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List of works by Cheng-Xin Gong

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse) ⬇️

scientific article published on November 14, 2012

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease ⬇️

scientific article published on January 1, 2011

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays ⬇️

scientific article published on January 1, 2003

Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles

scientific article published on 10 January 2014

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

scientific article

Anesthesia induces phosphorylation of tau

scientific article

Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice

scientific article published on 02 April 2020

Anesthetics and Tau Protein: Animal Model Studies ⬇️

scientific article published on January 1, 2010

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

scientific article published in January 2005

Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease ⬇️

scientific article published on December 7, 2012

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

scientific article published on 31 July 2009

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.

scientific article published on 7 March 2017

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

scientific article published on 22 January 2013

Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain

scientific article published in January 2018

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

scientific article published on 10 February 2014

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting

scientific article

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

scientific article published in October 2005

Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

scientific article published on 7 January 2016

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

scientific article

Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion

scientific article published on 14 September 2013

Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.

scientific article published on 4 June 2012

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease

scientific article

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

scientific article published on April 2008

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

scientific article

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes ⬇️

scientific article published on May 19, 2011

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

scientific journal article

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

scientific article published on 15 November 2004

Deregulation of brain insulin signaling in Alzheimer's disease

scientific article published on 20 March 2014

Deregulation of sphingolipid metabolism in Alzheimer's disease

scientific article

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain ⬇️

scientific article published on August 22, 2012

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases ⬇️

scientific article published on 13 January 2009

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

scientific article published on April 19, 2012

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells ⬇️

scientific article published on June 8, 2012

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

scientific article

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Enhances Tau Expression ⬇️

scientific article published on January 1, 2013

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion ⬇️

scientific article published on July 5, 2012

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

scientific article

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

scientific article published on 08 October 2009

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

scientific article

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

scientific article

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

scientific article

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

scientific article published on 27 September 2017

From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration

scientific article

GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner

scientific article published on 9 October 2015

Hyperphosphorylation-Induced Tau Oligomers ⬇️

scientific article published on August 15, 2013

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

scientific article

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

scientific article

Inhibition of Glycogen Synthase Kinase-3 Reverses Tau Hyperphosphorylation Induced by Pin1 Down-Regulation ⬇️

scientific article published on May 1, 2013

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

scientific article published in April 2003

Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT)

scientific article published on 10 July 2013

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

scientific article published on 13 August 2014

Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice

scientific article

Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes

scientific article

Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice

scientific article published on 16 February 2016

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

scientific article

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

scientific article published on 8 June 2014

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

scientific article (publication date: 23 October 2002)

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome

scientific article

Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit

scientific article published in January 2014

Mechanisms of tau-induced neurodegeneration

scientific article

Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

scientific article published on 03 January 2014

Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease

scientific article published on 16 March 2018

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain

scientific article published in January 2005

Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

scientific article published on 26 May 2020

O-GlcNAc cycling modulates neurodegeneration ⬇️

scientific article published on October 9, 2012

O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury

scientific article published on 6 September 2017

O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms

scientific article published on 7 February 2018

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

scientific article published on 3 February 2016

O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

scientific article

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

scientific article

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

scientific article published on 25 April 2016

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

scientific article published on September 2003

Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway

scientific article

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

scientific article published on 28 May 2008

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

scientific article

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

scientific article published in January 2010

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

scientific article published on 19 September 2014

Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau

Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion

scientific article published on 15 January 2018

Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

scientific article

Recent developments with tau-based drug discovery

scientific article published in March 2018

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

scientific article

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

scientific article

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

scientific article

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells

scientific article

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A ⬇️

scientific article published on April 5, 2011

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease

scientific article published on 6 February 2018

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

scientific article

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

scientific article

Splicing factor SC35 promotes tau expression through stabilization of its mRNA ⬇️

scientific article published on February 17, 2011

Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice

TDP-43 suppresses tau expression via promoting its mRNA instability

scientific article

Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

scientific article published on 13 August 2015

Targeting tau protein in Alzheimer's disease

scientific article published on May 2010

Tau and neurodegenerative disease: the story so far.

scientific article

Tau exon 10 alternative splicing and tauopathies

scientific article published on 10 July 2008

Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice

scientific article published on 31 January 2018

Tau passive immunization inhibits not only tau but also Aβ pathology

scientific article published on 10 January 2017

Tau pathology in Alzheimer disease and other tauopathies

scientific article

The role of DYRK1A in neurodegenerative diseases ⬇️

scientific article published on December 13, 2010

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

scientific article published on 12 August 2008

Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies

scientific article published on 9 May 2017

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.

scientific article published on 27 April 2015

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

scientific article

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

scientific article

Truncation of tau selectively facilitates its pathological activities

scientific article published on 31 July 2020

Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease

scientific article published on 18 October 2017

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

scientific article published on 25 May 2002

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