List of works by Markus Alexander Zeitlinger

"Iatrogenicity cascade": doing harm by treating harm?

scientific article published in January 2009

A FIM study to assess safety and exposure of inhaled single doses of AP301-A specific ENaC channel activator for the treatment of acute lung injury.

scientific article published on March 2014

A PET microdosing study with the P-glycoprotein inhibitor tariquidar

A Prediction Method for P-glycoprotein-Mediated Drug-Drug Interactions at the Human Blood-Brain Barrier From Blood Concentration-Time Profiles, Validated With PET Data.

scientific article

A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

scientific article published on 20 September 2018

A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil.

scientific article published on February 2011

A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of C- and C-labelled verapamil in healthy volunteers

A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain.

scientific article published on 11 February 2015

A pharmacodynamic evaluation of dexmedetomidine as an additive drug to ropivacaine for peripheral nerve blockade: A randomised, triple-blind, controlled study in volunteers.

scientific article published on 18 February 2015

A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung.

scientific article published in January 2007

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

scientific article published on 12 November 2009

A population pharmacokinetic model of intravenous telavancin in healthy individuals to assess tissue exposure

scientific article published on 06 May 2019

A randomised, two-period, cross-over, open-label study to evaluate the pharmacokinetic profiles of single doses of two different flurbiprofen 8.75-mg lozenges in healthy volunteers

scientific article published on 20 March 2012

Abscess penetration of cefpirome: concentrations and simulated pharmacokinetic profiles in pus

scientific article published on 23 March 2012

Absolute oral bioavailability and metabolic turnover of β-sitosterol in healthy subjects

scientific article published on 23 July 2012

Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease: A Randomized, Double-Blind, Placebo-Controlled Trial.

scientific article published on 12 May 2016

Advancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14–16, 2018; Vienna, Austria

article

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET.

scientific article published on 05 August 2009

An Open, Randomized, Single-Center, Crossover Pharmacokinetic Study of Meropenem after Intraperitoneal and Intravenous Administration in Patients Receiving Automated Peritoneal Dialysis

scientific article published on 22 February 2016

An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.

scientific article published on December 2013

Antimicrobial activity of antibiotics in urine under different physiological conditions.

scientific article

Antimicrobial activity of cefepime and rifampicin in cerebrospinal fluid in vitro

Antimicrobial activity of cefepime and rifampicin in cerebrospinal fluid in vitro.

scientific article published on 25 July 2008

Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study.

scientific article published on 11 February 2015

Assessing pharmacokinetics of different doses of fosfomycin in laboratory rats enables adequate exposure for pharmacodynamic models

scientific article

Assessing the influence of diurnal variations and selective Xa inhibition on whole blood aggregometry.

scientific article published on 7 July 2015

Assessment of P-Glycoprotein Transport Activity at the Human Blood-Retina Barrier with (R)-11C-Verapamil PET.

scientific article published on 13 October 2016

Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.

scientific article published on 16 December 2009

Cefazolin and linezolid penetration into sternal cancellous bone during coronary artery bypass grafting.

scientific article published on 18 December 2014

Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: homologous or heterologous booster response following two dose or single dose priming.

scientific article

Cerebral and Peripheral Metabolism to Predict Successful Reperfusion After Cardiac Arrest in Rats: A Microdialysis Study

scientific article

Cerebrospinal fluid impairs antimicrobial activity of fosfomycin in vitro.

scientific article published on 21 July 2009

Characterization of colistin tissue pharmacokinetics by microdialysis.

scientific article

Chloroquine enhances the antimycobacterial activity of isoniazid and pyrazinamide by reversing inflammation-induced macrophage efflux.

scientific article

Circulating tuberculostearic acid in tuberculosis patients.

scientific article

Clinical Determinants of Target Non-Attainment of Linezolid in Plasma and Interstitial Space Fluid: A Pooled Population Pharmacokinetic Analysis with Focus on Critically Ill Patients.

scientific article published on 17 October 2016

Clinical Pharmacokinetics and Pharmacodynamics of Telavancin Compared with the Other Glycopeptides

scientific article published on 13 January 2018

Clinical applications of levofloxacin for severe infections.

scientific article published in January 2004

Clinical pharmacokinetics of fosfomycin after continuous infusion compared with intermittent infusion: a randomized crossover study in healthy volunteers

scientific article published on 26 October 2020

Colistin Reduces LPS-Triggered Inflammation in a Human Sepsis Model In Vivo: A Randomized Controlled Trial.

scientific article

Colistin dampens fibrinolysis and endothelial activation during endotoxaemia. A randomised, double blind trial.

scientific article published on 10 August 2017

Comment on "Target-Controlled Continuous Infusion for Antibiotic Dosing: Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients"

scientific article published on 01 July 2019

Comment on: Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass

scientific article published on 01 September 2018

Compatibility of Meropenem with Different Commercial Peritoneal Dialysis Solutions.

scientific article published on 7 September 2016

Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions

scientific article published on 24 April 2019

Compatibility of fosfomycin with different commercial peritoneal dialysis solutions.

scientific article published on 6 July 2017

Compatibility of linezolid with commercial peritoneal dialysis solutions

scientific article published on 01 October 2018

Concentrations of cefuroxime in brain tissue of neurointensive care patients.

scientific article published on 4 December 2017

Concentrations of fosfomycin in the cerebrospinal fluid of neurointensive care patients with ventriculostomy-associated ventriculitis.

scientific article published on 31 March 2004

Corrigendum to 'Chloroquine enhances the antimycobacterial activity of isoniazid and pyrazinamide by reversing inflammation-induced macrophage efflux' [The International Journal of Antimicrobial Agents 50/1 (2017) 55-62].

scientific article published on 14 November 2017

Cutaneous innervation of the hand: clinical testing in volunteers shows high intra- and inter-individual variability

scientific article published on 24 November 2017

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

scientific article published in May 2010

Daptomycin elimination by CVVH in vitro: evaluation of factors influencing sieving and membrane adsorption.

scientific article published in March 2009

Decreased protein binding of moxifloxacin in patients with sepsis?

scientific article published on 3 February 2017

Determination of total and free ceftolozane and tazobactam in human plasma and interstitial fluid by HPLC-UV

scientific article published on 24 September 2018

Development of a high-performance liquid chromatography method for the determination of caspofungin with amperometric detection and its application to in vitro microdialysis experiments

scientific article published on 19 June 2006

Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.

scientific article published on 25 August 2014

Dexamethasone as an adjuvant for peripheral nerve blockade: a randomised, triple-blinded crossover study in volunteers

scientific article published on 31 January 2019

Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study.

scientific article

Differential in vivo activation of monocyte subsets during low-grade inflammation through experimental endotoxemia in humans.

scientific article published on 22 July 2016

Dislocation rates of perineural catheters: a volunteer study.

scientific article published on 7 June 2013

Does circumferential spread of local anaesthetic improve the success of peripheral nerve block?

scientific article published on 25 February 2014

Does pulmonary surfactant generally affect antimicrobial activity?

scientific article published on 17 September 2012

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[11C]verapamil PET.

scientific article

Early immunomodulatory effects of linezolid in a human whole blood endotoxin model.

scientific article published in July 2010

Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11 C]verapamil in elderly vs. young subjects.

scientific article published on 12 April 2017

Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

scientific article published on 14 September 2018

Effect of cardiopulmonary bypass on regional antibiotic penetration into lung tissue.

scientific article published on 15 April 2013

Effective local anaesthetic volumes for sciatic nerve blockade: a clinical evaluation of the ED99.

scientific article

Effective treatment of a peripheral T-cell lymphoma/lymphoepitheloid cell variant (Lennert's lymphoma) refractory to chemotherapy with the CD-52 antibody alemtuzumab.

scientific article published in May 2005

Elimination of Doripenem during Dialysis and Pharmacokinetic Evaluation of Posthemodialysis Dosing for Patients Undergoing Intermittent Renal Replacement Therapy.

scientific article published on 12 March 2018

Enhanced activity of linezolid against Staphylococcus aureus in cerebrospinal fluid

scientific article published on 16 December 2011

Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans.

scientific article

Extended infusion-putting the benefit into context

scientific article published on 21 March 2018

Feasibility and pharmacokinetics of caudal blockade in children and adolescents with 30-50 kg of body weight

scientific article published on 11 July 2016

Feasibility of microdialysis for determination of protein binding and target site pharmacokinetics of colistin in vivo

scientific article published on 9 December 2014

Gewebepenetration von Antibiotika

scientific article published on 02 April 2014

Good penetration of moxifloxacin into human abscesses

scientific article published on 03 August 2012

Heterogeneous penetration of cefpirome and moxifloxacin into abscesses after simultaneous administration in humans.

scientific article

High voriconazole target-site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long-term microdialysis

scientific article published on 04 February 2019

Human Bile Reduces Antimicrobial Activity of Selected Antibiotics against Enterococcus faecalis and Escherichia coli In Vitro

scientific article published on 30 May 2017

Immunomodulatory effects of fosfomycin in experimental human endotoxemia.

scientific article published on 12 March 2007

Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans

scientific article published on 10 January 2019

Impact of different pathophysiological conditions on antimicrobial activity of glycopeptides in vitro

scientific article published on 27 September 2018

Impact of erythrocytes on bacterial growth and antimicrobial activity of selected antibiotics

scientific article published on 28 January 2019

Impact of pH on activity of trimethoprim, fosfomycin, amikacin, colistin and ertapenem in human urine.

scientific article published on 28 September 2012

Impact of pH on bacterial growth and activity of recent fluoroquinolones in pooled urine

scientific article published on 01 February 2011

In vitro activity of voriconazole and amphotericin B against Candida albicans, Candida krusei, and Cryptococcus neoformans in human cerebrospinal fluid

scientific article published on 06 February 2019

In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET.

scientific article published on 4 September 2004

In vivo P-glycoprotein function before and after epilepsy surgery.

scientific article

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin Against Escherichia Coli.

scientific article published on 28 September 2016

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

scientific article published on 22 September 2017

Influence of different peritoneal dialysis fluids on the in vitro activity of fosfomycin against Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa.

scientific article published on 15 March 2018

Internal mammary artery harvesting influences antibiotic penetration into presternal tissue

scientific article published on 22 February 2013

Intra-cystic drug concentration of albendazole sulphoxide in patients with Echinococcus granulosus cysts.

scientific article

Intravenous Fluid Challenge Decreases Intracellular Volume: A Bioimpedance Spectroscopy-Based Crossover Study in Healthy Volunteers.

scientific article published on 29 August 2017

Iontophoresis driven concentrations of topically administered diclofenac in skeletal muscle and blood of healthy subjects.

scientific article

Ketolides--the modern relatives of macrolides : the pharmacokinetic perspective.

scientific article published on January 2009

Lack of dermal penetration of topically applied gentamicin as pharmacokinetic evidence indicating insufficient efficacy

scientific article published on 01 October 2018

Magnetic resonance imaging analysis of the spread of local anesthetic solution after ultrasound-guided lateral thoracic paravertebral blockade: a volunteer study.

scientific article published in May 2013

Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients – A prospective, parallel group, open-labeled, controlled, phase IV, single center clinical trial

scientific article published on 10 May 2019

Penetration of doripenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers.

scientific article published on 14 November 2011

Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses.

scientific article

Penetration of linezolid into synovial fluid and muscle tissue after elective arthroscopy

scientific article published in October 2017

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

scientific article

Pharmacodynamics of piperacillin in severely ill patients evaluated by using a PK/PD model.

scientific article

Pharmacokinetic Aspects of Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitors.

scientific article published on 23 July 2015

Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients.

scientific article

Pharmacokinetics of Cefuroxime in Synovial Fluid

scientific article published on 7 August 2017

Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.

scientific article published in June 2012

Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens

scientific article published on 17 September 2017

Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis

scientific article

Pharmacokinetics of single- and multiple-dose oral clarithromycin in soft tissues determined by microdialysis.

scientific article published on 2 July 2007

Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers.

scientific article

Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration

scientific article published on 01 October 2018

Pharmacokinetics of the local anesthetic ropivacaine after transversus abdominis plane block in healthy volunteers.

scientific article published on 27 October 2011

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier

scientific article published on 03 March 2016

Pilot investigation on long-term subcutaneous microdialysis: proof of principle in humans.

scientific article published on 13 October 2012

Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial

scientific article published on 01 August 2019

Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial

scientific article published in 2019

Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis.

scientific article published on 24 August 2005

Plasma protein binding may reduce antimicrobial activity by preventing intra-bacterial uptake of antibiotics, for example clindamycin

scientific article published on 01 November 2010

Pre-vaccination immunity and immune responses to a cell culture-derived whole-virus H1N1 vaccine are similar to a seasonal influenza vaccine.

scientific article

Prospective evaluation of the performance of [68Ga]Ga-PSMA-11 PET/CT(MRI) for lymph node staging in patients undergoing superextended salvage lymph node dissection after radical prostatectomy

scientific article published on 29 June 2019

Protein binding of antimicrobials: methods for quantification and for investigation of its impact on bacterial killing.

scientific article published on January 2009

Removal of fractured endodontic instruments using an Nd:YAG laser.

scientific article

Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients

scientific article published on 01 September 2019

Reply: To PMID 23462262

scientific article published on 01 October 2013

Rifaximin Reduces the Number and Severity of Intestinal Lesions Associated With Use of Nonsteroidal Anti-Inflammatory Drugs in Humans.

scientific article

Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response

scientific article

Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial.

scientific article published on 10 May 2013

Safety and immunogenicity of a vero cell culture-derived whole-virus H5N1 influenza vaccine in chronically ill and immunocompromised patients

scientific article

Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid.

scientific article

Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil

scientific article published on 4 April 2016

Single-dose pharmacokinetics of fosfomycin during continuous venovenous haemofiltration

scientific article published on 16 June 2006

Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents

scientific article published on 26 February 2020

Target site antimicrobial activity of colistin might be misestimated if tested in conventional growth media.

scientific article

Target site concentrations of ciprofloxacin after single intravenous and oral doses

scientific article published on December 2002

Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of the food effect

scientific article published on 17 August 2018

Target site pharmacokinetics of linezolid after single and multiple doses in diabetic patients with soft tissue infection

article

The European Association for Clinical Pharmacology and Therapeutics-25 years' young and going strong

scientific article published on 16 May 2019

The impact of perioperative atelectasis on antibiotic penetration into lung tissue: an in vivo microdialysis study.

scientific article published on 14 May 2008

The influence of different peritoneal dialysis fluids on the in vitro activity of ampicillin, daptomycin, and linezolid against Enterococcus faecalis.

scientific article published on 4 September 2015

The non-invasive serum biomarker soluble Axl accurately detects advanced liver fibrosis and cirrhosis

scientific article published on 26 October 2017

The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration.

scientific article

Tissue pharmacokinetics of ertapenem at steady-state in diabetic patients with leg infections

scientific article published on 04 December 2012

Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance.

scientific article

Tissue pharmacokinetics of telavancin in healthy volunteers: a microdialysis study.

scientific article published on 11 July 2016

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

scientific article published on 29 April 2019

Understanding the Activity of Antibiotics in Cerebrospinal Fluid in vitro

scientific article

Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues

scientific article published on 28 March 2014

Vaccines Targeting PCSK9: A Promising Alternative to Passive Immunization with Monoclonal Antibodies in the Management of Hyperlipidaemia?

scientific article published on 01 June 2018

Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.

scientific article

[11C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans.

scientific article published on 5 September 2011

[18F]Ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans.

scientific article published on October 2004

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