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List of works by Gunnar Hedlund

A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.

scientific article published on September 1995

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells ⬇️

scientific article published on December 15, 1991

Abrogation of staphylococcal enterotoxin A-induced suppressor cell activity by the anti-Tac monoclonal antibody

scientific article published on 01 January 1987

Activation and selection of NK cells via recognition of an allogeneic, non-classical MHC class I molecule, RT1-E

scientific article published on 01 November 1999

Activation of alloreactive natural killer cells is resistant to cyclosporine

scientific article published on 01 April 1997

Activation of donor-specific CTL in a tolerant recipient of cardiac allograft

scientific article published on 01 October 1998

Allogeneic heart transplantation activates alloreactive NK cells

scientific article published on January 1997

Alloselective natural killer cells are activated by allogeneic heart transplantation and can potentially play a functional role as classic CTLs

scientific article published on 01 June 1994

Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.

scientific article

Bacterial superantigens as anti-tumour agents: induction of tumour cytotoxicity in human lymphocytes by staphylococcal enterotoxin A.

scientific article published in January 1991

Catalase and lipopolysaccharide enhance proliferation in the rat mixed lymphocyte reaction

scientific article published on 01 September 1987

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

scientific article published on October 1993

Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity

scientific article published on 01 April 1994

Comparison of immune responses induced by rat RT-1 antigens presented as inserts into liposomes, as protein micelles and as intact cells.

scientific article

Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding

scientific article published on March 1997

Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors

scientific article published on 01 August 1995

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

scientific article published on September 1994

Different types of in vivo induced cytolytic T lymphocytes are all LFA-Ihigh and lack CD45 exon 4 (CD45RA) but show distinct CD45RC profiles

scientific article published on 01 September 1994

Distinct splicing of CD45 mRNA in activated rat gamma delta cytotoxic T lymphocytes

scientific article published on 01 January 1995

Enhanced and prolonged efficacy of superantigen-induced cytotoxic T lymphocyte activity by interleukin-2 in vivo ⬇️

scientific article published on 01 August 1995

Evidence for the existence of W3/13+ monocytes in the rat

scientific article published on 01 October 1986

Expression of CD11a and CD45R isoforms defines distinct subsets of CD8+ TCR alpha beta and TCR gamma delta CTL in vivo

scientific article published on August 1995

Functions of rat CD4+ T cell subsets defined by CD45RB: CD45RB− cells have a much stronger response to recall antigens, whereas polyclonally activated cells of both subsets are equally efficient producers of IFN in the presence of exogenous IL-2 ⬇️

scientific article published on February 1, 1991

Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release

scientific article published on May 1996

Gamma interferon induces the appearance of a CD4-, major histocompatibility complex class II+ macrophage subpopulation in the rat peritoneal cavity

scientific article published on 01 June 1989

Human major histocompatibility complex class II-negative colon carcinoma cells present staphylococcal superantigens to cytotoxic T lymphocytes: evidence for a novel enterotoxin receptor

scientific article published on May 1991

Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules

scientific article published in December 1993

ICAM‐1 costimulation induces IL‐2 but inhibits IL‐10 production in superantigen‐activated human CD4+ T cells ⬇️

scientific article published on August 1, 1998

Immunological abnormalities in a child with constitutional aplastic anemia

scientific article published on 01 January 1986

Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice ⬇️

scientific article published on 01 August 1993

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors

scientific article published on February 1996

In vivo induced allo-reactive natural killer cells ⬇️

scientific article published on 01 September 1992

In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity

scientific article published on November 1991

Increased proportion of CD4+CDw29+CD45R-UCHL-1+ lymphocytes in the cerebrospinal fluid of both multiple sclerosis patients and healthy individuals

scientific article published in February 1989

Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells

scientific article published on 01 December 1990

Induction of interleukin-1 in human monocytes by the superantigen staphylococcal enterotoxin A requires the participation of T cells

scientific article published in October 1991

Induction of transplantation immunity to rat colon carcinoma isografts by implantation of intact fetal colon tissue

scientific article published on 01 July 1980

Inhibitory effects of histamine on interleukin 2 and gamma interferon production of different human T helper cell subsets

scientific article published on 01 December 1988

Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody ⬇️

scientific article published on November 15, 1993

Linomide, a novel immunomodulator that prevents death in four models of septic shock

scientific article published on 01 September 1993

Locally superantigen-activated peritoneal cytolytic T lymphocytes belong to the CD8+ CD45RC- subset and lyse MHC class II+ tumor cells

scientific article published on 01 December 1992

Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia

scientific article published on 01 January 1988

Magnetic carbohydrate nanoparticles for affinity cell separation

scientific article published on 01 October 1986

Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes

scientific article published in January 1989

Monoclonal antibodies and superantigens: a novel therapeutic approach

scientific article

Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy

scientific article published on September 1994

Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents

scientific article published on October 1991

Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling

scientific article published on 01 August 1993

Overexpression of p65 and c-Jun substitutes for B7-1 costimulation by targeting the CD28RE within the IL-2 promoter ⬇️

scientific article published on June 1, 1998

Phenotypical and functional differentiation of CD4+ CD45RA+ human T cells following polyclonal activation

scientific article published on 01 September 1990

Preparation and characterization of conjugates of monoclonal antibodies and staphylococcal enterotoxin A using a new hydrophilic cross-linker

scientific article published on 01 November 1993

Prevention of superantigen-induced down-regulation of T-cell mediated cytotoxic activity by IL-2 in vivo

scientific article published on 01 February 1997

Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment

scientific article published on 01 April 1997

Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells

scientific article published on 01 June 1990

Proliferation and differentiation of alloselective NK cells after alloimmunization-evidence for an adaptive NK response

scientific article published on 01 October 1999

Proliferation of human CD4+45R+ and CD4+45R- T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4+45R- T cells

scientific article published on 01 January 1989

Rapid response to Con A by CD4+CD45R- rat memory lymphocytes as compared to CD4+CD45R+ lymphocytes

scientific article published in April 1989

Role of the adhesion molecule ICAM-1 (CD54) in staphylococcal enterotoxin-mediated cytotoxicity

scientific article published on January 1991

Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma

scientific article

Selective induction of OX19+ (CD5+) or OX19- (CD5-) alloreactive cytolytic lymphocytes in the rat

scientific article published on 01 April 1987

Self-MHC class Ia (RT1-A(n)) protects cells co-expressing the activatory allogeneic MHC class Ib molecule (RT1-E(u)) from NK lysis

scientific journal article

Staphylococcal enterotoxin-dependent cell-mediated cytotoxicity

scientific article published on January 1991

Staphylococcal enterotoxins direct and trigger CTL killing of autologous HLA-DR+ mononuclear leukocytes and freshly prepared leukemia cells

scientific article published on 01 September 1990

Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity

scientific article published on May 1991

Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway ⬇️

scientific article published on April 1, 1992

Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells

scientific article published on 01 January 1993

Superantigen-induced anergy in cytotoxic CD8+ T cells

scientific article published on 01 June 1995

Superantigen-induced cytokines suppress growth of human colon-carcinoma cells

scientific article published on 01 May 1993

Superantigens anergize cytokine production but not cytotoxicity in vivo

scientific article published on 01 May 1994

Synergistic action of gamma interferon and catalase to reverse the suppressive effect of peritoneal macrophages on concanavalin A-induced lymphocyte proliferation

scientific article published on 01 July 1986

T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.

scientific article published on January 1995

T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens

scientific article published on 01 January 1993

TCR alpha beta+ anti-tumor cytolytic T lymphocytes express NKR-P1 whilethe anti-tumor activity of TCR gamma delta+ T lymphocytes is not correlated to NKR-P1 expression

scientific article published on 01 November 1996

Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins

scientific article published on September 1990

Targeting of superantigens

scientific article published on January 1993

The LFA-3 adhesion pathway is differently utilized by superantigen-activated human CD4+ T-cell subsets

scientific article published in August 1992

The effects of leflunomide and cyclosporin A on rejection of cardiac allografts in the rat

scientific article published on 01 March 1998

The membrane phenotype of in vivo induced tumor selective cytolytic lymphocytes of the rat: a distinction from NK cells

scientific article

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells

scientific article published on 01 January 1997

The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells

scientific article published on February 1997

Tumor-selective cytolysis is executed exclusively by CD45R+ CTL whereas allo-specific cytotoxicity can be executed also by CD45R- CTL.

scientific article published on March 1990

Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies

scientific article published on 01 August 1988

Use of a monoclonal rat anti-mouse Ig light chain (RAMOL-1) antibody reduces background binding in immunohistochemical and fluorescent antibody analysis

scientific article published in July 1989

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