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List of works by Nils Y. Lycke

A novel concept in mucosal adjuvanticity: The CTA1‐DD adjuvant is a B cell‐targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit ⬇️

scientific article published on June 1, 1998

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus ⬇️

scientific article published on April 8, 2011

A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development

scientific article published on 3 January 2011

ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity

scientific article

ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization

scientific article published on 8 February 2010

Accelerated acute rejection of the intestinal graft in CD28-deficient mice

scientific article

Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.

scientific article published in February 1999

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.

scientific article

Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching.

scientific article

Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization ⬇️

scientific article published on January 1, 1992

Blockade of the B7-CD28 pathway by CTLA4-Ig counteracts rejection and prolongs survival in small bowel transplantation

scientific article published on 01 March 2000

B‐cell‐deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis ⬇️

scientific article published on December 1, 1997

CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches

scientific article published on 01 July 2000

CD4+ T‐cell immunity in the female genital tract is critically dependent on local mucosal immunization ⬇️

scientific article published on September 1, 2011

CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin

scientific article published on 01 February 1996

CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

scientific article published in December 2008

CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen

scientific article published on 01 September 2001

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

scientific article

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo

scientific article published on 01 January 1989

Cholera antibody production in vitro by peripheral blood lymphocytes following oral immunization of humans and mice

scientific article published in October 1985

Cholera toxin adjuvant greatly promotes antigen priming of T cells

scientific article published on 01 September 1993

Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization ⬇️

scientific article published on March 1, 1992

Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems

scientific article

Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells

scientific article published on April 1993

Cholera toxin enhances antigen presentation.

scientific article published on January 1995

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

scientific article published on May 1991

Circulating cholera antitoxin memory cells in the blood one year after oral cholera vaccination in humans

scientific article published in August 1987

Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant ⬇️

scientific article published on August 31, 2011

Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

scientific article published on 10 July 2015

Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection

scientific article

Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis

scientific article published on 25 September 2015

From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance

scientific article

Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant

scientific article published on 7 April 2010

Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

scientific article

Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response

scientific article published on March 1997

Graft mucosal blood flow is reduced prior to histologic evidence of rejection in mouse small bowel transplantation: a murine model

scientific article published on 01 March 2003

Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.

scientific article

Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection

scientific article published in April 2004

Host defense against cholera toxin is strongly CD4+ T cell dependent.

scientific article published on October 1991

IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection

scientific article published on 01 June 1996

IgA B Cell Responses to Gut Mucosal Antigens: Do We Know it all?

scientific article

IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice.

scientific article

IgA isotype restriction in the mucosal but not in the extramucosal immune response after oral immunizations with cholera toxin or cholera B subunit

scientific article published on 01 January 1983

Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling.

scientific article published on 24 December 2013

Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology

scientific article

Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching

scientific article published on 01 January 2001

Impaired mucosal immune responses in interleukin 4-targeted mice

scientific article published on 01 January 1995

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

scientific article published on 12 June 2006

Induction of gut IgA production through T cell-dependent and T cell-independent pathways

scientific article published on 19 January 2012

Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.

scientific article

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance ⬇️

scientific article published on 01 September 1997

Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin

scientific article published in May 1986

Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge

scientific article published on 21 June 2007

Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa ⬇️

scientific article published on January 15, 1998

Laser-Doppler flowmetry is reliable for early diagnosis of small-bowel acute rejection in the mouse

scientific article

Local intravaginal vaccination of the female genital tract

scientific article published on 01 October 1996

Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization

scientific article published on 01 April 1987

MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants

article

Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation

scientific article published on 30 July 2010

Migration of host and donor T cells in small bowel transplantation

scientific article published on 01 January 1997

Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin

scientific article published on May 1983

Mucosal Vaccine Development Based on Liposome Technology

scientific article published on 29 December 2016

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

scientific article published on 15 September 2010

Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action

scientific article published in January 1988

Mucosal immunity: implications for vaccine development

scientific article

Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.

scientific article published on 22 June 2007

Mucosal memory B cells retain the ability to produce IgM antibodies 2 years after oral immunization.

scientific article published in November 1995

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

scientific article

Oral vaccination with immune stimulating complexes.

scientific article published in January 1999

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.

scientific article

Per Brandtzaeg: patron of mucosal immunology

scientific article published in January 2017

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Presence of antigen-specific long-term memory cells in systemic lymphoid tissues as well as locally in the gut lamina propria following oral immunization with cholera toxin adjuvant.

scientific article published in January 1995

Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells

scientific article published in December 2002

Protection against cholera toxin after oral immunization is thymus-dependent and associated with intestinal production of neutralizing IgA antitoxin

scientific article published on 01 April 1987

Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen

scientific article published on December 2016

Recent progress in mucosal vaccine development: potential and limitations ⬇️

scientific article published on July 25, 2012

Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral imm_unization of mice against Helicobacter felis ⬇️

scientific article published on May 1, 1998

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice ⬇️

scientific article published on July 1, 1998

Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.

scientific article published in June 2009

Role of local IgA antitoxin-producing cells for intestinal protection against cholera toxin challenge

scientific article published on 01 January 1989

Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: dependence on the ADP-ribosyltransferase activity of the holotoxin

scientific article

Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant

scientific article published in October 1993

Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.

scientific article

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens

scientific article published on October 1986

Strong biotype and serotype cross-protective antibacterial and antitoxic immunity in rabbits after cholera infection

scientific article published on 01 August 1986

Strong differential regulation of serum and mucosal IgA responses as revealed in CD28-deficient mice using cholera toxin adjuvant

article

Studies in Knockout Mice Reveal that Anti‐Chlamydial Protection Requires TH1 Cells Producing IFN‐γ: Is this True for Humans? ⬇️

scientific article published on December 1, 1997

Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity

scientific article

T and B cell responses to chimeric proteins containing heterologous T helper epitopes inserted at different positions

scientific article published on October 1, 1992

T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.

scientific article published on 5 March 2010

Tandem repeats of t helper epitopes enhance immunogenicity of fusion proteins by promoting processing and presentation ⬇️

scientific article published on June 1, 1997

The ADP-Ribosylating CTA1-DD Adjuvant Enhances T Cell-Dependent and Independent Responses by Direct Action on B Cells Involving Anti-Apoptotic Bcl-2- and Germinal Center-Promoting Effects

article

The B cell targeted adjuvant, CTA1-DD, exhibits potent mucosal immunoenhancing activity despite pre-existing anti-toxin immunity

scientific article published on 01 March 2001

The B-cell targeted CTA1-DD vaccine adjuvant is highly effective at enhancing antibody as well as CTL responses

scientific article

The Female Lower Genital Tract Is a Privileged Compartment with IL-10 Producing Dendritic Cells and Poor Th1 Immunity following Chlamydia trachomatis Infection ⬇️

scientific article published on November 4, 2010

The Influence of Costimulation and Regulatory Cd4+ T Cells on Intestinal Iga Immune Responses ⬇️

scientific article published on January 1, 1998

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

scientific article published on June 1991

The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity

scientific article published on 01 September 1992

The immune complex CTA1-DD/IgG adjuvant specifically targets connective tissue mast cells through FcγRIIIA and augments anti-HPV immunity after nasal immunization

scientific article published on 10 April 2013

The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant

scientific article

The mechanism of cholera toxin adjuvanticity ⬇️

scientific article published on 01 October 1997

The mucosal adjuvant effects of cholera toxin and immune-stimulating complexes differ in their requirement for IL-12, indicating different pathways of action

scientific article published on 01 June 1999

The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization

scientific article published in February 2006

The regulation of gut mucosal IgA B-cell responses: recent developments

scientific article published on 26 July 2017

The role of Peyer's patches in synchronizing gut IgA responses

scientific article

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection

scientific article

Vaccine-induced immunity against Helicobacter pylori infection is impaired in IL-18-deficient mice

scientific article

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