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List of works by Xinyong Liu

"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets

scientific article published on August 2014

"Old friends in new guise": exploiting privileged structures for scaffold re-evolution/refining

scientific article published on January 2014

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation

scientific article

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 18 September 2008

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries

scientific article published on 8 September 2017

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

scientific article

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

scientific article published on 30 June 2012

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors

scientific article

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

scientific article

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach

scientific article published on 21 July 2016

Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach

article

Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors

scientific article

Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm

scientific article published on January 2010

Capsid (CA) protein as a novel drug target: recent progress in the research of HIV-1 CA inhibitors

scientific article published on April 2009

Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport

scientific article published on January 2009

Conformational restriction: an effective tactic in 'follow-on'-based drug discovery

scientific article published on May 2014

Cosalane and its analogues: a unique class of anti-HIV agents

scientific article published on September 2010

Current insights into anti-HIV drug discovery and development: A review of recent patent literature (2014-2017).

scientific article published on 7 February 2018

Design strategies of novel NNRTIs to overcome drug resistance

scientific article published on January 2009

Design, Synthesis and Anti-HIV-1 Evaluation of Novel Arylazolylthioacetanilides as Potent NNRTIS

article

Design, Synthesis, and Acetylcholinesterase Inhibition Assay of Novel 9-(1-(Substituted-benzyl)piperidin-4-yl)-2-chloro-9H-purin-6-amine Derivatives

scholarly article in Journal of Chemistry, 2013

Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

scientific article

Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents

scientific article published on 8 September 2015

Design, Synthesis, and Biological Evaluation of Novel 4-Aminopiperidinyl-linked 3,5-Disubstituted-1,2,6-thiadiazine-1,1-dione Derivatives as HIV-1 NNRTIs

scientific article

Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents

scientific article published on 15 December 2014

Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

scientific article published on 19 August 2016

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization

scientific article published on 17 September 2014

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs

scientific article

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket

scientific article published on 22 December 2015

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs

scientific article published on October 2013

Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs

scientific article published on 14 September 2013

Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction

scientific article published on January 2014

Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket

scientific article

Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors

scientific article published on 25 July 2016

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs

scientific article published on 6 November 2013

Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors

scientific article published on 24 April 2017

Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

scientific article published on 10 September 2013

Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

scientific article published on 09 April 2016

Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors

scientific article published on 21 April 2012

Designed multiple ligands: an emerging anti-HIV drug discovery paradigm

scientific article published on January 2009

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate

scientific article published on 27 May 2014

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays

scientific article published on 6 February 2014

Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors

scientific article published in February 2018

Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold

scientific article published on 06 March 2015

Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase

scientific article published on 8 October 2014

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site

scientific article published on 27 February 2018

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

scientific article published on 19 October 2017

Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries

scientific article published on 24 August 2015

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

scientific article published on 25 August 2011

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach

scientific article published on 19 February 2014

Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities

scientific article

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

scientific article

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays

scientific article

Discovery of novel anti-HIV agents via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach

scientific article published on 11 July 2016

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach

scientific article published on 13 April 2014

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

scientific article

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement

scientific article published on 05 October 2016

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

article

Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 3 May 2013

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif

scientific article published on 26 July 2015

Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.

scientific article

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

scientific article published on 21 February 2017

Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities

scientific article published on 15 September 2015

Functional roles of azoles motif in anti-HIV agents

scientific article published on January 2011

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery

scientific article published in March 2018

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach

scientific article published on 30 July 2014

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches

scientific article

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines

scientific article published on 16 February 2015

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

scientific article published on March 2014

HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design

scientific article published on 26 April 2011

Heterocycle-thioacetic acid motif: a privileged molecular scaffold with potent, broad-ranging pharmacological activities

scientific article published on January 2013

Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1.

scientific article

Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics

scientific article published on 12 January 2018

Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives

scientific article

Ligustrazine Derivatives. Part 6: Design, Synthesis and Evaluation of Novel Ligustrazinyl Acylguanidine Derivatives as Potential Cardiovascular Agents ⬇️

scientific article published on September 1, 2012

Ligustrazine derivatives. Part 5: Design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents ⬇️

scientific article published on September 29, 2011

Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016).

scientific article published on November 2016

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors

scientific article

Medicinal chemistry of small molecule CCR5 antagonists for blocking HIV-1 entry: a review of structural evolution

scientific article

Multivalent agents: a novel concept and preliminary practice in Anti-HIV drug discovery

scientific article published on February 2013

Naturally occurring and synthetic bioactive molecules as novel non-nucleoside HBV inhibitors

scientific article published on February 2010

New therapeutic approaches targeted at the late stages of the HIV-1 replication cycle

scientific article

Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies

scientific article

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 - 2010).

scientific article published on 04 April 2011

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011-2014).

scientific article

Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1.

scientific article

Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2).

scientific article

Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419.

scientific article published on 28 September 2015

Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1.

scientific article published on 9 March 2017

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on November 2013

Pharmacokinetics and metabolism of Chf197, a ligustrazine derivative, in rats

scientific article published on 3 August 2015

Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related Bridgehead Nitrogen Heterocycles in Medicinal Chemistry ⬇️

scientific article published on January 1, 2013

Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182.

scientific article published on 11 July 2016

Recent Advances in the DABOs Family as Potent HIV-1 non-Nucleoside Reverse Transcriptase Inhibitors ⬇️

scientific article published on January 1, 2011

Recent Advances of Diaryl Ether Family as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors ⬇️

scientific article published on January 1, 2013

Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview

scientific article published on January 2015

Recent advances in DAPYs and related analogues as HIV-1 NNRTIs

scientific article published on January 2011

Recent advances in antiviral activity of benzo/heterothiadiazine dioxide derivatives

scientific article published on January 2008

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms (Part II): 2009-2013 update

scientific article published on January 2014

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms: 2006-2008 update

scientific article published on January 2009

Recent advances in the research of 2,3-diaryl-1,3-thiazolidin-4-one derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on January 2012

Recent advances in the research of HIV-1 RNase H inhibitors

scientific article published on October 2008

Recent advances in the structure-based rational design of TNKSIs

scientific article

Recent progress in small molecule CCR5 antagonists as potential HIV-1 entry inhibitors

scientific article published on January 2012

Recent progress in the research of small molecule HIV-1 RNase H inhibitors

scientific article

Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives

scientific article published on 5 February 2018

Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies

scientific article

Regioselective synthesis of novel N2- and N4-substituted 7-methylpyrazolo[4,5-e][1,2,4]thiadiazines.

scientific article published in November 2006

Repurposing of HDAC inhibitors toward anti-hepatitis C virus drug discovery: teaching an old dog new tricks

scientific article published on August 2015

Retroviral restriction factors TRIM5α: therapeutic strategy to inhibit HIV-1 replication

scientific article published on January 2011

Review of small synthetic molecules targeting HBV capsid assembly

scientific article published on 19 May 2015

Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

article

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

scientific article published on 18 June 2015

Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket

scientific article published on 25 May 2016

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

scientific article published on 8 May 2017

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

scientific article

Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928).

scientific article

Sulfanyltriazole/tetrazoles: a promising class of HIV-1 NNRTIs

scientific article published on July 2009

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

article

Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors

scientific article

Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections

scientific article published on 20 January 2015

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Synthesis and anti-HIV activity evaluation of novel N′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides

article

Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives

scientific article published on 30 June 2014

Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).

scientific article published on 10 October 2007

Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

scientific article published on 14 February 2011

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

scientific article published on 18 July 2009

Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

scientific article published on 24 September 2009

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 23 May 2011

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs

scientific article published on 9 January 2013

Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs

scientific article published on 22 August 2007

Synthesis of the novel liqustrazine derivatives and Their protective effect on injured vascular endothelial cell damaged by hydrogen peroxide

scientific article published on July 2003

Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates

scientific article

Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3'-azido-3'-deoxythymidine (AZT, Zidovudine).

scientific article

TSG101: a novel anti-HIV-1 drug target

scientific article published on January 2010

Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice

scientific article published on 22 December 2016

Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats.

scientific article

The Development of HEPT-Type HIV Non-Nucleoside Reverse Transcriptase Inhibitors and Its Implications for DABO Family ⬇️

scientific article published on January 1, 2012

The development of an effective synthetic route of lesinurad (RDEA594).

scientific article published on 5 September 2017

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2

scholarly article by Xueyi Lu published in May 2018

Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges

scientific article published on 13 January 2017

synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors

scientific article published on 20 February 2012

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