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List of works by Erik Portelius

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

scientific article published on 14 January 2008

A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease

scientific article

A novel pathway for amyloid precursor protein processing

scientific article

A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls

scientific article published in January 2013

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

scientific article published on 7 March 2016

APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment

scientific article

APP metabolism regulates tau proteostasis in human cerebral cortex neurons

scientific article published on 23 April 2015

Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure

scientific article

Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs

scientific article published on January 2010

Alzheimer's disease markers in the aged sheep (Ovis aries).

scientific article

Alzheimer's disease--Recent biomarker developments in relation to updated diagnostic criteria

scientific article

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

scholarly article by Bruno Becker published in August 2018

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

scientific article published on 20 November 2017

Amyloid-β metabolism in Niemann-Pick C disease models and patients

scientific article

Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease

scientific article published on January 2012

An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid

scientific article

Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay

scientific article published on 14 August 2013

Aspects of beta-amyloid as a biomarker for Alzheimer's disease

scientific article published on June 2007

Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms

scientific article published on 14 January 2014

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

scientific article published on 2 November 2015

Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

scientific article published on 01 March 2019

Astroglial activation and altered amyloid metabolism in human repetitive concussion

scientific article published on 10 March 2017

Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases

scientific article

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system

scientific article

Biomarkers, assays, and therapies for Alzheimer disease

scientific article

Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer's disease by hybrid immunoprecipitation mass spectrometry

scientific article published on 13 January 2015

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

scientific article published on 16 June 2015

CSF Aβ1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardisation

scientific article

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

scientific article published on 8 April 2016

CSF neurofilament light concentration is increased in presymptomatic CHMP2B mutation carriers

scientific article published on 13 December 2017

Case Report of Complex Amyotrophic Lateral Sclerosis with Cognitive Impairment and Cortical Amyloid Deposition

scientific article published in August 2015

Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease

scientific article published on 20 September 2016

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

scientific article published in December 2014

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology

scientific article published on 26 April 2018

Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease

scientific article

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

scientific article published on 17 August 2016

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele

scientific article

Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry

scientific article

Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease

scientific article

Characterization of tau in cerebrospinal fluid using mass spectrometry

scientific article published on 20 March 2008

Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice

scientific article published on 23 February 2011

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls

scientific article published on July 2015

Clinical proteomics in neurodegenerative disorders

scientific article published on 13 February 2008

Confounding factors influencing amyloid Beta concentration in cerebrospinal fluid

scientific article

Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry

scientific article published in April 2006

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

scientific article

Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease

scientific article published on 17 April 2017

Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease

scientific article

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology

scientific article published on 12 October 2018

Evaluation of sample fractionation using micro-scale liquid-phase isoelectric focusing on mass spectrometric identification and quantitation of proteins in a SILAC experiment

scientific article published on January 2007

Evaluation of the Performance of Novel Aβ Isoforms as Theragnostic Markers in Alzheimer’s Disease: From the Cell to the Patient ⬇️

scientific article published on January 1, 2012

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

scientific article published on 20 February 2017

Expanding the cerebrospinal fluid endopeptidome

scientific article published on 03 January 2017

Explorative and targeted neuroproteomics in Alzheimer's disease

scientific article

Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid

scientific article published on 27 June 2014

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

scientific article published on 12 April 2019

First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression

scientific article

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

scientific article

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments

Identification of novel APP/Abeta isoforms in human cerebrospinal fluid

scientific article

Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid

scientific article published on 25 June 2009

Increased CSF neurogranin concentration is specific to Alzheimer disease

scientific article published on 29 January 2016

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides

scientific article published on 28 February 2018

Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment

scientific article

Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ.

scientific article published on 2 November 2017

Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease

scientific article

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

scientific article published on 24 April 2010

Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-β in cerebrospinal fluid

scientific article

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

scientific article published on 18 December 2012

Multiplexing and multivariate analysis in neurodegeneration

scientific article published on 25 February 2012

Neurochemical Aftermath of Repetitive Mild Traumatic Brain Injury

scientific article published on 19 September 2016

Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke

scientific article published on 29 December 2018

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease

scientific article

Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment

scientific article published on January 2011

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.

scientific article published on 13 December 2018

P3-071: Mass spectrometric characterization of tau in cerebrospinal fluid

Pathways to Alzheimer's disease

scientific article published on March 2014

Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg

scientific article published on 28 February 2020

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease

scientific article published on 6 March 2017

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

scientific article published on 07 July 2016

Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability

scientific article published on 30 June 2015

Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an update

scientific article published on 25 September 2017

Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases

scientific article published on January 2009

Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease

scientific article

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum

scientific article published on 08 January 2013

Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET.

scientific article published on 31 August 2016

Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.

scientific article published on August 2012

Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass spectrometry

scientific article published on 21 July 2015

Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease

scientific article

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production

scientific article

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid

scientific article

Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease

scientific article

Specific Triazine Herbicides Induce Amyloid-β42 Production

scientific article

Synaptic retrogenesis and amyloid-beta in Alzheimer's disease

scientific article

Targeted proteomics in Alzheimer's disease: focus on amyloid-beta

scientific article published on April 2008

Tau as a molecular biomarker in cerebrospinal fluid and plasma

article published in 2014

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

scientific article published on March 2017

The amyloid-β degradation pattern in plasma--a possible tool for clinical trials in Alzheimer's disease

scientific article

The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease

scientific article

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Update on biomarkers for amyloid pathology in Alzheimer's disease

scientific article published on 15 June 2018

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

scientific article published on 17 November 2014

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