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List of works by Joost H A Martens

AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis

scientific article published on 24 December 2016

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

scientific article

BLUEPRINT: mapping human blood cell epigenomes

scientific article (publication date: October 2013)

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

scientific article published on 14 December 2017

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

scientific article published on 18 April 2019

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

article

CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis

scientific article published on 15 February 2017

Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.

scientific article published on August 2012

Characterization of plant proteins that interact with cowpea mosaic virus '60K' protein in the yeast two-hybrid system.

scientific article

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

scientific article published on 01 January 2019

Comparative analysis of neutrophil and monocyte epigenomes

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

scientific article published on 24 February 2014

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.

scientific article published on November 2016

Dual promoter usage as regulatory mechanism of let-7c expression in leukemic and solid tumors.

scientific article published on 17 March 2014

Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

scientific article published on 01 September 2018

E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer

scientific article published in Scientific Reports

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

scientific article published on September 2014

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia

scientific article published on 19 April 2018

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

scientific article

Genome-wide binding of transcription factors in inv(16) acute myeloid leukemia.

scientific article published on 20 June 2014

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

scientific article published on 18 January 2011

Genome-wide interplay of nuclear receptors with the epigenome ⬇️

scientific article published on October 20, 2010

Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization

scientific article

Histone modification patterns associated with the human X chromosome

scientific article

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

scientific article published on 23 January 2017

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

scientific article

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

scientific article (publication date: December 2003)

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

scientific article

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

scientific article published on 29 April 2021

RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs

scientific article published on 01 February 2019

Recent insights into Histone Acetyltransferase-1: biological function and involvement in pathogenesis

scientific article published on 04 October 2020

Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

scientific article

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

scientific article published on 19 January 2021

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

scientific article published on 26 June 2014

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

scientific article

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

scientific article published in November 2016

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

scientific article published on 16 April 2021

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

scientific article published on 23 December 2019

The genome-wide molecular signature of transcription factors in leukemia.

scientific article published on 06 May 2014

The molecular signature of oncofusion proteins in acute myeloid leukemia.

scientific article published on 11 April 2010

The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.

scientific article published on 6 July 2015

The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

scientific article published on 21 May 2018

The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells.

scientific article published on 15 August 2013

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

scientific article published on 15 September 2017

Transcriptional diversity during lineage commitment of human blood progenitors

scientific article

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

scientific article

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

scientific article

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

scientific article

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis

scientific article published on 22 December 2017

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

scientific article published on 20 February 2017

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

scientific article

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