List of works - Sharon Wein

Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice.

scientific article

Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.

scientific article

Choline analogues in malaria chemotherapy

scientific article

Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite

scientific article published on 31 May 2018

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.

scientific article published on 24 December 2008

Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.

scientific article published on 8 January 2014

Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.

scientific article published on 16 May 2012

Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials

scientific article published on 24 June 2019

Evaluation of bis-alkylamidoxime O-alkylsulfonates as orally available antimalarials.

scientific article published on 27 April 2012

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

scientific article published on 10 May 2010

Exploring prodrug approaches for albitiazolium and its analogues.

scientific article published in January 2014

Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites

scientific article published on 06 July 2020

High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.

scientific article published on 12 June 2017

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6.

scientific article published on 20 April 2017

Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.

scientific article published in March 2004

New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation

scientific article published on 04 January 2013

New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.

scientific article published on 7 July 2014

Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors ⬇️

scientific article published on November 2, 2010

Phenobarbital induces cytochrome P4501A2 hnRNA, mRNA and protein in the liver of C57BL/6J wild type and aryl hydrocarbon receptor knock-out mice

scientific article published on 01 March 1998

Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues

scientific article published on 25 April 2019

Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.

scientific article published on 21 February 2013

Quantitative analysis of a bis-thiazolium antimalarial compound, SAR97276, in mouse plasma and red blood cell samples, using liquid chromatography mass spectrometry.

scientific article published on 13 October 2007

Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

scientific article published on 10 March 2010

Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation

scientific article published on 03 August 2010

Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways.

scientific article published on January 2010

Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs.

scientific article published in January 2010

Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

scientific article published on 20 January 2017

Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny

scientific article published on 26 July 2018

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

scientific article published on August 2012

List of works by Sharon Wein

Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice.

Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.

Choline analogues in malaria chemotherapy

Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.

Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.

Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.

Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials

Evaluation of bis-alkylamidoxime O-alkylsulfonates as orally available antimalarials.

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

Exploring prodrug approaches for albitiazolium and its analogues.

Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites

High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6.

Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.

New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation

New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.

Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors ⬇️

Phenobarbital induces cytochrome P4501A2 hnRNA, mRNA and protein in the liver of C57BL/6J wild type and aryl hydrocarbon receptor knock-out mice

Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues

Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.

Quantitative analysis of a bis-thiazolium antimalarial compound, SAR97276, in mouse plasma and red blood cell samples, using liquid chromatography mass spectrometry.

Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation

Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways.

Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs.

Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate