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List of works by Amy Hauck Newman

2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts

scientific article published on 24 September 2019

A Diastereospecific Synthesis of 2-Methyl-5β-phenyl-5α-carbethoxy-2- azabicyclo[2.2.1]heptane: A Ring-Constrained Analogue of Meperidine ⬇️

scientific article published on 01 February 1998

A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter

scientific article published on 22 August 2019

A Novel PKC Inhibitor Shows Promise for Amphetamine Use Disorders

scientific article

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter

scientific article

A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats

scientific article published on 14 April 2008

Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors

scientific article

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR

scientific article

Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling

scientific article

Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors

scientific article published on 19 February 2009

Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs

scientific article

Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan

scientific article published in January 2003

Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons.

scientific article published on 15 June 2017

Behavioral effects of rimcazole analogues alone and in combination with cocaine

scientific article published in May 2003

Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse

scientific article

Cocaine self-administration in dopamine D₃ receptor knockout mice

scientific article published on 6 August 2012

Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity

scientific article

Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors

scientific article

Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics

scientific article published on 01 November 2018

Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site

scientific article

Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

scientific article

Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors

scientific article

Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.

scientific article

Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists

scientific article published on 4 January 2007

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ⬇️

scientific article published on December 28, 2010

Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys

scientific article (publication date: May 2015)

Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.

scientific article

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists

scientific article

Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens

scientific article

Dopamine D Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy

scientific article published on 01 April 2019

Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia

scientific article

Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein

scientific article published in November 2004

Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys

scientific article

Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents

scientific article

Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways

scientific article

Dopamine D3 receptors mediate the discriminative stimulus effects of quinpirole in free-feeding rats

scientific article

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

scientific article published on 27 November 2018

Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior

scientific article

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

scientific article

Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability

scientific article

Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression

scientific article

Drinking sucrose enhances quinpirole-induced yawning in rats ⬇️

scientific article published on December 1, 2011

Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol

scientific article

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents

scientific article

Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell

scientific article published on 31 January 2019

Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine

scientific article

Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands

scientific article published on 30 January 2004

Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm

scientific article published on 21 October 2014

Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats

scientific article

Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats ⬇️

scientific article published on June 24, 2011

Effects of selective dopaminergic compounds on a delay-discounting task ⬇️

scientific article published on August 1, 2011

Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats

scientific article published on 18 February 2018

Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and dis

scientific article published in February 2007

Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter

scientific article published in May 2002

Erratum: Corrigendum: A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

scientific article published in Nature Communications

Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats ⬇️

scientific article published on September 17, 2010

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats

scientific article published on 05 February 2009

Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques

scientific article published on 9 September 2003

Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats

scientific article published on 13 September 2013

Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects

scientific article published on 27 February 2008

Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys

scientific article

Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents

scientific article published on 2 August 2007

Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

scientific article published on 31 March 2015

Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists

scientific article published on 14 July 2010

Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole ⬇️

scientific article published on 05 May 2011

Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs

scientific article

Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D3 Receptor Antagonists and Partial Agonists

scientific article published on 15 October 2019

Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists

scientific article published on 29 November 2014

Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis

scientific article published in July 2006

Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites

scientific article published on 23 January 2008

Medication discovery for addiction: translating the dopamine D3 receptor hypothesis

scientific article published on 03 July 2012

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators as Novel Tools for in Vivo Investigation ⬇️

scientific article published on May 22, 2012

Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions

scientific article published on 27 April 2020

Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists

scientific article published on 15 July 2011

Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia

scientific article published on 09 January 2019

N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity

scientific article

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

scientific article

N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists

scientific article

N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands

scientific article

N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects

scientific article

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites

scientific article published on 22 December 2015

Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram

scientific article published on 8 July 2015

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism

scientific article published on 16 March 2017

Novel and Potent Dopamine D Receptor Go-Protein Biased Agonists

article

Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter.

scientific article published on December 2004

Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor

scientific article

PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats

scientific article published on 08 February 2010

Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling

scientific article published on 7 April 2005

Place conditioning and locomotor effects of N-substituted, 4',4''-difluorobenztropine analogs in rats

scientific article published on 2 March 2005

Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole

scientific article

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

scientific article

R-modafinil attenuates nicotine-taking and nicotine-seeking behavior in alcohol-preferring rats

scientific article published on 23 January 2015

Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies

scientific article published in May 2005

Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue

scientific article

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

scientific article published on 10 April 2018

Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change

scientific article published on 24 April 2013

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

scientific article

Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs

scientific article published on 13 July 2005

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

scientific article published in December 2005

Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens

scientific article published on 16 March 2019

Social rank, neophobia and observational learning in black-capped chickadees

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter ⬇️

scientific article published on September 24, 2012

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

scientific article

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

scientific article

Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues

scientific article

Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

scientific article published on 14 November 2019

Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter

scientific article

Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation

scientific article

Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation

scientific article

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonist

scientific article

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol

scientific article

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5

scientific article

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

scientific article published on 10 February 2017

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors

scientific article

Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives

scientific article

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

scientific article published on 24 November 2017

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter

scientific article

The N terminus of monoamine transporters is a lever required for the action of amphetamines

scientific article

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

scientific article

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists

scientific article published on 01 July 2019

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

scientific article

The binding sites for cocaine and dopamine in the dopamine transporter overlap

scientific article

The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats

scientific article

The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys

scientific article published on 10 June 2009

The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access

scientific article

The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor

scientific article

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

scientific article published on 08 February 2008

The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders

scientific article

The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse

scientific article published on December 2008

The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats

scientific article

The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

scientific article published on 6 September 2017

The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats

scientific article

The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration

scientific article published on 14 September 2012

The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice

scientific article published on 22 August 2016

Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter

scientific article

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

scientific article

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

scientific article published on 11 March 2019

Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse

scientific article published on 26 September 2006

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

scientific article published on 3 November 2005

Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs

scientific article published on May 2009

Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D3 receptors

scientific article published on 17 October 2017

[--C]-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1-indole-2-carboxamide ([C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey

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