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List of works by Seppo Parkkila

A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi

scientific article published on 10 July 2013

A distinct carbonic anhydrase in the mucus of the colon of humans and other mammals.

scientific article published in February 2005

A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi

scientific article published on 06 November 2014

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

scientific article published on 01 December 2020

A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system

scientific article

Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases

scientific article published on 16 June 2011

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines

scientific article published on 01 February 2019

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi

scientific article published on 07 July 2018

Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.

scientific article published on 16 April 2018

Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV

Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?

scientific article published on March 2004

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.

scientific article published on 21 May 2016

Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype

scientific article published on 20 November 2007

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.

scientific article published on 13 March 2018

An overview of the distribution and function of carbonic anhydrase in mammals.

scientific article

An update on anticancer drug development and delivery targeting carbonic anhydrase IX.

scientific article published on 23 November 2017

An update on carbonic anhydrase-related proteins VIII, X and XI.

scientific article published on 07 January 2013

Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme

scientific article published on 21 May 2010

Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes.

scientific article published on 10 September 2012

Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae.

scientific article published in December 2018

Anti-carbonic anhydrase autoantibodies and serum beta-2 microglobulin correlate with the ClinESSDAI score in patients with Sjögren's syndrome

scientific article published on 5 January 2017

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis.

scientific article published on 18 September 2015

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

scientific article

Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry

scientific article

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

scientific article published on 01 December 2020

Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

scientific article

Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans

scientific article published on 21 January 2014

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

scientific article published on 14 April 2020

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

scientific article published on 28 October 2020

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development.

scientific article published on 17 August 2012

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies

scientific article

Carbonic Anhydrase VI in Skin Wound Healing Study on Car6 Knockout Mice

scientific article published on 18 July 2020

Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei.

scientific article published on March 2017

Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation.

scientific article

Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy.

scientific article published on 18 September 2012

Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification

scientific article (publication date: June 2002)

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.

scientific article published on 12 May 2009

Carbonic anhydrase activity in peripheral T-lymphocytes and appearance of the activity during their maturation in the thymus. A histochemical demonstration

scientific article published on 01 January 1989

Carbonic anhydrase autoantibodies and sicca symptoms in primary Sjögren´s syndrome

scientific article published on 01 May 2012

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.

scientific article published on September 2016

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.

scientific article published on 13 September 2008

Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.

scientific article published on 25 December 2008

Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2

scientific journal article

Carbonic anhydrase isozymes II, IX, and XII in uterine tumors

scientific article published on 25 October 2011

Carbonic anhydrase isozymes IX and XII in gastric tumors

scientific article (publication date: July 2003)

Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer.

scientific article

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.

scientific article published on 23 May 2018

Carbonic anhydrase related proteins: molecular biology and evolution.

scientific article published on January 2014

Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma

scientific article published on 31 July 2018

Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours.

scientific article

Carbonic anhydrases in the mouse harderian gland.

scientific article

Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1

scientific article published on 11 June 2019

Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig.

scientific article published in October 1993

Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV.

scientific article published on January 2007

Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase

scientific article

Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins

scientific article

Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates

scientific article

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.

scientific article published on 31 August 2012

Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study ⬇️

scientific article published on April 1, 1998

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan

Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.

scientific article published on 13 September 2013

Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth <i>Gyrodactylus salaris</i>

scientific article published on 31 May 2022

Covalent adducts of proteins with acetaldehyde in the liver as a result of acetaldehyde administration in drinking water

scientific article published on 01 December 2000

Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation

scientific article published on 01 April 1994

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

scientific article

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

scientific article

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

scientific article

Demonstration of a bioactive elastin-derived peptide (Val-Gly-Val-Ala-Pro-Gly) in vascular lesions characterised by the segmental destruction of media

scientific article published on 01 January 1994

Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer.

scientific article published in March 2008

Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.

scientific article published on 13 December 2013

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

scientific article published on 01 December 2020

Detection of cervical metastases of thyroid medullary carcinoma by MoAb anti-CEA scintigraphy and immunohistochemistry ⬇️

scientific article published on September 1, 1995

Development and characterization of new monoclonal antibodies against human recombinant CA XII.

scientific article

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors

scientific article

Discovery of new organoselenium compounds as antileishmanial agents

scientific article published on 31 January 2019

Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests.

scientific article published on 08 September 2014

Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse

scientific article

Evidence of acetaldehyde-protein adduct formation in rat brain after lifelong consumption of ethanol

scientific article published on 01 September 2000

Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa

scientific article

Expression of cancer-related carbonic anhydrases IX and XII in normal skin and skin neoplasms

scientific article published on 3 April 2014

Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2.

scientific article published in July 2002

Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development?

scientific article

Expression of carbonic anhydrase in the fetal eye and extra-ocular tissues.

scientific article

Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues.

scientific article published in March 2004

Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart

scientific article

Expression of testosterone-dependent enzyme, carbonic anhydrase III, and oxidative stress in experimental alcoholic liver disease

scientific article published on 01 November 1999

Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia.

scientific article published on 23 November 2013

Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts

scientific article (publication date: July 2001)

Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours

scientific article published on 01 December 2006

Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

scientific article published on 8 February 2014

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation

scientific journal article

Expression studies of neogenin and its ligand hemojuvelin in mouse tissues.

scientific article published on 18 September 2006

Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi

scientific article published on 28 October 2020

Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide.

scientific article published on 6 September 2016

Free radicals in alcoholic myopathy: indices of damage and preventive studies.

scientific article

Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C.

scientific article published in October 2005

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

scientific article published on 11 September 2010

Generation of aldehyde-derived protein modifications in ethanol-exposed heart.

scientific article published in December 2003

Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide

scientific article published on 01 September 2002

Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum

scientific article

Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach

scientific article

Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein.

scientific article

HFE gene knockout produces mouse model of hereditary hemochromatosis

scientific article

HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia

scientific article published on 01 June 2001

Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury

scientific article published on 01 May 1999

Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy

scientific article published in January 2005

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β 2 -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells ⬇️

scientific article published on November 11, 1997

Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes

scientific article published on 16 March 2016

Hsp27 and its expression pattern in diffusely infiltrating astrocytomas.

scientific article

Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2

scientific article published on 01 April 2003

Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.

scientific article published on 23 September 2008

Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies.

scientific article published on November 2007

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase

scientific article published on 7 December 2017

Identification and inhibition of carbonic anhydrases from nematodes.

scientific article

Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption ⬇️

scientific article published on April 1, 1991

Immunohistochemistry of carbonic anhydrase in human placenta and fetal membranes

scientific article published on 01 February 1994

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

scientific article published on 01 December 2020

Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish

scientific article (publication date: 2015)

Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs

scientific article published on 01 October 1999

Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children

scientific article published on 31 December 2020

Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides

scientific article

Inhibition of the β-carbonic anhydrase from the protozoan pathogen <i>Trichomonas vaginalis</i> with sulphonamides

scientific article published on 01 December 2021

Innovative molecular diagnosis of Trichinella species based on β-carbonic anhydrase genomic sequence.

scientific article published on 7 December 2015

Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists

article

Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein.

scientific article published in August 2008

Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney

scientific article (publication date: September 2003)

Long-term ethanol consumption and macrocytosis: diagnostic and pathogenic implications.

scientific article published in April 2006

Membrane-bound carbonic anhydrases in osteoclasts

scientific article published on 22 December 2006

Multiple endocrine neoplastic-associated thymic carcinoid tumour in close relatives: octreotide scan as a new diagnostic and follow-up modality. Two case reports.

scientific article

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

scientific article published on 01 December 2018

Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome

scientific article published on 22 March 2011

Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva ⬇️

scientific article published on September 16, 2011

Pathogenesis of hereditary hemochromatosis: genetics and beyond.

scientific article

Phylogeny and expression of carbonic anhydrase-related proteins.

scientific article

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases

scientific article published on 15 June 2019

Polarized expression of a band 3-related protein in mammalian sperm cells.

scientific article published on August 1993

Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders

scientific article published on 01 February 2002

Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region.

scientific article published in August 2001

Protein–Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I–XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family

scientific article published on 18 May 2012

R-Ras regulates vascular permeability, but not overall healing in skin wounds

scientific article published on 21 December 2018

Recent advances in alcohol-induced adduct formation.

scientific article published in July 2005

Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.

scientific article published on January 2008

Role of carbonic anhydrases in skin wound healing

scientific article

Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women

scientific article published on 01 August 2003

Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands

scientific article (publication date: May 2001)

Segmental mediolytic arteritis--electronmicroscopic and immunohistochemical study

scientific article published on 01 January 1994

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

scientific article published on 01 October 1995

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.

scientific article published in March 2012

Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study

scientific article published on 01 February 2010

Serum IgG and IgE antibodies against mold-derived antigens in patients with symptoms of hypersensitivity

scientific article published on 01 March 2001

Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches.

scientific article published on June 2008

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan

scientific article published in 2018

Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster.

scientific article published on 9 May 2014

Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase

scientific article published on 01 December 2020

Surveillance and diagnosis of zoonotic foodborne parasites.

scientific article published on 12 November 2017

T Tubules and Surface Membranes Provide Equally Effective Pathways of Carbonic Anhydrase-Facilitated Lactic Acid Transport in Skeletal Muscle ⬇️

scientific article published on December 13, 2010

Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity

scientific article published on 09 April 2020

The calcium-binding protein S100P in normal and malignant human tissues

scientific article

The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors

scientific article

The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver

scientific article published on 01 July 2007

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

scientific article

The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk

scientific article

The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV.

scientific article

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model

scientific article

The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors

scientific article

The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides

scientific article

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia

scientific article published on 01 November 2018

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

scientific article published on 01 December 2020

Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs

scientific article

Tumor-associated carbonic anhydrases and their clinical significance.

scientific article published on January 2006

Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload.

scientific article published on February 1996

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.

scientific article published on 4 July 2018

[Current aspects of alcohol-induced liver damage]

scientific article published on 01 January 1995

[Hereditary hemochromatosis]

scientific article published on 01 January 2000

[Scintigraphy detection of somatostatin receptor in tumor diagnosis]

scientific article published on 01 January 1996

β carbonic anhydrase is required for female fertility in Drosophila melanogaster.

scientific article

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

scientific article published on December 2017

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