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List of works by Long-Sen Chang

2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents

scientific article

A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling

scientific article published on June 25, 2011

A Turn-on Fluorescence Sensor for Heparin Detection Based on a Release of Taiwan Cobra Cardiotoxin from a DNA Aptamer or Adenosine-Based Molecular Beacon.

scientific article published on 19 February 2018

Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1.

scientific article

Antibacterial and membrane-damaging activities of mannosylated bovine serum albumin

scientific article

Antibacterial and membrane-damaging activities of β-bungarotoxin B chain.

scientific article published on 8 November 2012

Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells

scientific article

Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells ⬇️

scientific article published on October 31, 2011

Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway

scientific article published on 29 August 2009

Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

scientific article

Arecoline‐induced death of human leukemia K562 cells is associated with surface up‐modulation of TNFR2 ⬇️

scientific article published on May 1, 2012

B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells

scientific article

Bactericidal effect of Naja nigricollis toxin γ is related to its membrane-damaging activity ⬇️

scientific article published on July 5, 2011

Beta-Bungarotoxin induction of neurite outgrowth in NB41A3 cells

scientific article

Both A chain and B chain of beta-bungarotoxin are functionally involved in the facilitation of spontaneous transmitter release in Xenopus nerve-muscle cultures

scientific article published in March 2004

Bovine serum albumin with glycated carboxyl groups shows membrane-perturbing activities

scientific article published on 13 October 2014

Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells

scientific article published on 21 May 2013

CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability ⬇️

scientific article published on September 3, 2012

Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway

scientific article published in September 2010

Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells

scientific article published on January 2010

Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells

scientific article published on 17 August 2015

Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells.

scientific article

Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway ⬇️

scientific article published on June 7, 2012

Cardiotoxin III suppresses hepatocyte growth factor-stimulated migration and invasion of MDA-MB-231 cells

scientific article

Cardiotoxin III-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation in K562 cells

scientific article published on 01 May 2008

Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization

scientific article

Characterization and functional aspects of human ninein isoforms that regulated by centrosomal targeting signals and evidence for docking sites to direct gamma-tubulin

scientific article published on 13 September 2006

Characterization and gene organization of Taiwan banded krait (Bungarus multicinctus) gamma-bungarotoxin

scientific article published in May 2002

Chemical modification of arginine residues of Notechis scutatus scutatus notexin

scientific article published in October 2004

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells

scientific article

Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells

scientific article published on 23 May 2013

DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cells

scientific article published on 26 May 2007

DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways ⬇️

scientific article published on January 5, 2013

DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins

scientific article published on 5 March 2016

Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon

scientific article published on 07 January 2017

Differential binding to phospholipid bilayers modulates membrane-damaging activity of Naja naja atra cardiotoxins

scientific article published on 18 May 2009

Disulfide isomerization and thiol-disulfide exchange of long neurotoxins from the venom of Ophiophagus hannah

scientific article published on 23 August 2006

Divergence of genes encoding B chains of beta-bungarotoxins

scientific article published on 2 February 2006

Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells

scientific article

Effect of cholesterol on membrane-damaging activity of Naja nigricollis toxin gamma toward phospholipid vesicles

scientific article

Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells

scientific article published on January 2009

Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel

scientific article

Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins

scientific article

Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway

scientific article

Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins

scientific article (publication date: June 2006)

Functional implication with the metal-binding properties of KChIP1 ⬇️

scientific article published on November 14, 2003

Functional role of EF-hands 3 and 4 in membrane-binding of KChIP1.

scientific article published in June 2009

Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells

scientific article

Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells

scientific article

Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells

scientific article published on 12 September 2016

Guanidination of notexin alters its membrane-damaging activity in response to sphingomyelin and cholesterol ⬇️

scientific article published on December 1, 2010

Guanidination of notexin promotes its phospholipase A2 activity-independent fusogenicity on vesicles with lipid-supplied negative curvature ⬇️

scientific article published on October 23, 2011

Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells

scientific article published on 15 June 2016

Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl

scientific article published on 20 June 2013

Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra

scientific article published in October 2009

Induction of apoptosis by DC-81-indole conjugate agent through NF-kappaB and JNK/AP-1 pathway

scientific article

Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells

scientific article

Inhibition of Src activation with cardiotoxin III blocks migration and invasion of MDA-MB-231 cells

scientific article published on 7 August 2013

Inhibitory action of naphtho[1,2-b]furan-4,5-dione on hepatocyte growth factor-induced migration and invasion of MDA-MB-231 cells: mechanisms of action

scientific article

Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity

scientific article published on March 2010

Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells

scientific article published on 25 May 2008

Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells

scientific article published on 29 March 2007

Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.

scientific article published on 25 January 2007

Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells

scientific article

Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

scientific article published on 6 February 2010

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells

scientific article published on 13 October 2007

JNK1/c-Jun and p38 alpha MAPK/ATF-2 pathways are responsible for upregulation of Fas/FasL in human chronic myeloid leukemia K562 cells upon exposure to Taiwan cobra phospholipase A2.

scientific article published in October 2009

KChIP3: a binding protein for Taiwan banded krait beta-bungarotoxin

scientific article

Lipid domain formation modulates activities of snake venom phospholipase A(2) enzymes

scientific article published on 10 August 2010

Lys-64 of the A chain is involved in the enzymatic activity and neurotoxic effect of beta-bungarotoxin

scientific article published in February 2005

Membrane-bound conformation of Naja nigricollis toxin gamma affects its membrane-damaging activity

scientific article published on 11 December 2008

Membrane-damaging activities of mannosylated ovalbumin are involved in its antibacterial action

scientific article published on 19 December 2017

Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity

scientific article published on 7 May 2011

Membrane-damaging activity with A chain and B chain of beta-bungarotoxin

scientific article

Modulated mechanism of phosphatidylserine on the catalytic activity of Naja naja atra phospholipase A2 and Notechis scutatus scutatus notexin

scientific article published on 17 October 2014

Molecular cloning and evolution of the genes encoding the precursors of taiwan cobra cardiotoxin and cardiotoxin-like basic protein

scientific article published on 01 December 2004

Muscarinic toxin-like proteins from Taiwan banded krait (Bungarus multicinctus) venom: purification, characterization and gene organization

scientific article published on September 2002

Mutagenesis studies on the N-terminus and Thr54 of Naja naja atra (Taiwan cobra) chymotrypsin inhibitor.

scientific article

Mutations on N-terminal region of Taiwan cobra phospholipase A(2) result in structurally distorted effects

scientific article

Mutations on the N-terminal region abolish differentially the enzymatic activity, membrane-damaging activity and cytotoxicity of Taiwan cobra phospholipase A2

scientific article published on 09 October 2007

NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-α-treated human leukemia U937 cells

scientific article published on 07 August 2015

NMR solution structure of a Chymotrypsin inhibitor from the Taiwan cobra Naja naja atra

scientific article published on 26 July 2013

Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes ⬇️

scientific article published on May 5, 2012

Naja nigricollis CMS-9 enhances the mitochondria-mediated death pathway in adaphostin-treated human leukaemia U937 cells ⬇️

scientific article published on November 1, 2011

Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells

scientific article

Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells

scientific article

Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation

scientific article

Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway

scientific article published on 2 April 2010

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways

scientific article published on 26 October 2013

Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation

scientific article published on 07 November 2018

Notexin upregulates Fas and FasL protein expression of human neuroblastoma SK-N-SH cells through p38 MAPK/ATF-2 and JNK/c-Jun pathways

scientific article

Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation

scientific article

Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells

scientific article

Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells

scientific article published on 28 June 2008

Novel neurotoxins from Taiwan banded krait (Bungarus multicinctus) venom: purification, characterization and gene organization ⬇️

scientific article published on September 1, 2003

Organization and phylogenetic analysis of kappa-bungarotoxin genes from Bungarus multicinctus (Taiwan banded krait).

scientific article published on June 2002

Ovalbumin with Glycated Carboxyl Groups Shows Membrane-Damaging Activity

scientific article published on 28 February 2017

Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles ⬇️

scientific article published on August 30, 2011

Phospholipase A2 activity-independent membrane-damaging effect of notexin

scientific article published in August 2007

Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells

scientific article

Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+/p38alpha MAPK-mediated activation of c-Jun and ATF-2 pathways

scientific article published on 16 May 2010

Protein-protein interactions of KChIP proteins and Kv4.2

scientific article

Purification and characterization of Ophiophagus hannah cytotoxin-like proteins

scientific article published on 29 June 2006

Purification and characterization of Taiwan cobra venom proteins with weak toxicity

scientific article published on 01 January 2005

Purification and characterization of a neurotoxin from the venom of Ophiophagus hannah (king cobra).

scientific article

Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2 ⬇️

scientific article published on June 1, 2012

Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression

scientific article published on 12 February 2015

Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation

scientific article published on 31 August 2017

ROS-mediated p38alpha MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A(2)-treated U937 cells

scientific article published on 01 June 2009

Reactive oxygen species and p38 mitogen-activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin-gamma

scientific article published in August 2009

Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles

scientific article published on 6 August 2009

Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length

scientific article published in August 2013

Separation and structure-function studies of Taiwan cobra cardiotoxins

scientific article

Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells

scientific article published on 12 October 2014

Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells

scientific article

Suppression of ADAM17-mediated Lyn/Akt pathways induces apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhibitor-like protein-1 uncovers the cytotoxic mechanism

scientific article

Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NFκB activation in piceatannol-treated human leukemia U937 cells ⬇️

scientific article published on June 15, 2012

Suppression of ERK signaling evokes autocrine Fas-mediated death in arachidonic acid-treated human chronic myeloid leukemia K562 cells

scientific article published in March 2010

Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids

scientific article

Synthesis and biological evaluation of thiobenzanilides as anticancer agents

scientific article

Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds

scientific article published on 10 October 2013

Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents

scientific article published on 29 April 2010

Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells

scientific article

Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells

scientific article published on 13 January 2016

Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization

scientific article published on 4 December 2007

Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization

scientific article published on 15 December 2004

Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells

scientific article

Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells

scientific article published on 27 May 2014

Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells.

scientific article

The Association Between p38 MAPK-Mediated TNF-α/TNFR2 up-Regulation and 2-(4-Aminophenyl)-7-Methoxybenzothiazole-Induced Apoptosis in Human Leukemia U937 Cells

scientific article

The mechanism of cytotoxicity by Naja naja atra cardiotoxin 3 is physically distant from its membrane-damaging effect

scientific article published on 27 June 2007

The organization of the genes encoding the A chains of beta-bungarotoxins: evidence for the skipping of exon

scientific article published on October 2002

The structural and functional contribution of N-terminal region and His-47 on Taiwan cobra phospholipase A2.

scientific article published in March 2008

The structural events associated with the binding of divalent cations to beta-bungarotoxin

scientific article published in February 2005

Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation

scientific article

p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells

scientific article published on 9 July 2008

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