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List of works by Céline Brochot

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

scientific article published on 01 February 2011

A physiologically based toxicokinetic model for the zebrafish Danio rerio.

scientific article published on 11 December 2013

A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan.

scientific article published in February 2010

Analysis of real-time mixture cytotoxicity data following repeated exposure using BK/TD models.

scientific article

Assessing multimedia/multipathway exposures to inorganic arsenic at population and individual level using MERLIN-Expo

scientific article

BK/TD models for analyzing in vitro impedance data on cytotoxicity

scientific article

Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography-ion trap mass spectrometry.

scientific article published on 10 April 2014

Development of a physiologically based kinetic model for 99m-technetium-labelled carbon nanoparticles inhaled by humans

scientific article published in November 2009

Evaluation of antiangiogenic treatment effects on tumors' microcirculation by Bayesian physiological pharmacokinetic modeling and magnetic resonance imaging.

scientific article published on 23 May 2006

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips.

scientific article published on 25 July 2012

Improvement of HepG2/C3a cell functions in a microfluidic biochip ⬇️

scientific article published on March 11, 2011

In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes.

scientific article published on 9 March 2015

Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women.

scientific article published on 4 July 2012

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

scientific article published on 28 August 2012

Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system

article

Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water.

scientific article published on 2 April 2011

Lumping in pharmacokinetics.

scientific article

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.

scientific article published on 22 May 2012

Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.

scientific article published on 8 February 2012

Modelling ecological and human exposure to POPs in Venice lagoon - Part II: Quantitative uncertainty and sensitivity analysis in coupled exposure models

scientific article

Modelling ecological and human exposure to POPs in Venice lagoon. Part I - Application of MERLIN-Expo tool for integrated exposure assessment.

scientific article published on 10 May 2016

Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool

scientific article

Multimedia & PBPK modelling with MERLIN-Expo versus biomonitoring for assessing Pb exposure of pre-school children in a residential setting.

scientific article

PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats.

scientific article

Potential for MERLIN-Expo, an advanced tool for higher tier exposure assessment, within the EU chemical legislative frameworks.

scientific article published on 21 April 2016

Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models.

scientific article published on 4 December 2010

Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: a case study with acetaminophen.

scientific article

Quantifying heterogeneity in exposure-risk relationships using exhaled breath biomarkers for 1,3-butadiene exposures

scientific article

Toxicokinetic models and related tools in environmental risk assessment of chemicals.

scientific article

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