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List of works by Steven Zeisel

A Brief History of Choline ⬇️

scientific article published on November 26, 2012

A Grand Challenge for Nutrigenomics ⬇️

scientific article published on December 13, 2010

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction ⬇️

scientific article published on November 8, 2010

Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level

scientific article published on April 2005

Adapting the contents of computer-based instruction based on knowledge tests maintains effectiveness of nutrition education

scientific article published in April 2003

Adiponectin Lowers Glucose Production by Increasing SOGA ⬇️

scientific article published on September 2, 2010

Adverse event associated with methionine loading test: a case report

scientific article

Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci

scientific article

Are dietary choline and betaine intakes determinants of total homocysteine concentration?

scientific article

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency

scientific article

Astronaut ophthalmic syndrome

scientific article published on 25 May 2017

BRCA1 promoter methylation is associated with increased mortality among women with breast cancer

scientific article published on 03 June 2008

Betaine supplementation and blood lipids: fact or artifact?

scientific article

CASAnova: a multiclass support vector machine model for the classification of human sperm motility patterns.

scientific article published on 4 October 2017

Choline Availability During Embryonic Development Alters Progenitor Cell Mitosis in Developing Mouse Hippocampus ⬇️

scientific article published on November 1, 2003

Choline Availability During Embryonic Development Alters the Localization of Calretinin in Developing and Aging Mouse Hippocampus ⬇️

scientific article published on April 1, 2003

Choline and betaine intake and the risk of colorectal cancer in men

scientific article

Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene

scientific article

Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene

scientific article

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load

scientific article published on February 2005

Choline deficiency increases lymphocyte apoptosis and DNA damage in humans

scientific article published on July 2006

Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function ⬇️

scientific article published on April 27, 2012

Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma

scientific article

Choline intake and risk of lethal prostate cancer: incidence and survival

scientific article

Choline metabolism and risk of breast cancer in a population-based study

scientific article

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression ⬇️

scientific article published on March 1, 2012

Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability

scientific article published on 16 September 2013

Choline's role in maintaining liver function: new evidence for epigenetic mechanisms

scientific article

Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria

scientific article published in December 2004

Choline: Clinical Nutrigenetic/Nutrigenomic Approaches for Identification of Functions and Dietary Requirements ⬇️

scientific article published on January 1, 2010

Choline: Dietary Requirements and Role in Brain Development

scientific article published on January 2007

Choline: an essential nutrient for public health

scientific article

Choline: critical role during fetal development and dietary requirements in adults

scientific article

Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia

scientific article

Common genetic polymorphisms affect the human requirement for the nutrient choline

scientific article

Concentrations of choline-containing compounds and betaine in common foods

scientific article

Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States

scientific article published on 22 December 2017

Contribution of Dietary Supplements to Nutritional Adequacy in Race/Ethnic Population Subgroups in the United States

scientific article published on 28 November 2017

Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups

scientific article published on 6 December 2017

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women ⬇️

scientific article published on April 10, 2013

Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells

scientific article

Deletion of Betaine-Homocysteine S-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas ⬇️

scientific article published on August 30, 2011

Deletion of murine choline dehydrogenase results in diminished sperm motility

scientific article

Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice

scientific article

Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus

scientific article published in April 2004

Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline

scientific article

Diet-Gene Interactions Underlie Metabolic Individuality and Influence Brain Development: Implications for Clinical Practice Derived from Studies on Choline Metabolism ⬇️

scientific article published on May 15, 2012

Dietary Modulation of the Epigenome

scientific article published in April 2018

Dietary choline and betaine and the risk of distal colorectal adenoma in women

scientific article

Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study

scientific article published on April 2006

Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains

scientific article published in January 2006

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones ⬇️

scientific article published on October 20, 2011

Dietary choline requirements of women: effects of estrogen and genetic variation

scientific article

Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain

scientific article

Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse

scientific article

Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not.

scientific article published on 8 September 2006

Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus

scientific article

Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells

scientific article published on 4 January 2007

Diethanolamine induces hepatic choline deficiency in mice

scientific article published in May 2002

Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans

scientific article

Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans

scientific article

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

scientific article

Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis, and estrogenic outcomes in healthy postmenopausal women: a phase I clinical trial

scientific article published on July 2008

Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts

scientific article published on July 2004

Epigenetic mechanisms for nutrition determinants of later health outcomes

scientific article

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort

scientific article published on 28 April 2015

Evidence-based criteria in the nutritional context

scientific article published on August 2010

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

scientific article published on 29 July 2015

Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain

scientific article

GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans

scientific article

Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice

scientific article

Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain

scientific article published on 09 December 2004

Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline

scientific article published on June 2007

Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models

scientific article published on 03 September 2008

Genetic signatures in choline and 1‐carbon metabolism are associated with the severity of hepatic steatosis ⬇️

scientific article published on January 4, 2013

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans

scientific article

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes

scientific article

High intakes of choline and betaine reduce breast cancer mortality in a population-based study

scientific article

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research

scientific article published on 5 October 2012

Homocysteine metabolism in ZDF (type 2) diabetic rats

scientific article published on November 2005

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency

scientific article

Homocysteinemia in Mice with Genetic Betaine HomocysteineS -Methyltransferase Deficiency Is Independent of Dietary Folate Intake ⬇️

scientific article published on September 26, 2012

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups

scientific article

Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults

scientific article published on 09 August 2017

Importance of methyl donors during reproduction

scientific article published on 30 December 2008

Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD) ⬇️

scientific article published on July 17, 2013

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

scientific article

Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet

scientific article published on 30 December 2008

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

scientific article published on 18 June 2015

Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not.

scientific article published on July 2007

Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus

scientific article

Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus

scientific article

Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring

scientific article published on 23 December 2015

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

scientific article

Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts

scientific article published on 2 December 2014

Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis ⬇️

scientific article published on March 1, 2013

Metabolomic Approaches to Explore Chemical Diversity of Human Breast-Milk, Formula Milk and Bovine Milk

scientific article (publication date: 17 December 2016)

Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

scientific article

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

scientific article published on 21 October 2016

Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes

scientific article published on May 2003

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue ⬇️

scientific article published on February 23, 2012

Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline

scientific article published on September 2007

Nutrition Education in U.S. Medical Schools: Latest Update of a National Survey ⬇️

scientific article published on September 1, 2010

Nutrition in medicine: nutrition education for medical students and residents

scientific article

Nutrition in pregnancy: the argument for including a source of choline ⬇️

scientific article published on April 22, 2013

Nutritional genomics: defining the dietary requirement and effects of choline

scientific article

Nutritional importance of choline for brain development

scientific article

People with fatty liver are more likely to have the PEMT rs7946 SNP, yet populations with the mutant allele do not have fatty liver

scientific article published in October 2006

Perinatal choline influences brain structure and function

scientific article

Perspectives from the symposium: The role of nutrition in infant and toddler brain and behavioral development

scientific article published on June 2008

Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro

scientific article

Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial

scientific article

Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes

scientific article

Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline

scientific article published on March 2003

Phosphatidylethanolamine-N-methyltransferase Activity and Dietary Choline Regulate Liver-Plasma Lipid Flux and Essential Fatty Acid Metabolism in Mice ⬇️

scientific article published on November 1, 2003

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)

scientific article

Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry

scientific article published in September 2002

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice

scientific article published on 17 July 2017

Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes

scientific article published on January 2005

Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study

scientific article

Response to: DEA in consumer products is safe

scientific article published in January 2007

Second trimester folate status and preterm birth

scientific article published in December 2004

Sex and menopausal status influence human dietary requirements for the nutrient choline

scientific article

Spectral deconvolution for gas chromatography mass spectrometry-based metabolomics: current status and future perspectives

scientific article

Status of nutrition education in medical schools

scientific article

The Nutrigenetics and Nutrigenomics of the Dietary Requirement for Choline ⬇️

scientific article published on January 1, 2012

The Role of Dietary Supplements during Cancer Therapy ⬇️

scientific article published on November 1, 2003

The association between betaine and choline intakes and the plasma concentrations of homocysteine in women

scientific article published on October 2007

The betaine and choline content of a whole wheat flour compared to other mill streams

scientific article published on January 2007

The betaine content of sweat from adolescent females

scientific article

The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic

scientific article

The evolution of Nutrition in Medicine, a computer-assisted nutrition curriculum

scientific article published on April 2006

The fetal origins of memory: the role of dietary choline in optimal brain development

scientific article

The supply of choline is important for fetal progenitor cells ⬇️

scientific article published on June 12, 2011

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease

scientific article

Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers

scientific article published on October 2009

Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective disorder being treated with lithuim, haloperidol and benztropine: a case report

scientific article

Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study

scientific article published on 13 July 2007

What Choline Metabolism Can Tell Us About the Underlying Mechanisms of Fetal Alcohol Spectrum Disorders ⬇️

scientific article published on January 25, 2011

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