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List of works by Gunhild M. Mælandsmo

A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases

A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth

scientific article

AXL inhibition improves BRAF-targeted treatment in melanoma

scientific article published on 24 March 2022

Abstract 1093: Legumain in colorectal cancer: Unorthodox localization and trafficking

article

Abstract 927: Fibroblast-induced switching to the invasive phenotype and PI3K-mTOR signaling protects melanoma cells from BRAF inhibitors

scientific article published on 26 July 2016

Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes

scientific article

Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma

scientific article

Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation

scientific article (publication date: 14 August 2003)

Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity

scientific article published on October 2001

Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: A correlation study between micro-computed tomography angiography and dynamic contrast enhanced MRI.

scientific article

Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model

scientific article

Antitumor activity of elacytarabine combined with bevacizumab, cetuximab and trastuzumab in human NSCLC xenografts.

scientific article published in September 2013

Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer

scientific article published in 2021

B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation

scientific article published on 25 April 2011

B7‐H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis‐associated genes ⬇️

scientific article published on August 8, 2011

Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4

scholarly article by Lina Prasmickaite et al published September 2018 in Molecular Oncology

Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma

scientific article

Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft

scientific article published on 04 December 2018

Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide

scientific article

Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases

scientific article

Clinical significance of disseminated tumour cells in non-small cell lung cancer

scientific article published on 13 August 2013

Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma

scientific article

Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner

scientific article published in December 2003

Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4.

scientific article

Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines

scientific article published on June 2007

Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model

Comment on the Importance of S100A4 in Regulation of MMP-13 ⬇️

scientific article published on December 31, 2010

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

scientific article

Correction: Nuclear Legumain Activity in Colorectal Cancer.

scientific article published on 19 September 2013

Cyclin A expression in superficial spreading malignant melanomas correlates with clinical outcome ⬇️

scientific article published on 01 December 2001

Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: reduced expression in metastatic lesions

scientific article published on December 1996

Cystatin E/M suppresses legumain activity and invasion of human melanoma

scientific article

Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

scientific article

Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma

scientific article

Design, synthesis and biological evaluation of 6-substituted quinolines derived from cabozantinib as c-Met inhibitors

scientific article published on 15 August 2019

Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer

scientific article published on 17 June 2016

Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen

scientific article published on 01 May 2021

Didanosine ester prodrugs: synthesis, albumin binding properties and pharmacokinetic studies in rats.

scientific article published on 14 April 2009

Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites

scientific article published on 5 February 2009

Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma

scientific article published on August 1997

Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft

scientific article

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

scientific article

Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer

scientific article published on 05 March 2020

Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response

scientific article published on 21 March 2017

Dynamic (18)F-FDG-PET for monitoring treatment effect following anti-angiogenic therapy in triple-negative breast cancer xenografts

scientific article published on 29 August 2013

Dynamic (18) F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts

scientific article

Dynamic 2-Deoxy-2-[18F]Fluoro-D-Glucose Positron Emission Tomography for Chemotherapy Response Monitoring of Breast Cancer Xenografts

scientific article

ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion

scientific article published on 18 March 2020

EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer

scientific article

EMT-Derived Alterations in Glutamine Metabolism Sensitize Mesenchymal Breast Cells to mTOR Inhibition

scientific article published in 2021

Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein geneEGP-2

article

Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts

scientific article published on 31 March 2012

Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins.

scientific article published on 22 March 2018

Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes

scientific article published on 9 September 2015

Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma

scientific article

Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53.

scientific article published on 24 February 2010

Evaluation of serum osteopontin level and gene polymorphism as biomarkers: analyses from the Nordic Adjuvant Interferon alpha Melanoma trial

scientific article published on 02 April 2015

Expression and clinical significance of Wee1 in colorectal cancer

scientific article published on 24 May 2016

Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer

scientific article published on 01 October 2007

Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma

scientific article

Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies

scientific article published on November 2002

Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer

scientific article

Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells

scientific article published in October 2000

Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome

scientific article published in September 2004

Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcome ⬇️

scientific article published on 01 November 2003

Expression of matrix metalloproteinases and the metastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cells.

scientific article

Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors

scientific article published on 24 February 2016

From autonomy to community; new perspectives on tumorigenicity and therapy resistance

scientific article

Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

scientific article published on 14 May 2019

HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR.

scientific article published on 21 December 2015

Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

scientific article

High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting

High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases

article

Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1.

scientific article

Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells

scientific article published on 13 March 2010

Human osteosarcoma xenografts and their sensitivity to chemotherapy

scientific article published on 25 September 2004

Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum

scientific article published in January 2004

Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate.

scientific article

In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts

scientific article

In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts

scientific article published on 14 February 2014

Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells

scientific article

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

scientific article published on 29 March 2017

Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest

scientific article published in June 2003

Interferon-gamma-induced suppression of S100A4 transcription is mediated by the class II transactivator

scientific article published on 12 December 2006

Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL.

scientific article published on September 1998

Interplay of choline metabolites and genes in patient-derived breast cancer xenografts

scientific article published on 21 January 2014

Interrogating open issues in cancer medicine with patient-derived xenografts

scientific article published on 15 September 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M.

scientific article

Intracellular metabolism of a 2'-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or asfree ribozyme. A study by capillary electrophoresis

scientific article published on September 1998

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas

scientific article

Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease.

scientific article published on 13 July 2018

Levels of cyclin D1 and D3 in malignant melanoma: deregulated cyclin D3 expression is associated with poor clinical outcome in superficial melanoma

scientific article published on 01 September 2000

Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression ⬇️

scientific article published on 01 November 1992

Light directed gene transfer by photochemical internalisation.

scientific article

Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy

scientific article published in April 2002

Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions

scientific article

Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism

scientific article published on 5 December 2015

Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis

scientific article published on 28 November 2012

Low-molecular contrast agent dynamic contrast-enhanced (DCE)-MRI and diffusion-weighted (DW)-MRI in early assessment of bevacizumab treatment in breast cancer xenografts

scientific article published on 21 March 2013

Lysine methylation of VCP by a member of a novel human protein methyltransferase family

scientific article

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

scientific article published on 01 September 1994

Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2.

scientific article published on December 1993

Matrix metalloproteinases participate in osteosarcoma invasion

scientific article

Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers

scientific article published in November 2005

Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer

scientific article published on 28 February 2013

Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition

scientific article

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

scientific article

Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties

scientific article published on 8 November 2013

MicroRNA in combination with HER2-targeting drugs reduces breast cancer cell viability in vitro

scientific article published on 25 May 2021

Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer.

scientific article published on 24 June 2013

Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models

scientific article published on 4 August 2009

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases.

scientific article

Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study

scientific article published on 25 March 2020

Novel human melanoma brain metastasis models in athymic nude fox1<sup>nu</sup> mice: Site-specific metastasis patterns reflecting their clinical origin

scientific article published on 06 October 2021

Nuclear S100A4 is a novel prognostic marker in colorectal cancer

scientific article published on 16 August 2010

Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells

scientific article published on 3 September 2015

Nuclear legumain activity in colorectal cancer

scientific article

Nuclear localization of the metastasis-related protein S100A4 correlates with tumour stage in colorectal cancer

scientific article published on 01 August 2003

O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes

scientific article published on 05 April 2019

Optimization of Hammerhead Ribozymes for the Cleavage of S100A4 (CAPL) mRNA

scholarly article by Eivind Hovig et al published April 2001 in Oligonucleotides

Osteopontin is a prognostic biomarker in non-small cell lung cancer

scientific article

Osteopontin--an important downstream effector of S100A4-mediated invasion and metastasis

scientific article

PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles.

scientific article published on May 2005

PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells.

scientific article published in January 2010

Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy

scientific article published on 06 August 2019

Patient-derived xenograft models: an emerging platform for translational cancer research

scientific article

Photochemical internalization: a new tool for drug delivery.

scientific article published on December 2007

Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus

scientific article published on June 2006

Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor

scientific article published in March 2006

Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines

scientific article published on 19 November 2006

Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin

scientific article published on 01 April 2020

Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin

scientific article published on 17 October 2014

Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21.

scientific article

Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts

scientific article published on 14 July 2014

Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma

scientific article published on 21 March 2019

Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy

scientific article published on 08 June 2016

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

scientific article published on 5 January 2017

Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients

scientific article published on 25 November 2020

Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival

scientific article published on July 1998

Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations

scientific article

Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts

scientific article published on 22 July 2013

Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

scientific article published on August 2003

Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression

scientific article

Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain

scientific article published on 25 February 2019

Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme

S100A4 and metastasis: a small actor playing many roles

scientific article

S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme.

scientific article published on September 1999

S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells

scientific article published on January 2003

S100B in bone marrow aspirates in healthy individuals and malignant melanoma patients

scientific article published in April 2008

STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer

scientific article published on 29 June 2010

STAMP2 increases oxidative stress and is critical for prostate cancer.

scientific article

STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo

scientific article published on 9 August 2016

Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4

scientific article

Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers

scientific article published on 08 October 2019

Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB

scientific article

Soluble AXL as a marker of disease progression and survival in melanoma

scientific article published on 09 January 2020

Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts.

scientific article

Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic value

scientific article published on 26 May 2007

Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics

scientific article published on 04 December 2019

Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment

scientific article published on 18 September 2018

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.

scientific article

Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts

scientific article published on 23 October 2012

Synthesis, characterization, and cellular uptake of magnetic nanocarriers for cancer drug delivery

scientific article published on 24 July 2014

TD-11 workshop report: characterization of monoclonal antibodies to S100 proteins

scientific article

Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma

scientific article published on 23 December 2019

Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells

scientific article published on July 2011

The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers

scientific article published on 28 January 2020

The metalloproteinase inhibitor TIMP-2 is down-regulated by androgens in LNCaP prostate carcinoma cells

scientific article published on January 2003

The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis

scientific article published on 31 December 2010

The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer

scientific article

The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas

scientific article published on December 1994

Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice

scientific article published on July 2004

Uptake of chylomicron remnant retinyl esters in human leukocytes in vivo

scientific article published on 01 April 1992

Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice

scientific article

Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases

scientific article published on 3 November 2016

Zebrafish as a model system for characterization of nanoparticles against cancer

scientific article published on 9 December 2015

hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma

scientific article published on 12 December 2016

p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance

scientific article published on 09 April 2019

pH-responsive nano carriers for doxorubicin delivery

scientific article published on 7 October 2014

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