of Surfactants with Interfacial Drug-Interactive Motifs as Tailor-Designed Drug Carriers ⬇️

scientific article published on December 17, 2012

Necrostatin-1 rescues mice from lethal irradiation

scientific article

Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

scientific article published on 16 August 2013

Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice

scientific article published in November 2014

Overexpression of the transgene for manganese superoxide dismutase (MnSOD) in 32D cl 3 cells prevents apoptosis induction by TNF-alpha, IL-3 withdrawal, and ionizing radiation

scientific article published on 01 June 2003

Oxidative lipidomics of gamma-irradiation-induced intestinal injury

scientific article published on 6 September 2007

Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation

scientific article

Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin

journal article published in 2012

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

scientific article

Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death

scientific article

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

scientific article

Photodynamic therapy induced esophageal stricture--an animal model: from mouse to pig.

scientific article

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene

scientific article published in March 2003

Protection of esophageal multi-lineage progenitors of squamous epithelium (stem cells) from ionizing irradiation by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.

scientific article

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

scientific article

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells

scientific article

Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice

scientific article published on 07 January 2014

Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene

scientific article

Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene.

scientific article

Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice

scientific article published on September 2013

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition

scientific article published on 27 October 2015

Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice

scientific article

Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice

scientific article published in September 2006

Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells

scientific article published on 08 October 2008

Repopulation of the irradiation damaged lung with bone marrow-derived cells ⬇️

scientific article published on January 1, 2012

Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization

scientific article published on March 2007

Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients.

scientific article

Strategies for discovery of small molecule radiation protectors and radiation mitigators

scientific article

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

scientific article

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector

scientific article published in October 2009

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

scholarly article by Rhonda M Brand et al published 2018 in Frontiers in Pharmacology

Testicular recovery after irradiation differs in prepubertal and pubertal non-human primates, and can be enhanced by autologous germ cell transplantation

scientific article published on 25 May 2011

Thalidomide radiosensitization of normal murine hematopoietic but not squamous cell carcinoma or multiple myeloma tumor cell lines.

scientific article published on May 2006

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

scientific article published in February 2018

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

scientific article published on 22 May 2015

The Use of 3,5,4′-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death ⬇️

scientific article published on January 25, 2011

The resistance of electron-transport chain Fe-S clusters to oxidative damage during the reaction of peroxynitrite with mitochondrial complex II and rat-heart pericardium

scientific article published on 13 December 2008

The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation ⬇️

scientific article published on November 1, 2012

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

scientific article

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