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List of works by Stuart C. Sealfon

A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites

scientific article published in Journal of Biological Chemistry

A New Family of Boucher-Neuhauuser Syndrome: Coexistence of Holmes Type Cerebellar Atrophy, Hypogonadotropic Hypogonadism and Retinochoroidar Degeneration: Case Reports and Review of Literature ⬇️

scientific article published on June 1, 1995

A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants

scientific article

A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood.

scientific article

A first update on mapping the human genetic architecture of COVID-19

scientific article published on 3 August 2022

A novel calcium-dependent chloride current in Xenopus oocytes injected with brain messenger RNA.

scientific article

A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript

scientific article (publication date: July 1999)

A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor

scientific article published on 01 February 1994

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

scientific article published on 25 April 2022

Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays

scientific article published on May 2002

Activation of ionic currents in Xenopus oocytes by corticotropin-releasing peptides

scientific article published in November 1988

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

scientific article published on July 2003

Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia

scientific article published in April 2005

Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor

scientific article published on 11 September 2003

Agonist-trafficking and hallucinogens.

scientific article

Alternative transcripts of the rat and human dopamine D3 receptor

scientific article published in October 1991

Antibody Responses to SARS-CoV-2 Following an Outbreak Among Marine Recruits With Asymptomatic or Mild Infection

scientific article published on 09 June 2021

Antiviral response dictated by choreographed cascade of transcription factors.

scientific article

Antiviral-activated dendritic cells: a paracrine-induced response state

scientific article

Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19

scientific article published on 05 April 2022

Attenuated activation of pulmonary immune cells in mRNA-1273–vaccinated hamsters after SARS-CoV-2 infection

scientific article published in 2021

Authors response to correspondence about an improved compensation method.

scientific article published on 7 November 2011

BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development

scientific article

BioPP: a tool for web-publication of biological networks

scientific article

Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats

scientific article published on 07 February 2007

Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease

scientific article published in 2023

Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription.

scientific article published on February 2007

CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis.

scientific article published on 17 March 2005

Cell-to-cell communication: time and length scales of ligand internalization in cultures of suspended cells.

scientific article published on June 2008

CellCODE: a robust latent variable approach to differential expression analysis for heterogeneous cell populations.

scientific article published on 11 January 2015

Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression

scientific article published on 27 July 2016

Characterization of a MAPK scaffolding protein logic gate in gonadotropes.

scientific article

Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells

scientific article published on 2 August 2007

Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo

scientific article published in December 2005

Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice.

scientific article published on 16 January 2013

Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study

scientific article published in 2024

Cloning and characterization of the human GnRH receptor

scientific article

Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor

scientific article published on July 1, 1992

Combinatorial cytokine code generates anti-viral state in dendritic cells

scientific article published on 26 February 2014

Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism

scientific article published on 14 August 2015

Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors.

scientific article published on October 1993

Comparing Host Module Activation Patterns and Temporal Dynamics in Infection by Influenza H1N1 Viruses

scientific article published on 14 July 2021

Computational approaches to understanding dendritic cell responses to influenza virus infection

scientific article

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

scientific article published on 26 July 2002

Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor

scientific article

Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus

scientific article published on July 1996

Coregulation mapping based on individual phenotypic variation in response to virus infection

scientific article

Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification

article

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

scientific article published in July 2006

Coupling of GnRH concentration and the GnRH receptor-activated gene program

scientific article

Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins

scientific article

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells

scientific article

Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19

scientific article published on 28 May 2021

Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines

scientific article published on 25 March 2019

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation

scientific article published on 19 November 2012

D1 dopamine receptor regulation of microtubule-associated protein-2 phosphorylation in developing cerebral cortical neurons.

scientific article

Deciphering the combinatorial landscape of immunity

scientific article published on 23 November 2020

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

scientific article

Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1

scientific article published on 12 December 2019

Differential gene expression in patients with amyotrophic lateral sclerosis

scientific article

Distribution of dopamine D2 receptor mRNA splice variants in the rat by solution mhybridization/protection assay ⬇️

scientific article published on January 14, 1991

Dopamine D2-receptor messenger RNA is differentially regulated by dopaminergic agents in rat anterior and neurointermediate pituitary

scientific article published on 01 November 1989

Dopamine receptors and locomotor responses: molecular aspects

scientific article

Dopamine receptors: from structure to behavior

scientific article

Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress

scientific article published on 12 April 2004

Effective use of microarrays in neuroendocrine research

scientific article published on March 2007

Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter ⬇️

scientific article published on August 1, 1991

Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

scientific article

Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain.

scientific article published in January 2005

Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia.

scientific article published in March 2000

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Focused microarray analysis

scientific article published on December 2003

Functional Microdomains in G-protein-coupled Receptors

scientific article published in Journal of Biological Chemistry

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors

scientific article

Functional domains of the gonadotropin-releasing hormone receptor.

scientific article published on February 1995

Functional expression of brain cholecystokinin and bombesin receptors in Xenopus oocytes

scientific article published on 01 August 1988

Functional selectivity in GPCR heterocomplexes.

scientific article published on August 2012

G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope

scientific article

Genomics view of gonadotrope signaling circuits.

scientific article published in September 2004

Getting started in biological pathway construction and analysis.

scientific article

Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone.

scientific article published on September 1994

Gonadal hormones and gonadotropin-releasing hormone (GnRH) alter messenger ribonucleic acid levels for GnRH receptors in sheep

scientific article published in April 1994

Gonadotropin-releasing hormone receptor expression in Xenopus oocytes

scientific article published on January 1990

Gonadotropin-releasing hormone receptor-coupled gene network organization

scientific article

Group II metabotropic glutamate receptors and schizophrenia

scientific article published on 26 August 2009

Growth differentiation factor 9 (GDF9) forms an incoherent feed-forward loop modulating follicle-stimulating hormone β-subunit (FSHβ) gene expression.

scientific article

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

scientific article

Heterogeneous distribution of D1, D2 and D5 receptor mRNAs in monkey striatum

scientific article published in July 1993

Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages

scientific article published on 13 August 2020

Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics

scientific article

High resolution annotation of zebrafish transcriptome using long-read sequencing.

scientific article published on 30 July 2018

Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression

scientific article

Homologous up-regulation of the gonadotropin-releasing hormone receptor in alpha T3-1 cells is associated with unchanged receptor messenger RNA (mRNA) levels and altered mRNA activity

scientific article published on December 1993

Hormonal regulation of gonadotropin-releasing hormone receptors and messenger RNA activity in ovine pituitary culture

scientific article published in December 1990

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

scientific article

Hybrid Bayesian-rank integration approach improves the predictive power of genomic dataset aggregation

scientific article published on 29 September 2014

Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding

scientific article published on February 1995

Identification of Three Putative GnRH Receptor Subtypes in Vertebrates

scientific article published on 01 December 1998

Identification of a serotonin/glutamate receptor complex implicated in psychosis

scientific article

Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function

scientific article

Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.

scientific article

Improved compensation in flow cytometry by multivariable optimization.

scientific article published on 11 April 2011

Increasing consistency of disease biomarker prediction across datasets

scientific article

Influenza virus evades innate and adaptive immunity via the NS1 protein

scientific article published on July 2006

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

scientific article published on 30 September 2019

Insertional mutagenesis of the arginine cage domain of the gonadotropin-releasing hormone receptor

scientific article

Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases

scientific article

Interclass GPCR heteromerization affects localization and trafficking

scientific article published on 20 October 2020

Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus

scientific article

Interpretation of an individual functional genomics experiment guided by massive public data

scientific article published on 26 November 2018

Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells

scientific article

Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

scientific article published in June 2005

Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum

scientific article published in October 1992

Low-variance RNAs identify Parkinson's disease molecular signature in blood

scientific article published on 18 March 2015

MOCCASIN: converting MATLAB ODE models to SBML.

scientific article published on 9 February 2016

Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin

scientific article published on June 1996

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

scientific article

Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization

scientific article

Microtranscriptome regulation by gonadotropin-releasing hormone

scientific article

Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression

scientific article published on 01 June 2004

Misty Mountain clustering: application to fast unsupervised flow cytometry gating

scientific article

Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone.

scientific article

Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication

scientific article

Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.

scientific article

Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency

scientific article

Modulation of calcium mobilization by guanosine 5'-O-(2-thiodiphosphate) in Xenopus oocytes

scientific article published in August 1990

Module dynamics of the GnRH signal transduction network.

scientific article published in October 2002

Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

scientific article published on January 2003

Molecular function of the gonadotropin-releasing hormone receptor: insights from site-directed mutagenesis.

scientific article published on April 1994

Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor

scientific article published on April 1997

Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction

scientific article published on January 2002

Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent

scientific article published on 28 November 2012

Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation

scientific article

Multiple Interactions of the Asp2.61(98)Side Chain of the Gonadotropin-Releasing Hormone Receptor Contribute Differentially to Ligand Interaction†

article

Multiple testing and its applications to microarrays.

scientific article

Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development

scientific article

Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.

scientific article

Noise propagation and scaling in regulation of gonadotrope biosynthesis.

scientific article

Noise propagation through extracellular signaling leads to fluctuations in gene expression.

scientific article

Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study

scientific article

Nuclear translocation of GAPDH-GFP fusion protein during apoptosis

scientific article published on 01 April 1999

Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes

scientific journal article

Optimized protocol for efficient transfection of dendritic cells without cell maturation

scientific article published on 08 July 2011

Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation

scientific article published on 28 August 2013

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.

scientific article

Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice

scientific journal article

Pathway-level information extractor (PLIER) for gene expression data

scientific article published on 27 June 2019

Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice

scientific article published on 28 July 2012

Pharmacology of a capacitative Ca2+ entry in Xenopus oocytes

scientific article published in August 1996

Physiological Adaptations to Progressive Endurance Exercise Training in Adult And Aged Rats: Insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC)

scientific article published on 26 March 2024

Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows

scientific article

Polymorphisms 'r us

scientific article published on 01 April 2001

Power-laws in interferon-B mRNA distribution in virus-infected dendritic cells.

scientific article published on October 2009

Protocol for high-throughput DNA methylation profiling in rat tissues using automated reduced representation bisulfite sequencing

scholarly article

Psychedelics and schizophrenia

scientific article

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

scientific article published on 15 June 2016

RNA and DNA Microarrays ⬇️

scientific article published on 01 January 2011

Receptor pair for schizophrenia.

scientific article published on July 2008

Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection.

scientific article

Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine

scientific article published in September 1993

Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone.

scientific article published on 14 February 2018

Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson's Disease

scientific article published on 17 June 2020

Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor

scientific article published on 01 July 1995

Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase.

scientific article

Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

scientific article

Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells

scientific article

SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures

scientific article published in November 2022

SARS-CoV-2 Transmission among Marine Recruits during Quarantine

scientific article published on 11 November 2020

SAT-414 Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines.

scientific article published on 30 April 2019

SOME STEP-DOWN PROCEDURES CONTROLLING THE FALSE DISCOVERY RATE UNDER DEPENDENCE.

scientific article published on January 2008

Sequence alignment of the G-protein coupled receptor superfamily

scientific article published on January 1, 1992

Shared kinase fluctuations between two enzymatic reactions

scientific article published on 7 November 2008

Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase

scientific article

Single nucleus multi-omics regulatory landscape of the murine pituitary

scientific article published on 11 May 2021

Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms

scientific article published in March 2022

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection.

scientific article published on 10 February 2015

Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity

article

Single-cell transcriptional profiles in human skeletal muscle

scientific article published on 14 January 2020

Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson's disease

scientific article published on 12 December 2019

Solving Immunology?

scientific article published on 13 December 2016

Spatio-temporal dynamics of Host-Virus competition: A model study of influenza A

scientific article published on 28 September 2019

Strategies for mapping the binding site of the serotonin 5-HT2A receptor

scientific article published in January 2002

Structure of the GnRH receptor-stimulated signaling network: insights from genomics

scientific article published on July 2003

Structure of the mouse gonadotropin-releasing hormone receptor gene: variant transcripts generated by alternative processing

scientific article published on June 1994

Teaching resources. G-protein-coupled receptors

scientific article published on 12 April 2005

Tellurium Notebooks - An Environment for Dynamical Model Development, Reproducibility, and Reuse

article

Tellurium notebooks-An environment for reproducible dynamical modeling in systems biology.

scientific article published on 15 June 2018

The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor

scientific article published in Journal of Biological Chemistry

The gonadotrophin-releasing hormone receptor: structural determinants and regulatory control

scientific article published on May 1995

The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells

scientific article

Time and length scales of autocrine signals in three dimensions.

scientific article

Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone.

scientific article published on 16 June 2005

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex ⬇️

scientific article published on October 1, 2003

Translational regulation of the gonadotropin-releasing hormone receptor in alpha T3-1 cells

scientific article published on March 1995

Understanding multicellular function and disease with human tissue-specific networks

scientific article published on 27 April 2015

Validated genomic approach to study differentially expressed genes in complex tissues.

scientific article published on October 2002

Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation ⬇️

scientific article published on September 24, 2010

flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding

scientific article

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

scientific journal article

β-catenin regulates GnRH-induced FSHβ gene expression.

scientific article published on 04 December 2012

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