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List of works by Annemieke Geluk

A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct

scientific article published on August 1999

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice

scientific article published on 24 October 2012

A novel, highly efficient peptide-HLA class I binding assay using unfolded heavy chain molecules: identification of HIV-1 derived peptides that bind to HLA-A*0201 and HLA-A*0301 ⬇️

scientific article published on July 14, 1997

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

scientific article published on 8 February 2018

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

scientific article published on 13 August 2012

An HLA class II restricted T-cell is able to recognize about a million different peptides

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection

scientific article published on 14 January 2013

Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.

scientific article

Application of new host biomarker profiles in quantitative point-of-care tests facilitates leprosy diagnosis in the field

scientific article published on 14 August 2019

Archival, paleopathological and aDNA-based techniques in leprosy research and the case of Father Petrus Donders at the Leprosarium 'Batavia', Suriname

scientific article published on 17 August 2019

BCG and Adverse Events in the Context of Leprosy.

scientific article published on 4 April 2018

Biomarkers for leprosy: would you prefer T (cells)?

scientific article published on March 1, 2013

Blood RNA signature RISK4LEP predicts leprosy years before clinical onset

scientific article published on 03 June 2021

CRP: tell-tale biomarker or common denominator?

scientific article

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

scientific article published on 11 February 2020

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy

scientific article published on 22 September 2016

Challenges in immunodiagnostic tests for leprosy

scientific article published on 28 March 2013

Clinical manifestations of leprosy after BCG vaccination: an observational study in Bangladesh

scientific article published on 18 February 2015

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method

scientific article

Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis

scientific article published on 23 October 2018

Complement component C1q as serum biomarker to detect active tuberculosis

scientific article published in 2018

Correlates of immune exacerbations in leprosy

scientific article published on 24 June 2018

Cytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naive armadillos.

scientific article

Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack

Detection of humoral immunity to mycobacteria causing leprosy in Eurasian red squirrels (Sciurus vulgaris) using a quantitative rapid test

Development of a mouse food pad model for detection of sub clinical leprosy

scientific article published on 01 December 2011

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

scientific article published on 4 May 2016

Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression

scientific article published on 8 June 2017

Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy.

scientific article

Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells

scientific article published on 16 August 2005

Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

scientific article published on 30 August 2011

Editor's choice December 2011

scientific article published on 01 December 2011

Effectiveness of single-dose rifampicin after BCG vaccination to prevent leprosy in close contacts of patients with newly diagnosed leprosy: A cluster randomized controlled trial

scientific article published on 06 September 2019

Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays

scientific article published on 28 April 2010

Evaluation of Immunodiagnostic Tests for Leprosy in Brazil, China and Ethiopia

scientific article published in Scientific Reports

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

scientific article published on 13 June 2016

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

scientific article published on 28 June 2018

Exploratory urinary metabolomics of type 1 leprosy reactions

scientific article

Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients

scientific article published on 13 March 2020

Field-Friendly Test for Monitoring Multiple Immune Response Markers during Onset and Treatment of Exacerbated Immunity in Leprosy.

scientific article published on 30 March 2016

Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. ⬇️

scientific article

Field-friendly serological tests for determination of M. leprae-specific antibodies.

scientific article published on 21 August 2017

Fingerstick test quantifying humoral and cellular biomarkers indicative for M. leprae infection

scientific article published on 26 January 2019

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects

scientific article

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis

scientific article published on 28 January 2009

Functional characterization of ocular-derived human alphaherpesvirus cross-reactive CD4 T cells.

scientific article published on 12 March 2014

Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

scientific article published on 09 November 2020

Genomic Characterization of Mycobacterium leprae to Explore Transmission Patterns Identifies New Subtype in Bangladesh

scientific article published on 16 June 2020

HLA and leprosy in the pre and postgenomic eras

scientific article

HLA-DR binding analysis of peptides from islet antigens in IDDM ⬇️

scientific article published on 01 October 1998

HLA-DR/DQ Transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential ⬇️

scientific article published on 01 January 1998

Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19

scientific article published in 2023

Household Contacts of Leprosy Patients in Endemic Areas Display a Specific Innate Immunity Profile

scientific article published on 11 August 2020

Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis

scientific article published on May 2002

Identification of HLA class II-restricted determinants ofMycobacteriumtuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice ⬇️

scientific article published on September 1, 1998

Identification of Specific Proteins and Peptides in Mycobacterium leprae Suitable for the Selective Diagnosis of Leprosy

scientific article published on 01 December 2005

Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

scholarly article

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction

scientific article published on 10 October 2019

Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals

scientific article

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy

scientific article published in 2012

Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa

scientific article published in December 2011

Infliximab partially impairs the anti‐Mycobacterium tuberculosis immune responses of severe psoriasis patients with positive tuberculin skin‐test ⬇️

scientific article published on May 30, 2011

Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

scientific article

Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia

scientific article

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

scientific article published on November 2007

Lack of evidence for the presence of leprosy bacilli in red squirrels from North-West Europe

scientific article published on 02 December 2019

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

scientific article published on 14 May 2007

Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.

scientific article

Leprosy Diagnostic Test Development As a Prerequisite Towards Elimination: Requirements from the User's Perspective

scientific article published on 11 February 2016

Longitudinal IP-10 Serum Levels Are Associated with the Course of Disease Activity and Remission in Patients with Rheumatoid Arthritis

scientific article published on 07 June 2017

Longitudinal assessment of anti-PGL-I serology in contacts of leprosy patients in Bangladesh.

scientific article

Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal

scientific article published on 28 October 2015

Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions

scientific article published on 27 December 2013

ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria

scientific article published on 24 June 2011

Minimally invasive sampling to identify leprosy patients with a high bacterial burden in the Union of the Comoros

scientific article

Minimum requirements and optimal testing strategies of a diagnostic test for leprosy as a tool towards zero transmission: A modeling study.

scientific article published on 25 May 2018

Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD 65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule ⬇️

scientific article published on January 1, 1998

Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa

scientific article

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal

scientific article published on December 2012

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

scientific article

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

scientific article

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

scientific article

Opening a Can of Worms: Leprosy Reactions and Complicit Soil-Transmitted Helminths

scientific article published on September 2017

Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy

scientific article

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls

scientific article published on 29 January 2012

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

scientific article published on 11 May 2020

Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease

scientific article published on December 2011

Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection

scientific article

Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis

scientific article

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

scholarly article by Hoebert S. Hiemstra et al published August 1999 in European Journal of Immunology

Quantitative lateral flow strip assays as User-Friendly Tools To Detect Biomarker Profiles For Leprosy

scientific article published on 29 September 2016

Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection

scientific article published on 16 January 2008

Reply to: Single-dose rifampicin and BCG to prevent leprosy

scientific article published on 31 January 2020

Report on the sixth meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held in Beijing, China on 23-25 August 2010

article

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis

scientific article published on 22 July 2015

Synthetic Phenolic Glycolipids for application in diagnostic tests  for leprosy

scientific article published on 17 December 2020

T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination

scientific article published on 26 March 2007

T-cell regulation in lepromatous leprosy

scientific article

T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients

scientific article

The combined effect of chemoprophylaxis with single dose rifampicin and immunoprophylaxis with BCG to prevent leprosy in contacts of newly diagnosed leprosy cases: a cluster randomized controlled trial (MALTALEP study).

scientific article

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

scientific article published on 14 May 2014

Use of lateral flow assays to determine IP-10 and CCL4 levels in pleural effusions and whole blood for TB diagnosis

scientific article

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application

scientific article published on 26 February 2018

Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease

scientific article published on 26 February 2021

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

scientific article published on 29 November 2019

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