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List of works by Ruth Tal-Singer

A comparison of COPD patients with and without ACOS in the ECLIPSE study

scientific article published on 17 March 2016

A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease

scientific article

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

scientific article published on 11 November 2011

A novel endpoint for exacerbations in asthma to accelerate clinical development: a post-hoc analysis of randomised controlled trials

scientific article published on 02 June 2017

A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients

scientific article published on 30 October 2009

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease

scientific article published in September 2016

Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort

scientific article

An oral inhibitor of p38 MAP kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease.

scientific article

Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity

scientific article published on 12 January 2017

Baseline Severity as Predictor of Change in St George's Respiratory Questionnaire Scores in Trials of Long-acting Bronchodilators with COPD Patients

scientific article published on 21 March 2017

Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease

scientific article published on 28 June 2012

Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease

article

COPD association and repeatability of blood biomarkers in the ECLIPSE cohort ⬇️

scientific article published on November 4, 2011

COPD subtypes identified by network-based clustering of blood gene expression

scientific article published on 7 January 2016

Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes?

article

Changes in Forced Expiratory Volume in 1 Second over Time in COPD ⬇️

scientific article published on September 26, 2011

Characterisation of COPD heterogeneity in the ECLIPSE cohort ⬇️

scientific article published on September 10, 2010

Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort

scientific article

Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD.

scientific article published on 23 March 2016

Circulating soluble receptor for advanced glycation end products (sRAGE) as a biomarker of emphysema and the RAGE axis in the lung

scientific article published on July 2015

Clinical and prognostic heterogeneity of C and D GOLD groups

scientific article published in July 2015

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease

scientific article

Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort

scientific article published on 19 June 2013

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study

scientific article published on 08 January 2014

Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality.

scientific article published on 28 January 2014

Correlation Between Emphysema and Lung Function in Healthy Smokers and Smokers With COPD.

scientific article published on 19 May 2015

Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2.

scientific article published on 13 June 2017

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study

scientific article

Determinants of poor 6-min walking distance in patients with COPD: The ECLIPSE cohort

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis

Effect of inhaled corticosteroids on blood eosinophil count in steroid-naïve patients with COPD.

scientific article

Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD

article

Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype

scientific article published on 7 February 2018

Eosinophilic inflammation in COPD: prevalence and clinical characteristics

scientific article published on 16 October 2014

Evaluating the role of inflammation in chronic airways disease: the ERICA study

scientific article

Evaluation of exhaled breath condensate pH as a biomarker for COPD

article

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations

scholarly article published 26 June 2018

Fibrinogen, COPD and mortality in a nationally representative U.S. cohort

scientific article published on 11 April 2012

Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts

scientific article published on 7 March 2012

Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers

scientific article published on June 2008

Functional capacity, health status, and inflammatory biomarker profile in a cohort of patients with chronic obstructive pulmonary disease

scientific article

Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo-controlled clinical trial

scientific article published on 9 December 2014

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci

scientific article published on 14 October 2014

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

scientific article

Genetics of sputum gene expression in chronic obstructive pulmonary disease

scientific article (publication date: 2011)

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease

scientific article

Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (Copd); implications for stratified medicine?

scientific article

Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis

scientific article published on March 2015

Identifying Physical Activity Profiles in COPD Patients Using Topic Models

scientific article published on 12 May 2015

Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers.

scientific article published on 24 March 2011

Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease

article

Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: two randomised studies

scientific article published on 28 December 2012

It's more than low BMI: prevalence of cachexia and associated mortality in COPD

scholarly article by Merry-Lynn N McDonald et al published 22 May 2019 in Respiratory Research

Lessons from ECLIPSE: a review of COPD biomarkers

scientific article published on 05 December 2013

Long-term Course of Depression Trajectories in Patients With COPD: A 3-Year Follow-up Analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Cohort

scientific article published on 5 January 2016

Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years

scientific article published on 10 August 2017

Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

scientific article published on 31 January 2018

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis

scientific article published on 9 July 2015

Metabolic profiling detects biomarkers of protein degradation in COPD patients

article

Microfibrillar-associated protein 4: A potential biomarker of chronic obstructive pulmonary disease

scientific article (publication date: September 2014)

More than just innate immunity: comparative analysis ofChlamydophila pneumoniaeandChlamydia trachomatiseffects on host-cell gene regulation ⬇️

scientific article published on November 1, 2003

Multiple biomarkers predict disease severity, progression and mortality in COPD.

scientific article

Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema

scientific article published on 06 January 2016

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus

scientific article

One-year change in health status and subsequent outcomes in COPD.

scientific article published on 17 March 2015

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype ⬇️

scientific article published on May 18, 2012

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

scientific article

Plasma Fibrinogen Qualification as a Drug Development Tool in Chronic Obstructive Pulmonary Disease. Perspective of the Chronic Obstructive Pulmonary Disease Biomarker Qualification Consortium

scientific article

Plasma Fibrinogen as a Biomarker for Mortality and Hospitalized Exacerbations in People with COPD.

scientific article

Plasma microfibrillar-associated protein 4 is not prognostic of emphysema progression but is associated with cardiovascular disease history and mortality in COPD patients

scholarly article by Sofie Lock Johansson et al published April 2019 in ERJ open research

Predicting Outcomes from 6-Minute Walk Distance in Chronic Obstructive Pulmonary Disease ⬇️

scientific article published on July 21, 2011

Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study

scientific article

Prospects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational review

scientific article published on 05 May 2012

Quantification of Lung PET Images: Challenges and Opportunities

scientific article published on 12 January 2017

Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD

scholarly article by Russell Bowler et al published 2019 in BMJ open respiratory research

Reply: minimal or maximal clinically important difference: using death to define MCID.

scientific article

Respiratory system impedance with impulse oscillometry in healthy and COPD subjects: ECLIPSE baseline results ⬇️

scientific article published on April 11, 2011

Responder Analyses for Treatment Effects in COPD Using the St George's Respiratory Questionnaire

scientific article published on 02 March 2017

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

scientific article

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

scientific article

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

scientific article

Sarcopenic Obesity, Functional Outcomes, and Systemic Inflammation in Patients With Chronic Obstructive Pulmonary Disease

scientific article published on 5 May 2016

Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease

scientific article

Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team

scientific article published in May 2014

Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization

scientific article published on 21 December 2012

Socioeconomic Status as a Determinant of Health Status Treatment Response in COPD Trials

scientific article published on April 2017

Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study

scientific article

St George's Respiratory Questionnaire Score Predicts Outcomes in Patients with COPD: Analysis of Individual Patient Data in the COPD Biomarkers Qualification Consortium Database

scientific article

Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease ⬇️

scientific article published on September 16, 2010

Systemic Markers of Adaptive and Innate Immunity are Associated with COPD Severity and Spirometric Disease Progression

scientific article published on 5 December 2017

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease

scientific article published in October 2013

Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

article

The 6-Minute-Walk Distance Test as a Chronic Obstructive Pulmonary Disease Stratification Tool. Insights from the COPD Biomarker Qualification Consortium

scientific article published on 22 June 2016

The COPD Biomarker Qualification Consortium (CBQC).

scientific article published on June 2013

The COPD Biomarkers Qualification Consortium Database: Baseline Characteristics of the St George's Respiratory Questionnaire Dataset

scientific article published on 13 March 2017

The St. George's Respiratory Questionnaire Appendix to the Food and Drug Administration Draft Guidance on COPD: Why a Small Step Forward Is So Important

scientific article

The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial.

scientific article

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects

scientific article published on 20 June 2015

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

scientific article published in February 2013

The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD.

scientific article published on February 2008

Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort

article published in 2019

Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development

scientific article published in May 2005

Variants in FAM13A are associated with chronic obstructive pulmonary disease

scientific article

p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease

scientific article published on 12 March 2012

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