List of works - Johan Bylund

A bactericidal cecropin-A peptide with a stabilized alpha-helical structure possess an increased killing capacity but no proinflammatory activity

scientific article published in December 2004

A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger neutrophils

scientific article

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

scientific article published in February 2014

A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.

scientific article

A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism

scientific article

A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis

scientific article

A simple skin blister technique for the study of in vivo transmigration of human leukocytes

scientific article published on 06 April 2013

Analyzing cell death events in cultured leukocytes.

scientific article published in January 2012

Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling

scientific article published on 3 March 2014

CFP-10 from Mycobacterium tuberculosis selectively activates human neutrophils through a pertussis toxin-sensitive chemotactic receptor

scientific article published on 20 October 2014

Challenging the opinion that SAPHO syndrome is associated with low intracellular ROS production in neutrophils

scientific article published on 28 September 2015

Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific events

scientific article published on 10 December 2007

Chronic granulomatous disease: from genetic defect to clinical presentation

scientific article published in January 2005

Collection of in vivo transmigrated neutrophils from human skin

scientific article published on January 2014

Cord-forming mycobacteria induce DNA meshwork formation by human peripheral blood mononuclear cells

scientific article published on 15 November 2012

Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor

scientific article published on 9 August 2007

Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

scientific article

DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils

scientific article published on 18 October 2019

Divergent effects on phagocytosis by macrophage-derived oxygen radicals

scientific article published on 14 August 2009

Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

scientific article published on 21 December 2017

Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different Receptors

scientific article

Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species

scientific article

Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question

scientific article published on 21 September 2017

Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma

Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils

scientific article

Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function

scientific article published on 10 January 2018

Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.

scientific article

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells

scientific article

Immunostimulatory DNA induces degranulation and NADPH-oxidase activation in human neutrophils while concomitantly inhibiting chemotaxis and phagocytosis

scientific article published in October 2002

Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome

scientific article published on November 2013

Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils.

scientific article published on 27 December 2012

Interleukin-8-derived peptide has antibacterial activity

scientific article published on September 2005

Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality

scientific article published on 01 June 2019

Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for?

scientific article published on 24 September 2010

Ligand recognition and activation of formyl peptide receptors in neutrophils

scientific article

Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1.

scientific article

MPO deficiency confers impaired processing of neutrophil reactive oxygen species in a patient with severe CRMO.

scientific article

Measurement of respiratory burst products generated by professional phagocytes

scientific article published in January 2007

Measurement of respiratory burst products, released or retained, during activation of professional phagocytes

scientific article published in January 2014

Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis

scientific article

NADPH-oxidase activation in murine neutrophils via formyl peptide receptors

scientific article published in January 2003

Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species

scientific article

Neutrophils from patients with SAPHO syndrome show no signs of aberrant NADPH oxidase-dependent production of intracellular reactive oxygen species

scientific article published on 27 April 2016

Olfactomedin-4 autoantibodies give unusual c-ANCA staining patterns with reactivity to a subpopulation of neutrophils

scientific article published on 11 November 2014

Outer membrane protein A deficient Escherichia coli activates neutrophils to produce superoxide and shows increased susceptibility to antibacterial peptides

scientific article published in July 2003

P02-025 - Homozygous Q705K sequence variant in NLRP3.

scientific article

P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism

scientific article published on 17 July 2015

PW03-003 – Altered neutrophil function in PFAPA.

scientific article

Phagocyte interactions with Mycobacterium tuberculosis--Simultaneous analysis of phagocytosis, phagosome maturation and intracellular replication by imaging flow cytometry

scientific article published on 14 October 2015

Phenol-Soluble Modulin α Peptide Toxins from Aggressive Staphylococcus aureus Induce Rapid Formation of Neutrophil Extracellular Traps through a Reactive Oxygen Species-Independent Pathway

scientific article published on 9 March 2017

Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice

scientific article

Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori

scientific article

Quantification of heterotypic granule fusion in human neutrophils by imaging flow cytometry

scientific article

Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production

scientific article

Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium

scientific article published on 28 May 2003

Receptor-Dependent and -Independent Immunomodulatory Effects of Phenol-Soluble Modulin Peptides from Staphylococcus aureus on Human Neutrophils Are Abrogated through Peptide Inactivation by Reactive Oxygen Species ⬇️

scientific article published on March 19, 2012

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

scientific article published on 01 October 2019

Regulation of neutrophil apoptosis differs after in vivo transmigration to skin chambers and synovial fluid: a role for inflammasome-dependent interleukin-1β release.

scientific article published on 5 April 2013

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

scientific article published in October 2009

Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1.

scientific article published on 25 October 2007

Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.

scientific article published on 5 November 2007

Severe chronic non-bacterial osteomyelitis associated with MPO deficiency

scientific article

Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation

scientific article published on July 2015

Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy

scientific article published on August 2003

The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels

scientific article published on 17 March 2009

The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

scientific article published on 8 August 2016

The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the a

scientific article published on 25 August 2008

The host defense peptide LL-37 selectively permeabilizes apoptotic leukocytes

scientific article published on 15 December 2008

The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro

scientific article

The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop

scientific article published on 2 April 2013

The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8.

scientific article

The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1.

scientific article published on 7 July 2007

List of works by Johan Bylund

A bactericidal cecropin-A peptide with a stabilized alpha-helical structure possess an increased killing capacity but no proinflammatory activity

A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger neutrophils

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.

A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism

A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis

A simple skin blister technique for the study of in vivo transmigration of human leukocytes

Analyzing cell death events in cultured leukocytes.

Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling

CFP-10 from Mycobacterium tuberculosis selectively activates human neutrophils through a pertussis toxin-sensitive chemotactic receptor

Challenging the opinion that SAPHO syndrome is associated with low intracellular ROS production in neutrophils

Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific events

Chronic granulomatous disease: from genetic defect to clinical presentation

Collection of in vivo transmigrated neutrophils from human skin

Cord-forming mycobacteria induce DNA meshwork formation by human peripheral blood mononuclear cells

Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor

Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils

Divergent effects on phagocytosis by macrophage-derived oxygen radicals

Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different Receptors

Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species

Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question

Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma

Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils

Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function

Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells

Immunostimulatory DNA induces degranulation and NADPH-oxidase activation in human neutrophils while concomitantly inhibiting chemotaxis and phagocytosis

Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome

Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils.

Interleukin-8-derived peptide has antibacterial activity

Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality

Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for?

Ligand recognition and activation of formyl peptide receptors in neutrophils

Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1.

MPO deficiency confers impaired processing of neutrophil reactive oxygen species in a patient with severe CRMO.

Measurement of respiratory burst products generated by professional phagocytes

Measurement of respiratory burst products, released or retained, during activation of professional phagocytes

Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis

NADPH-oxidase activation in murine neutrophils via formyl peptide receptors

Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species

Neutrophils from patients with SAPHO syndrome show no signs of aberrant NADPH oxidase-dependent production of intracellular reactive oxygen species

Olfactomedin-4 autoantibodies give unusual c-ANCA staining patterns with reactivity to a subpopulation of neutrophils

Outer membrane protein A deficient Escherichia coli activates neutrophils to produce superoxide and shows increased susceptibility to antibacterial peptides

P02-025 - Homozygous Q705K sequence variant in NLRP3.

P2Y2 receptor signaling in neutrophils is regulated from inside by a novel cytoskeleton-dependent mechanism

PW03-003 – Altered neutrophil function in PFAPA.

Phagocyte interactions with Mycobacterium tuberculosis--Simultaneous analysis of phagocytosis, phagosome maturation and intracellular replication by imaging flow cytometry

Phenol-Soluble Modulin α Peptide Toxins from Aggressive Staphylococcus aureus Induce Rapid Formation of Neutrophil Extracellular Traps through a Reactive Oxygen Species-Independent Pathway

Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice

Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori

Quantification of heterotypic granule fusion in human neutrophils by imaging flow cytometry

Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production

Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium

Receptor-Dependent and -Independent Immunomodulatory Effects of Phenol-Soluble Modulin Peptides from Staphylococcus aureus on Human Neutrophils Are Abrogated through Peptide Inactivation by Reactive Oxygen Species ⬇️

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome

Regulation of neutrophil apoptosis differs after in vivo transmigration to skin chambers and synovial fluid: a role for inflammasome-dependent interleukin-1β release.

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1.

Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.

Severe chronic non-bacterial osteomyelitis associated with MPO deficiency

Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation

Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy

The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels

The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the a

The host defense peptide LL-37 selectively permeabilizes apoptotic leukocytes

The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro

The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop

The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8.

The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1.