List of works by Xiang Chen

A forest-based approach to identifying gene and gene gene interactions.

scholarly article

A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines.

scientific article

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures

scientific article published on 17 October 2019

Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier.

scientific article published on 23 July 2007

Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

scientific article

Automated interpretation of protein subcellular location patterns.

scientific article

Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics

scientific article

Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.

scientific article

CONSERTING: integrating copy-number analysis with structural-variation detection

scientific article

Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.

scientific article

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

scientific article published in Nature Communications

Combinatorial Screening Using Orthotopic Patient Derived Xenograft-Expanded Early Phase Cultures of Osteosarcoma Identify Novel Therapeutic Drug Combinations

article

Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome

scientific article

Detecting Genes and Gene-gene Interactions for Age-related Macular Degeneration with a Forest-based Approach

scientific article

Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests.

scientific article

Development and characterization of a human orthotopic neuroblastoma xenograft

scientific article

Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

scientific article published on 20 December 2019

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

scientific article

Human liver-derived cells stably modified for regulated proinsulin secretion function as bioimplants in vivo.

scientific article published on July 2002

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

scientific article published on 23 August 2018

LOT: a tool for linkage analysis of ordinal traits for pedigree data

scientific article

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

scientific article published on 14 February 2020

Memory management in genome-wide association studies.

scientific article

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.

scientific article published on 19 December 2018

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

scientific article published on 01 July 2018

Modelling gene regulation networks via multivariate adaptive splines.

scientific article

Molecular Detection and Analysis of Exosomes Using Surface-Enhanced Raman Scattering Gold Nanorods and a Miniaturized Device.

scientific article

Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers

scientific article published on 24 October 2019

Novel mutations target distinct subgroups of medulloblastoma.

scientific article

Nucleome Dynamics during Retinal Development

scientific article published on 04 September 2019

Objective clustering of proteins based on subcellular location patterns

scientific article

Orthotopic patient-derived xenografts of paediatric solid tumours

scientific article published on 30 August 2017

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.

scientific article published on 28 February 2018

Pediatric solid tumor genomics and developmental pliancy

scientific article

Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors

scientific article

RB1 gene inactivation by chromothripsis in human retinoblastoma

scientific article published on January 2014

Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

scientific article

Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

scientific article published in March 2018

Retinoblastoma from human stem cell-derived retinal organoids

scientific article published on 27 July 2021

Robust classification of subcellular location patterns in high resolution 3D fluorescence microscope images.

scientific article

Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

scientific article

Targeting oxidative stress in embryonal rhabdomyosarcoma.

scientific article published on December 2013

The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment

scientific article published on 16 January 2019

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.

scientific article published in May 2017

The genomic landscape of core-binding factor acute myeloid leukemias

scientific article

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.

scientific article

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

scientific article

The neoepitope landscape in pediatric cancers.

scientific article published on 31 August 2017

The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women

scientific article

The null distributions of test statistics in genomewide association studies

scientific article

VCF2CNA: A tool for efficiently detecting copy-number alterations in VCF genotype data and tumor purity

scientific article published on 17 July 2019

Willows: a memory efficient tree and forest construction package

scientific article

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