List of works by Siamon Gordon

A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

scientific article

A sensitive solid-phase assay for identification of class A macrophage scavenger receptor ligands using cell lysate

scientific article published on 25 October 2007

A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles

scientific article

Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages

scientific article

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways ⬇️

scientific article

Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype

scientific article

Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains

scientific article

Adhesion-GPCRs: emerging roles for novel receptors

scientific article published on 11 September 2008

Alternative activation of macrophages

scientific article (publication date: 2003)

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion

scientific article

Alternative activation of macrophages: immune function and cellular biology

scientific article published on 05 March 2009

Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor

scientific article

An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?

scientific article published on 13 May 2013

Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies

scientific article published on May 2003

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

scientific article published on 4 April 2013

Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target

scientific article published on 26 April 2004

Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif

scientific article

B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion

scientific article

C-type lectin-like receptors on myeloid cells

scientific article

CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses

scientific article published on 24 April 2015

CD169+ macrophages at the crossroads of antigen presentation

scientific article published on 21 December 2011

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

scientific article

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

scientific article published on 2 March 2016

Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand

scientific article published on April 2008

Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice

scientific journal article

Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.

scientific article

Commentary: C-type lectins on the macrophage cell surface--recent findings

scientific article published on January 2004

Conserved domains of the class A scavenger receptors: evolution and function

scientific article published on January 2009

Costimulation via CD55 on human CD4+ T cells mediated by CD97

scientific article

Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis

scientific article

Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.

scientific article

DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance

scientific article published on 9 June 2015

Dectin-1 and its role in the recognition of beta-glucans by macrophages

scientific article published on February 2004

Dectin-1 escape by fungal dimorphism

scientific article

Dectin-1 is a major beta-glucan receptor on macrophages

scientific journal article

Dectin-1 is required for beta-glucan recognition and control of fungal infection

scientific article published on 10 December 2006

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

scientific article published on 10 August 2004

Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo

scientific article published on July 2005

Development of a specific system for targeting protein to metallophilic macrophages

scholarly article

Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching

scientific article

Divergent roles for C-type lectins expressed by cells of the innate immune system

scientific article published in November 2004

Diversity and plasticity of mononuclear phagocytes

scientific article published on September 2011

Do macrophage innate immune receptors enhance atherogenesis?

scientific article published in November 2003

EMR1, the human homolog of F4/80, is an eosinophil-specific receptor

scientific article (publication date: October 2007)

EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20

scientific journal article

Elie Metchnikoff, the Man and the Myth.

scientific article published on 3 February 2016

Elie Metchnikoff: father of natural immunity

scientific article

Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse

scientific article published on 24 May 2005

Erratum for Maler et al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages".

scientific article published on 26 September 2017

Essential role of DAP12 signaling in macrophage programming into a fusion-competent state

scientific article published on 28 October 2008

Evasion of macrophage scavenger receptor A-mediated recognition by pathogenic streptococci

scientific article

Expression of functionally different dectin-1 isoforms by murine macrophages

scientific article published on May 2006

Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen

scientific article published in October 2005

F4/80 and the related adhesion-GPCRs

scientific article

F4/80: the macrophage-specific adhesion-GPCR and its role in immunoregulation.

scientific article published on January 2010

Formation of distinct chromatin conformation signatures epigenetically regulate macrophage activation

scientific article

Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth

scientific article

From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years

scientific article (publication date: 2015)

Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages

scientific article published in December 2004

Fungal β-Glucans and Mammalian Immunity ⬇️

scientific article published on September 1, 2003

G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA.

scientific article published on 29 September 2015

Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins

scientific article

Genetic deletion of dectin-1 does not affect the course of murine experimental colitis

scientific article

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

scientific article published on 4 January 2013

Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population

scientific article

Glycosylation influences the lectin activities of the macrophage mannose receptor

scientific article

Glycosylation influences the ligand binding activities of mannose receptor

scientific article published in January 2005

Highlights of 10 years of immunology in Nature Reviews Immunology

scientific article published on 23 September 2011

Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation

scientific article

IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni

scientific article published in August 2003

Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes

scientific journal article

Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay

scientific article published on September 2006

Immune recognition of fungal beta-glucans

scientific article

Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis

scientific article published in December 2003

Impaired phagocytic mechanism in annexin 1 null macrophages

scientific article published on 24 April 2006

Inactivation of the F4/80 glycoprotein in the mouse germ line

scientific article published on November 2002

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection

scientific article published on December 2011

Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige mice

scientific article published in July 2006

Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry

scientific article published on March 2011

Isolation and culture of murine macrophages.

scientific article published in January 2005

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages

scientific article published on August 2017

Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis

scientific article published on March 2009

Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival

scientific article

Ligand recognition by antigen-presenting cell C-type lectin receptors

scientific article

Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides

scientific article

MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis

scientific article

Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules

scientific article published on January 2007

Macrophage heterogeneity and tissue lipids

scientific article published on January 2007

Macrophage heterogeneity in tissues: phenotypic diversity and functions

scientific article

Macrophage heterogeneity: a personal scientific journey

scientific article published on June 2012

Macrophage pattern recognition receptors in immunity, homeostasis and self tolerance.

scientific article published on January 2009

Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E.

scientific article published on December 2009

Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer

scientific article published on 27 February 2013

Macrophage scavenger receptors and host-derived ligands

scientific article published on November 2007

Macrophage-specific gene expression: current paradigms and future challenges

scientific article

Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice

scientific article

Method for selecting and enriching cells expressing low affinity ligands for cell surface receptors

scientific article published on May 2005

Molecular mediators of macrophage fusion

scientific article published on 03 September 2009

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

scientific article published on 23 November 2015

Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner

scientific article (publication date: 13 June 2003)

Murine pattern recognition receptor dectin-1 is essential in the development of experimental autoimmune uveoretinitis

scientific article published on 24 July 2015

Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers ⬇️

scientific article published on December 1, 2003

Newly Formed Endothelial Cells Regulate Myeloid Cell Activity Following Spinal Cord Injury via Expression of CD200 Ligand

scientific article

Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge

scientific article

Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation

scientific article published on 20 October 2015

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype

scientific article

Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection

scientific article published on 19 May 2010

Pathogen recognition or homeostasis? APC receptor functions in innate immunity

scientific article published in June 2004

Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo

scientific article published in August 2003

Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands

scientific article published on January 2008

Pattern recognition receptors: doubling up for the innate immune response

scientific article

Phagocytosis: An Immunobiologic Process

scientific article published on March 2016

Physiological roles of macrophages

scientific article published on 9 February 2017

Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif

scientific article

Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors

scientific article published on 11 February 2008

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection

scientific article

Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells

scientific article published on 13 July 2006

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

scientific article published on 11 January 2007

Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor

scientific article

Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor

scientific article published on 3 January 2006

Role of macrophage scavenger receptors in atherosclerosis

scientific article published on 02 March 2012

Scavenger receptor A: a new route for adenovirus 5.

scientific article published in March 2009

Scavenger receptors in innate immunity

scientific article

Scavenger receptors: role in innate immunity and microbial pathogenesis

scientific article published on 22 April 2009

Sinusoidal immunity: macrophages at the lymphohematopoietic interface

scientific article

Soluble Dectin-1 as a tool to detect beta-glucans

scientific article published on 23 June 2006

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis

scientific article

Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor

scientific article published in February 2006

Targeting a monocyte subset to reduce inflammation

scientific article published on June 2012

The EGF-TM7 family: a postgenomic view

scientific article (publication date: 2004)

The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4.

scientific article

The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus

scientific article

The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages

scientific article (publication date: October 2002)

The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose

scientific article published on 19 January 2006

The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses

scientific article

The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans

scientific article

The evolution of our understanding of macrophages and translation of findings toward the clinic

scientific article published on December 2014

The interaction of macrophage receptors with bacterial ligands

scientific article published on 22 November 2006

The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance

scientific article

The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia

scientific article

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges

scientific article published on 11 December 2008

The macrophage: past, present and future

scientific article published on November 2007

The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity

scientific article published on 27 June 2008

The mannose receptor mediates dengue virus infection of macrophages

scientific article published on 8 February 2008

The mannose receptor: linking homeostasis and immunity through sugar recognition

scientific article published in February 2005

The many roles of the class A macrophage scavenger receptor

scientific article

The molecular basis of macrophage fusion

scientific article

The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.

scientific article

The potential for Toll-like receptors to collaborate with other innate immune receptors

scientific article published in August 2004

The role of Dectin-1 in antifungal immunity

scientific article published in January 2004

The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages

scientific article (publication date: 15 January 2004)

The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model

scientific article

The role of macrophages in inflammatory bowel diseases

scientific article published on 14 May 2009

The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon

scientific article published on 31 January 2011

The role of scavenger receptors in pathogen recognition and innate immunity

scientific article published in January 2004

The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion

scientific article

Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors

scientific article

Tissue macrophage heterogeneity: issues and prospects

scientific article published on 20 June 2013

Tissue macrophages: heterogeneity and functions

scientific article

Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression

scientific journal article

Unravelling mononuclear phagocyte heterogeneity

scientific article

Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2.

scientific article published on 7 May 2009

Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond

scientific article published on August 2016

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