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List of works by Mikael Dohlsten

A mutation of F47 to A in staphylococcus enterotoxin A activates the T-cell receptor Vbeta repertoire in vivo ⬇️

scientific article published on December 1, 1997

A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.

scientific article published on September 1995

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells ⬇️

scientific article published on December 15, 1991

A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies

scientific article published on March 1997

Activation of alloreactive natural killer cells is resistant to cyclosporine

scientific article published on 01 April 1997

Allogeneic heart transplantation activates alloreactive NK cells

scientific article published on January 1997

Alloselective natural killer cells are activated by allogeneic heart transplantation and can potentially play a functional role as classic CTLs

scientific article published on 01 June 1994

Antagonistic effects of the staphylococcal enterotoxin a mutant, SEA(F47A/D227A), on psoriasis in the SCID-hu xenogeneic transplantation model

scientific article published on 01 April 2001

Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells

scientific article published on 01 September 1995

Antibody-targeted superantigen therapy induces tumor-infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma

scientific article published on 01 January 1996

Antibody-targeted superantigens are potent inducers of tumor-infiltrating T lymphocytes in vivo

scientific article

Antibody-targeted superantigens in cancer immunotherapy ⬇️

scientific article published on September 1, 1996

Antibody‐directed superantigen‐mediated T‐cell killing of myeloid leukaemic cell line cells ⬇️

scientific article published on April 1, 1998

Bacterial superantigens as anti-tumour agents: induction of tumour cytotoxicity in human lymphocytes by staphylococcal enterotoxin A.

scientific article published in January 1991

Biased dependency of CD80 versus CD86 in the induction of transcription factors regulating the human IL-2 promoter ⬇️

scientific article published on April 1, 1998

Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines

scientific article published on 01 May 1989

Catalase and lipopolysaccharide enhance proliferation in the rat mixed lymphocyte reaction

scientific article published on 01 September 1987

Characterization of individual tumor necrosis factor alpha-and beta-producing cells after polyclonal T cell activation

scientific article published in October 1989

Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.

scientific article

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

scientific article published on October 1993

Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity

scientific article published on 01 April 1994

Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding

scientific article published on March 1997

Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors

scientific article published on 01 August 1995

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

scientific article published on September 1994

Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression ⬇️

scientific article published on November 1, 1995

Crystal structure of the superantigen staphylococcal enterotoxin type A

scientific article

Different types of in vivo induced cytolytic T lymphocytes are all LFA-Ihigh and lack CD45 exon 4 (CD45RA) but show distinct CD45RC profiles

scientific article published on 01 September 1994

Distinct splicing of CD45 mRNA in activated rat gamma delta cytotoxic T lymphocytes

scientific article published on 01 January 1995

Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells

scientific article published on August 1993

Enhanced and prolonged efficacy of superantigen-induced cytotoxic T lymphocyte activity by interleukin-2 in vivo ⬇️

scientific article published on 01 August 1995

Expression of CD11a and CD45R isoforms defines distinct subsets of CD8+ TCR alpha beta and TCR gamma delta CTL in vivo

scientific article published on August 1995

Functional characterization of the interaction between the superantigen staphylococcal enterotoxin A and the TCR

scientific article published on 01 May 1997

Functions of rat CD4+ T cell subsets defined by CD45RB: CD45RB− cells have a much stronger response to recall antigens, whereas polyclonally activated cells of both subsets are equally efficient producers of IFN in the presence of exogenous IL-2 ⬇️

scientific article published on February 1, 1991

Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release

scientific article published on May 1996

Gamma interferon induces the appearance of a CD4-, major histocompatibility complex class II+ macrophage subpopulation in the rat peritoneal cavity

scientific article published on 01 June 1989

Gene transfer of a hybrid interleukin-1β gene to B16 mouse melanoma recruits leucocyte subsets and reduces tumour growth in vivo ⬇️

scientific article published on July 1, 1997

Genetically engineered superantigens as tolerable antitumor agents

scientific article

Genetically engineered superantigens in experimental tumor therapy

scientific article published on January 1996

Histamine acts directly on human T cells to inhibit interleukin-2 and interferon-gamma production

scientific article published on 01 October 1987

Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis

scientific article published on 01 September 1986

Histamine inhibits interleukin 1 production by lipopolysaccharide-stimulated human peripheral blood monocytes

scientific article published on 01 May 1988

Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells

scientific article published in November 1985

Human major histocompatibility complex class II-negative colon carcinoma cells present staphylococcal superantigens to cytotoxic T lymphocytes: evidence for a novel enterotoxin receptor

scientific article published on May 1991

Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules

scientific article published in December 1993

ICAM‐1 costimulation induces IL‐2 but inhibits IL‐10 production in superantigen‐activated human CD4+ T cells ⬇️

scientific article published on August 1, 1998

IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common gamma-chain of the IL-2 receptor

scientific article published on 01 February 2000

Immune response during tumor therapy with antibody-superantigen fusion proteins

scientific article published on 01 September 1996

Immunological abnormalities in a child with constitutional aplastic anemia

scientific article published on 01 January 1986

Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic mice ⬇️

scientific article published on 01 August 1993

Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo

scientific article published on 01 January 1997

Immunotherapy of human colon cancer by antibody-targeted superantigens

scientific article published on 01 September 1995

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors

scientific article published on February 1996

In vivo induced allo-reactive natural killer cells ⬇️

scientific article published on 01 September 1992

In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity

scientific article published on November 1991

Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells

scientific article published on 01 December 1990

Induction of interleukin-1 in human monocytes by the superantigen staphylococcal enterotoxin A requires the participation of T cells

scientific article published in October 1991

Inhibitory effects of histamine on interleukin 2 and gamma interferon production of different human T helper cell subsets

scientific article published on 01 December 1988

Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody ⬇️

scientific article published on November 15, 1993

Locally superantigen-activated peritoneal cytolytic T lymphocytes belong to the CD8+ CD45RC- subset and lyse MHC class II+ tumor cells

scientific article published on 01 December 1992

Long-term survival and complete cures of B16 melanoma-carrying animals after therapy with tumor-targeted IL-2 and SEA

scientific article published on 01 March 1999

Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia

scientific article published on 01 January 1988

Man-made superantigens: Tumor-selective agents for T-cell-based therapy

scientific article published on 01 April 1998

Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4+ CDw29- CD45R- p80- human T lymphocytes

scientific article published in January 1989

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.

scientific article published on April 1997

Monoclonal antibodies and superantigens: a novel therapeutic approach

scientific article

Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy

scientific article published on September 1994

Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents

scientific article published on October 1991

Mutations in the MHC class II binding domains of staphylococcal enterotoxin A differentially affect T cell receptor Vbeta specificity

scientific article published on 01 November 1996

Overexpression of p65 and c-Jun substitutes for B7-1 costimulation by targeting the CD28RE within the IL-2 promoter ⬇️

scientific article published on June 1, 1998

Perforin and IFN-gamma are involved in the antitumor effects of antibody-targeted superantigens.

scientific article published in June 1998

Phenotypical and functional differentiation of CD4+ CD45RA+ human T cells following polyclonal activation

scientific article published on 01 September 1990

Preface

scientific article published on 01 April 1998

Preparation and characterization of conjugates of monoclonal antibodies and staphylococcal enterotoxin A using a new hydrophilic cross-linker

scientific article published on 01 November 1993

Prevention of superantigen-induced down-regulation of T-cell mediated cytotoxic activity by IL-2 in vivo

scientific article published on 01 February 1997

Prevention of superantigen-induced tolerance in vivo by interleukin-2 treatment

scientific article published on 01 April 1997

Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells

scientific article published on 01 June 1990

Proliferation of human CD4+45R+ and CD4+45R- T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4+45R- T cells

scientific article published on 01 January 1989

Rapid response to Con A by CD4+CD45R- rat memory lymphocytes as compared to CD4+CD45R+ lymphocytes

scientific article published in April 1989

Rapid tyrosine phosphorylation of Lck following ligation of the tumor-associated cell surface molecule A6H.

scientific article published on March 1999

Regulation of superantigen-induced T cell activation in the absence and the presence of MHC class II

scientific article published on 01 October 1996

Repeated treatment with antibody-targeted superantigens strongly inhibits tumor growth ⬇️

scientific article published on April 13, 1998

Role of the adhesion molecule ICAM-1 (CD54) in staphylococcal enterotoxin-mediated cytotoxicity

scientific article published on January 1991

Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells

scientific article

Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors ⬇️

scientific article published on January 1, 1998

Staphylococcal enterotoxin H displays unique MHC class II-binding properties.

scientific article

Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines

scientific article published on December 1998

Staphylococcal enterotoxin-dependent cell-mediated cytotoxicity

scientific article published on January 1991

Staphylococcal enterotoxins A, D, and E. Structure and function, including mechanism of T-cell superantigenicity

scientific article published on May 1997

Staphylococcal enterotoxins direct and trigger CTL killing of autologous HLA-DR+ mononuclear leukocytes and freshly prepared leukemia cells

scientific article published on 01 September 1990

Staphylococcal protein A (SpA) does not induce production of interferon-gamma in human mononuclear blood cells

scientific article published on 01 June 1984

Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity

scientific article published on May 1991

Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway ⬇️

scientific article published on April 1, 1992

Superantigen activation of CD4+ and CD8+T cells from HIV-infected subjects: role of costimulatory molecules and antigen-presenting cells (APC)

scientific article published on January 1998

Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer

scientific article published on May 1997

Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells

scientific article published on 01 January 1993

Superantigen-induced anergy in cytotoxic CD8+ T cells

scientific article published on 01 June 1995

Superantigen-induced cytokines suppress growth of human colon-carcinoma cells

scientific article published on 01 May 1993

Superantigen-induced lysis of melanoma cells

scientific article published on 01 June 1997

Superantigen-staphylococal-enterotoxin-A-dependent and antibody-targeted lysis of GD2-positive neuroblastoma cells ⬇️

scientific article published on 01 August 1995

Superantigens anergize cytokine production but not cytotoxicity in vivo

scientific article published on 01 May 1994

Synergistic action of gamma interferon and catalase to reverse the suppressive effect of peritoneal macrophages on concanavalin A-induced lymphocyte proliferation

scientific article published on 01 July 1986

T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.

scientific article published on January 1995

T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens

scientific article published on 01 January 1993

T-cell cytotoxicity assays for studying the functional interaction between the superantigen staphylococcal enterotoxin A and T-cell receptors

scientific article published on 01 January 2000

T-cell stimulation and cytokine release induced by staphylococcal enterotoxin A (SEA) and the SEAD227A mutant

scientific article published on 01 January 1997

TCR alpha beta+ anti-tumor cytolytic T lymphocytes express NKR-P1 whilethe anti-tumor activity of TCR gamma delta+ T lymphocytes is not correlated to NKR-P1 expression

scientific article published on 01 November 1996

Targeted Superantigens for Immunotherapy of Haematopoietic Tumours ⬇️

scientific article published on January 1, 1998

Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins

scientific article published on September 1990

Targeting of superantigens

scientific article published on January 1993

The Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7 A resolution. Implications for major histocompatibility complex class II binding

scientific article

The LFA-3 adhesion pathway is differently utilized by superantigen-activated human CD4+ T-cell subsets

scientific article published in August 1992

The TcR-CD3 complex is required for activation of human lymphocytes with staphylococcal enterotoxin A

scientific article published on 01 February 1990

The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization.

scientific article

The distinct role of CD4+ and CD8+ T-cells during the anti-tumour effects of targeted superantigens

scientific article published on September 1999

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells

scientific article published on 01 January 1997

The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells

scientific article published on February 1997

Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen

scientific article published on July 2001

Treatment with tumor-reactive Fab-IL-2 and Fab-staphylococcal enterotoxin A fusion proteins leads to sustained T cell activation, and long-term survival of mice with established tumors

scientific article published on 01 November 1999

Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses

scientific article published on May 1997

Tumor-selective cytolysis is executed exclusively by CD45R+ CTL whereas allo-specific cytotoxicity can be executed also by CD45R- CTL.

scientific article published on March 1990

Tumor‐reactive superantigens suppress tumor growth in humanized scid mice ⬇️

scientific article published on August 9, 1995

Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies

scientific article published on 01 August 1988

Vaccination with B16 melanoma cells expressing a secreted form of interleukin-1beta induces tumor growth inhibition and an enhanced immunity against the wild-type B16 tumor.

scientific article published in October 2000

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