List of works by Timothy C Wang

17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice

scientific article

A CRISPR screen identifies a pathway required for paraquat-induced cell death

scientific article published on 23 October 2017

A DNA hypomethylating drug alters the tumor microenvironment and improves the effectiveness of immune checkpoint inhibitors in a mouse model of pancreatic cancer

scientific article published on 14 August 2020

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

scientific article (publication date: 8 September 2016)

A distinctive set of genes is upregulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis

scientific article published on 13 November 2006

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

scientific article

A unifying model for mTORC1-mediated regulation of mRNA translation.

scientific article

AGA Institute Future Trends Committee report: the future of gastroenterology training programs in the United States.

scientific article

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

scientific article published on August 2016

Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice

scientific journal article

Aggravated myocardial infarction-induced cardiac remodeling and heart failure in histamine-deficient mice.

scientific article published on 08 March 2017

Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung.

scientific article published in November 2006

Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy.

scientific article published on 23 November 2005

An Alternative to MOC?

scientific article published on 19 August 2015

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

scientific article published in July 2015

Analysis of transplanted bone marrow-derived cells in chronic pancreatitis.

scientific article

BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice

scientific article published on 15 November 2018

Barrett esophagus: what a mouse model can teach us about human disease

scientific article published on 24 October 2012

Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.

scientific article published on January 2012

Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop

scientific article published on 16 October 2020

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

scientific article published in Nature Communications

CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

scientific article published on 04 March 2019

CXCR4 is a potential target for diagnostic PET/CT imaging in Barrett's dysplasia and esophageal adenocarcinoma.

scientific article published on 5 December 2017

CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development.

scientific article published on 10 November 2017

Cancer. Bacteria deliver a genotoxic hit

scientific article published on 01 October 2012

Challenges of NIH funding for young investigators: how the AGA is filling the gap via the AGA research foundation.

scientific article published on June 2014

Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells.

scientific article

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

scientific article published on 05 September 2018

Colon cancer: an update and future directions.

scientific article published on 10 March 2010

Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.

scientific article published on 26 October 2011

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

scientific article

Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

scientific article published on 2 September 2015

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

scientific article published on 6 July 2017

Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy

scientific article published on 04 February 2019

Editorial

scientific article published on 01 July 2008

Epithelial Dclk1+ cells are not neural crest derived

scientific article published on 21 October 2016

Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice

scientific article published on 01 July 2018

Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia.

scientific article

Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

scientific article published on 13 January 2012

Functional implication of Dclk1 and Dclk1-expressing cells in cancer.

scientific article

Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1

scientific article published on 04 March 2019

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

scientific article published on 26 November 2019

Gastric cancer originating from bone marrow-derived cells

scientific article published on 01 November 2004

Gastric cancer stem cells

scientific article published on June 2008

Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis

scientific article published on 28 June 2013

Gastrin and cancer: a review.

scientific article

Gastrin and upper GI cancers

scientific article

Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice

scientific article published on July 2009

Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.

scientific article published on March 2007

Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism.

scientific article published on 5 February 2004

Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB.

scientific article published in September 2007

Gastrin-induced apoptosis contributes to carcinogenesis in the stomach

scientific article published on 07 August 2006

Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells.

scientific article published on April 2004

Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.

scientific article

Gastroenterologists as preventionists: how are we doing?

scientific article published on 01 August 2007

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

scientific article published on February 2017

Gene expression profiling in a mouse model of Helicobacter-induced gastric cancer.

scientific article published in March 2007

Genetic screens in human cells using the CRISPR-Cas9 system

scientific article (publication date: 3 January 2014)

Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines

scientific article published on 01 January 2019

Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.

scientific article published on 05 September 2013

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.

scientific article published on December 2008

Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma

scientific article published on 2 November 2016

Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production.

scientific article

Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.

scientific article published on 26 April 2007

Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice.

scientific article published on 17 November 2015

Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers.

scientific article

Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice.

scientific article published on December 2005

Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.

scientific article published on 25 April 2008

Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice

scientific article

Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.

scientific article published on 27 August 2010

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms

scientific article published on 21 November 2017

Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota

scientific article

High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.

scientific article

High-resolution genomic alterations in Barrett's metaplasia of patients who progress to esophageal dysplasia and adenocarcinoma

scientific article published on 02 May 2019

Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis.

scientific article

Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis

scientific article

Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas

scientific article published on 26 May 2015

Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway.

scientific article published on 23 May 2017

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

scientific article

How to Succeed in Academic Gastroenterology

scientific article

Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.

scientific article

Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.

scientific article published on 12 June 2009

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis.

scientific article published on 7 September 2007

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

scientific article published on 29 November 2012

IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis

scientific article

Identification and characterization of essential genes in the human genome.

scientific article

Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells.

scientific article published on 20 June 2008

Imaging of Secreted Extracellular Periostin, an Important Marker of Invasion in the Tumor Microenvironment in Esophageal Cancer.

scientific article published on 11 June 2015

Implications of the "Bad Luck" Explanation of Cancer Risk for the Field of Cancer Prevention

scientific article published on 14 July 2015

In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.

scientific article

In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice ⬇️

scientific article published on November 4, 2010

Increased expression of chemerin in squamous esophageal cancer myofibroblasts and role in recruitment of mesenchymal stromal cells

scientific article

Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling.

scientific article published on 11 January 2007

Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.

scientific article

Inflammation and cancer: IL-6 and STAT3 complete the link.

scientific article published on February 2009

Inflammation and stem cells in gastrointestinal carcinogenesis.

scientific article published on December 2008

Inflammation, atrophy, and gastric cancer

scientific article

Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.

scientific article

Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.

scientific article

Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression

scientific article published on 10 May 2020

Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium

scientific article published on 14 December 2018

Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice.

scientific article published on 4 May 2017

Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

scientific article published on June 2015

Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.

scientific article

Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis

scientific article published on 26 July 2018

Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens

scientific article

Long-lived intestinal tuft cells serve as colon cancer-initiating cells

scientific article

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.

scientific article published on 8 May 2017

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

scientific article published on 14 March 2016

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury.

scientific article published on 13 October 2016

Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches.

scientific article

Mature gastric chief cells are not required for the development of metaplasia.

scientific article published on 18 January 2018

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

scientific article

Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.

scientific article published on 03 October 2012

Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice

scientific article published on 24 July 2020

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?

scientific article published on 17 October 2009

Mouse models of gastric cancer.

scientific article published on 24 January 2013

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

scientific article

Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.

scientific article published on 7 December 2016

Nerves switch on angiogenic metabolism.

scientific article published in October 2017

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.

scientific article published on 4 February 2016

Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential

scientific article

Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?

scientific article published on April 2016

Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.

scientific article published on 22 October 2012

Origins of Metaplasia in the Esophagus: Is This a GE Junction Stem Cell Disease?

scientific article published on 01 August 2018

Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.

scientific article published on November 2008

P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice

scientific article published on 05 April 2012

Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas.

scientific article published on 15 December 2011

Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis

scientific article published on 11 January 2010

Prevention of gastric cancer with antibiotics: can it be done without eradicating Helicobacter pylori?

scientific article

Providing AID to p53 mutagenesis

scientific article published on 01 April 2007

Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

scientific article published on 08 January 2020

Randomized Controlled Trial of the Gastrin/CCK<sub>2</sub> Receptor Antagonist Netazepide in Patients with Barrett's Esophagus

scientific article published on 29 March 2021

Rapid gastrointestinal loss of Clostridial Clusters IV and XIVa in the ICU associates with an expansion of gut pathogens

scientific article published on 01 August 2018

Regulation of L-histidine decarboxylase and its role in carcinogenesis.

scientific article published on January 2006

Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.

scientific article

RhoA mutations identified in diffuse gastric cancer

scientific article published on July 2014

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

scientific article

Screening endoscopy finds high prevalence of Helicobacter pylori and intestinal metaplasia in Korean American with limited access to health care.

scientific article published on 26 April 2017

Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines

scientific article

Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

scientific article

Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.

scientific article

Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer.

scientific article published on 5 May 2010

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.

scientific article published on 4 December 2017

Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries.

scientific article

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors.

scientific article

Stromal fibroblasts in digestive cancer

scientific article

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

scientific article

Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment

scientific article published on 01 October 2005

Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

scientific article published in June 2005

Systematic identification of signaling pathways with potential to confer anticancer drug resistance.

scientific article

TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow

scientific article published on 16 October 2014

TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.

scientific article

Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA.

scientific article

Targeting liver cancer: first steps toward a miRacle?

scientific article published on December 2011

The APC and PreSAP trials: a post hoc noninferiority analysis using a comprehensive new measure for gastrointestinal tract injury in 2 randomized, double-blind studies comparing celecoxib and placebo

scientific article published on 02 March 2012

The C-terminus of rat L-histidine decarboxylase specifically inhibits enzymic activity and disrupts pyridoxal phosphate-dependent interactions with L-histidine substrate analogues

scientific article

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

scientific article published on 8 April 2015

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models.

scientific article

The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

scientific article published on 01 July 2018

The biological role of the low-affinity p75 neurotrophin receptor in esophageal squamous cell carcinoma.

scientific article published on September 2006

The evolution of the cancer niche during multistage carcinogenesis

scientific article published on 13 June 2013

The extracellular matrix in digestive cancer

scientific article published on 17 September 2010

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

scientific article published on 03 October 2013

The gastrointestinal tumor microenvironment

scientific article

The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation

scientific article published on 30 July 2014

The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy

scientific article

The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression

scientific article published on 7 April 2014

The rapid rise in gastroesophageal junction tumors: is inflammation of the gastric cardia the underwater iceberg?

scientific article published on 23 August 2013

Therapeutic potential of adenovirus-mediated TFF2-CTP-Flag peptide for treatment of colorectal cancer

scientific article published on 25 July 2018

Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity.

scientific article published on 7 September 2007

Topical application of acetic acid in cytoreduction of gastric cancer. A technical report using mouse model.

scientific article

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.

scientific article published on 13 February 2012

Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair

scientific article published on 7 September 2011

Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses

scientific journal article

Use of proton pump inhibitors and subsequent risk of celiac disease

scientific article published on 12 September 2013

Vagotomy and Gastric Tumorigenesis

scientific article published on 20 January 2016

What are the therapeutic advances in gastroenterology? opinions from world experts.

scientific article

XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.

scientific article

Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site.

scientific article published on 15 December 2005

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

scientific article published in December 2017

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

scientific article published on 01 November 2018

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