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List of works by Ana I Rojo

A role for APP in Wnt signalling links synapse loss with β-amyloid production

scientific article published on 20 September 2018

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. ⬇️

scientific article

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.

scientific article published on 11 July 2018

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

scientific article

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease

scientific article

Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease.

scientific article published on April 2014

GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.

scientific article published on 13 November 2007

Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.

scientific article

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

scientific article (publication date: 10 January 2017)

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease.

scientific article

Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress.

scientific article

Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.

scientific article published on 28 March 2011

Redox control of microglial function: molecular mechanisms and functional significance

scientific article

Regulation of Cu/Zn-Superoxide Dismutase Expression via the Phosphatidylinositol 3 Kinase/Akt Pathway and Nuclear Factor- B

scientific article published on 01 August 2004

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

scientific article published on 18 January 2011

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.

scientific article published on 11 February 2004

The PTEN/NRF2 axis promotes human carcinogenesis

scientific article

The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection.

scientific article published on 12 June 2009

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

scientific article published on 01 April 2019

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.

scientific article published in April 2018

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.

scientific article published on 18 July 2016

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

scientific article published on 26 July 2018

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus.

scientific article

WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.

scientific article

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