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List of works by Didier Desmaële

"Squalenoylcurcumin" nanoassemblies as water-dispersible drug candidates with antileishmanial activity

scientific article published on 18 December 2014

7-Carboxylato-8-hydroxy-2-methylquinolinium monohydrate and 7-carboxy-8-hydroxy-2-methylquinolinium chloride monohydrate at 100 K.

scientific article

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

scientific article

A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water

scientific article published on 24 March 2020

A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer

scientific article

A comprehensive study of the spontaneous formation of nanoassemblies in water by a "lock-and-key" interaction between two associative polymers

scientific article

A methodology to study intracellular distribution of nanoparticles in brain endothelial cells

scientific article published in July 2005

A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types

scientific article

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation

scientific article published on 10 May 2019

Albumin-driven disassembly of lipidic nanoparticles: the specific case of the squalene-adenosine nanodrug

scientific article published on 21 January 2020

An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance

scientific article

Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip system

scientific article

Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies

scientific article published on 2 April 2013

Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor

scientific article

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer

scientific article published on May 2015

Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer

scientific article published on 26 June 2015

Asymmetric Michael reaction involving chiral imines/secondary enamines: stereocontrolled synthesis of 2,2-disubstituted tetrahydrothiophen-3-ones

scientific article published in July 2004

Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-L-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells

scientific article

Chemistry and structure-activity relationship of the styrylquinoline-type HIV integrase inhibitors.

scientific article published on 27 April 2010

Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells

scientific article published on 9 June 2017

Combination of three metals for the treatment of cancer: gallium, rhenium and platinum. 1. Determination of the optimal schedule of treatment

scientific article published on July 1, 2012

Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma

scientific article published on 14 July 2020

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

scientific article

Design of Rhenium Compounds in Targeted Anticancer Therapeutics

scientific article published on 01 January 2019

Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue

scientific article

Dose Effect of Rhenium (I)-diselenoether as Anticancer Drug in Resistant Breast Tumor-bearing Mice After Repeated Administrations

scientific article published on November 2016

Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer

scientific article published on 28 March 2018

Effects of Silencing theRET/PTC1Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol ⬇️

scientific article published on January 9, 2014

Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations

scientific article

Experimental/theoretical electrostatic properties of a styrylquinoline-type HIV-1 integrase inhibitor and its progenitors

scientific article published in January 2006

Gemcitabine-based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies

scientific article

Highly Porous Hybrid Metal-Organic Nanoparticles Loaded with Gemcitabine Monophosphate: a Multimodal Approach to Improve Chemo- and Radiotherapy

scientific article published on 17 December 2019

Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase

scientific article published on 15 March 2010

Improving the Antitumor Activity of Squalenoyl‐Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene ⬇️

scientific article published on December 4, 2012

In Vitro Activities of New 2-Substituted Quinolines against Leishmania donovani ⬇️

scientific article published on January 10, 2011

In Vivo FRET Imaging to Predict the Risk Associated with Hepatic Accumulation of Squalene-Based Prodrug Nanoparticles

scientific article published on 30 November 2017

Interaction of a new anticancer prodrug, gemcitabine-squalene, with a model membrane: coupled DSC and XRD study

scientific article published on 7 May 2010

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide

scientific article published on 29 March 2016

Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

scientific article

Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery ⬇️

scientific article published on March 15, 2012

Lipid-Conjugation of Endogenous Neuropeptides: Improved Biotherapy against Human Pancreatic Cancer

scientific article published on 18 February 2015

Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation ⬇️

scientific article published on July 5, 2010

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach.

scientific article

Nanotechnologies for the treatment of colon cancer: From old drugs to new hope

scientific article published on November 2016

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

scientific article published in November 2016

New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity

scientific article published in September 2005

Novel PEGylated Nanoassemblies Made of Self-Assembled Squalenoyl Nucleoside Analogues

Novel self assembling nanoparticles for the oral administration of fondaparinux: synthesis, characterization and in vivo evaluation

scientific article

Osteotropic polypeptide nanoparticles with dual hydroxyapatite binding properties and controlled cisplatin delivery

scientific article published on 12 December 2014

PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma

scientific article published on 4 August 2016

PLGA-PEG-supported Pd Nanoparticles as Efficient Catalysts for Suzuki-Miyaura Coupling Reactions in Water

scientific article published in January 2016

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor

scientific article published on 28 June 2014

Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis

scientific article published on 16 June 2015

Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy

scientific article published on 27 August 2012

Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy

scientific article published on 18 July 2013

Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine

scientific article published on 7 February 2008

Quantification of dimethyl-ifosfamide and its N-deschloropropylated metabolites in mouse plasma by liquid chromatography–tandem mass spectrometry ⬇️

scientific article published on February 13, 2011

Revisiting absorption and electronic circular dichroism spectra of cholesterol in solution: a joint experimental and theoretical study

scientific article

Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

scientific article published on 29 November 2019

Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections

scientific article

Self-assembly of polyisoprenoyl gemcitabine conjugates: influence of supramolecular organization on their biological activity

scientific article published on 30 May 2014

Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles

scientific article published on 20 November 2013

Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method

Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tunable Drug Delivery Properties

article by Yinyin Bao et al published 22 August 2016 in Chemistry of Materials

Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics

scientific article published on 28 January 2011

Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury.

scientific article

Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms

scientific article published on November 2008

Squalenoyl nanomedicines as potential therapeutics

scientific article published on November 2006

Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues

scientific article published on 20 March 2010

Squalenoylation of Chitosan: A Platform for Drug Delivery?

scientific article published on 29 July 2015

Squalenoylation: A generic platform for nanoparticular drug delivery ⬇️

scientific article published on 04 August 2011

Stereochemical Aspects in the Asymmetric Michael Addition of Chiral Imines to Substituted Electrophilic Alkenes ⬇️

scientific article published on June 26, 1996

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

scientific article

Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

scientific article published on 6 June 2016

Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma

scientific article published on 18 May 2011

The role of solvent swelling in the self-assembly of squalene based nanomedicines

scientific article

Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy

scientific article

Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis

scientific article

Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood–Brain Barrier

Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells

scientific article published on 20 April 2015

Uptake and efflux of rhenium in cells exposed to rhenium diseleno-ether and tissue distribution of rhenium and selenium after rhenium diseleno-ether treatment in mice

scientific article published on April 2014

Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines

scientific article published on October 2002

X-ray microfluorescence for biodistribution studies of nanomedicines

scientific article published on 26 August 2017

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