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List of works by Leif Bertilsson

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians

scientific article

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

scientific article published on 6 November 2008

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

scientific article

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants

scientific article published on January 2006

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

scientific article published on 10 March 2009

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects

scientific article

Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo

CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking

article by Margareta Ramsjö et al published 25 May 2010 in European Journal of Clinical Pharmacology

CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

scientific article published in May 2007

CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction

scientific article published on 22 July 2008

CYP2D6, serotonin and suicide

scientific article published on July 2010

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

scientific article

Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients

scientific article published on 9 February 2010

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin

scientific article published on 14 May 2013

Comparison ofN-Acetyltransferase-2 Enzyme Genotype-Phenotype and Xanthine Oxidase Enzyme Activity Between Swedes and Koreans

Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans

article

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol

scientific article published on 19 January 2011

Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.

scientific article

Differences in CYP2C9 Genotype and Enzyme Activity Between Swedes and Koreans of Relevance for Personalized Medicine: Role of Ethnicity, Genotype, Smoking, Age, and Sex

scholarly article by Fazleen H.M. Hatta published in June 2015

Dose of proton pump inhibitors and the CYP2C19 genotype

scientific article published in July 2004

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin

article by Mikko Niemi et al published August 2006 in Pharmacogenetics and Genomics

Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity ⬇️

scientific article published on December 1, 2003

Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden

scientific article published in July 2002

Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.

scientific article published on 20 April 2010

Genetic and Clinical Factors Affecting Plasma Clozapine Concentration

scientific article published on 19 February 2015

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

scientific article

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

scientific article

High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population

scientific article

Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations

scientific article

Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers

scientific article published on 20 February 2008

Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes

article by Natasa Djordjevic et al published 22 December 2007 in European Journal of Clinical Pharmacology

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients.

scientific article

Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease

scientific article published on 26 November 2009

Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI).

scientific article published on 29 November 2007

Interferon-beta treatment in patients with multiple sclerosis does not alter CYP2C19 or CYP2D6 activity

scientific article published in September 2003

Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study

scientific article published on April 2015

Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects

scientific article published on 25 July 2008

Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients

scientific article published on 29 April 2016

Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype

scientific article published in Scientific Reports

Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).

scientific article published in March 2002

MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs

scientific article published on 14 February 2009

Metabolism and elimination of quinine in healthy volunteers

scientific article published on 12 August 2003

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation

scientific article published on 9 December 2011

Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes

scientific article published in October 2003

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs

scientific article

Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression

scientific article published on 14 February 2007

N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians.

scientific article

Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes

scientific article published in September 2004

Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines

scientific article published in February 2006

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance

scientific article

Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles

scientific article

Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives

Population Pharmacokinetic Model Linking Plasma and Peripheral Blood Mononuclear Cell Concentrations of Efavirenz and Its Metabolite, 8-Hydroxy-Efavirenz, in HIV Patients

scientific article published on 30 May 2017

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study

scientific article published on August 2016

Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

scientific article published on 11 March 2003

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin

scientific article published on 11 February 2014

S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians

scientific article published in December 1996

Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes

scientific article published in February 2012

Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy

scientific article published in December 2004

The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity

scientific article published in January 2002

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

scientific article

Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy

scientific article published on 12 February 2008

Voriconazole and fluconazole increase the exposure to oral diazepam

scientific article

Xanthine oxidase activity is influenced by environmental factors in Ethiopians

scientific article published on 21 August 2003

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