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List of works by Robert Huber

1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase

scientific article published in July 2004

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

scientific article

A New Efficient Synthesis of Acetyltelluro- and Acetylselenomethionine and Their Use in the Biosynthesis of Heavy-Atom Protein Analogs

scientific article published in 1996

A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes

article

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

scientific article

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

scientific article published on 27 January 2020

Activation by substoichiometric inhibition

scientific article published on 06 January 2020

Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase

scientific article

Binding mode of TMC-95A analogues to eukaryotic 20S proteasome

scientific article published in September 2004

Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways

scientific article published on July 2004

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

scientific article (publication date: 14 February 2003)

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

scientific article published on 27 August 2002

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

scientific article published in January 2002

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

scientific article

Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class

scientific article

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

scientific article

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

scientific article

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

scientific article published in February 2002

Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease

scientific article

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

scientific article

Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.

scientific article

Conformational Variability of Chicken Cystatin

article

Conversion of a regulatory into a degradative protease

scientific article published on 22 February 2010

Crystal and molecular structure of human annexin V after refinement

article

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization

scientific article

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

scientific article

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

scientific article (publication date: 7 March 2003)

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

scientific article published on 4 November 2005

Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin

scientific article

Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis

scientific article

Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence

scientific article

Crystal structure of the C-terminal tetrad repeat from synexin (annexin VII) of Dictyostelium discoideum

article

Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family

scientific article

Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides

scientific article

Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization

scientific article (publication date: 16 May 2003)

Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain

scientific article

Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate

scientific article (publication date: 14 March 2003)

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

scientific article

Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity

scientific article

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

scientific article

Crystal structures of active SRC kinase domain complexes

scientific article published on October 2005

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

scientific article

Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations

scientific article published on 26 April 2005

Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities

scientific article

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

scientific article

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

scientific article published in August 2002

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

scientific article (publication date: March 2003)

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

scientific article published on 27 June 2010

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

scientific article

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

scientific article published on January 10, 2011

Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis

scientific article

Erratum: corrigendum: Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

scientific article published in Nature

Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea

scientific article published on October 2004

Fluoroprolines as Tools for Protein Design and Engineering We thank Mrs. E. Weyher for skillful technical assistance in spectroscopic analyses and Mrs. W. Wenger for her excellent technical assistance in protein preparation. We are indebted to Dr. R

scientific article published on 01 March 2001

Formation of metal nanoclusters on specific surface sites of protein molecules

scientific article published on August 2002

Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).

scientific article

Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors

scientific article published in November 2002

HTRA proteases: regulated proteolysis in protein quality control

scientific article published on 16 February 2011

High-level Biosynthetic Substitution of Methionine in Proteins by its Analogs 2-Aminohexanoic Acid, Selenomethionine, Telluromethionine and Ethionine in Escherichia coli

article published in 1995

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

scientific article

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates

scientific article published on 25 April 2012

Hydroxyureas as Noncovalent Proteasome Inhibitors ⬇️

scientific article published on November 21, 2011

IR laser-induced protein crystal transformation

scientific article

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

scientific article published in October 2002

Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin

scientific article

Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation

scholarly article

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

scholarly article

Investigations on the maturation and regulation of archaebacterial proteasomes

scientific article (publication date: 14 March 2003)

Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV

scientific article (publication date: 2003)

Molecular machines for protein degradation

scientific article

Molecular structure of the rod domain of dictyostelium filamin

scientific article

Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)

scientific article

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

scientific article

Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major

scientific article

Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation.

scientific article

Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates

scientific article

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

scientific article

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

scientific article

Protein quality control in the bacterial periplasm

scientific article published on January 2011

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

scientific article published in February 2002

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

scientific article

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

scientific article

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

scientific article

Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution

scientific article

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

scientific article

Structural and functional analysis of the natural JNK1 inhibitor quercetagetin

scientific article

Structural and functional studies of the yeast class II Hda1 histone deacetylase complex

scientific article

Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3

scientific article

Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda

scholarly article

Structural basis for the processive protein degradation by tricorn protease

scientific article published on 01 July 2002

Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase

scientific article published in November 2004

Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

scientific article (publication date: 16 May 2003)

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases

scientific article

Structural basis of the activation and action of trypsin

article

Structural basis of the adaptive molecular recognition by MMP9

scientific article

Structural basis of the zinc inhibition of human tissue kallikrein 5

scientific article

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

article

Structure and Properties of an Engineered Transketolase from Maize

scientific article

Structure and function of threonine synthase from yeast

scientific article

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

scientific article

Structure of MrsD, an FAD-binding protein of the HFCD family

scientific article

Structure of lumazine protein, an optical transponder of luminescent bacteria

scientific article

Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease

scientific article

Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli

scientific article

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

scientific article published on 18 August 2009

Structure-kinetic relationship study of CDK8/CycC specific compounds

scientific article

Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

scientific article published on 7 February 2005

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

scientific article

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine

scientific article

Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond

scientific article published in September 2005

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

scientific article

Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines

scientific article

The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity

scientific article

The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase

scientific article

The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link

scientific article

The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm

scientific article published in March 2004

The 2.0A resolution structure of the catalytic portion of a cyanobacterial membrane-bound manganese superoxide dismutase

scientific article

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus ⬇️

scientific article published on March 26, 1998

The core structure of TMC-95A is a promising lead for reversible proteasome inhibition

scientific article

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

scientific article (publication date: 29 April 2003)

The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region

scientific article

The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase

scientific article

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

scientific article

The crystal structure of the rare-cutting restriction enzyme SdaI reveals unexpected domain architecture.

scientific article published on September 2006

The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A

scientific article

The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket

scientific article published on 20 April 2005

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved

scientific article published in October 2002

The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage

scientific article

The persisting challenge of selective and specific proteasome inhibition

scientific article published on February 2009

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase

scientific article

The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.

scientific article

X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum

scientific article published in July 2005

X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases

scientific article

X-ray structures of Sap1 and Sap5: structural comparison of the secreted aspartic proteinases from Candida albicans

scientific article

X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition

scientific article published on 28 December 2005

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