List of works - Lishomwa Ndhlovu

A decreased frequency of regulatory T cells in patients with common variable immunodeficiency

scientific article

A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties.

scientific article

Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART

scientific article published on 13 August 2021

Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection.

scientific article

Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children

scientific article

Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.

scientific article

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals

article

Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.

scientific article published on February 2016

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

scientific article

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population.

scientific article published on 16 February 2016

CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis

scientific article

Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression

scientific article published on 08 August 2018

Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

scientific article published on 21 March 2018

Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens

scientific article

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells

scientific article published on 01 August 2008

Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment

scientific article published on 15 September 2016

Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults

scientific article published on 28 June 2019

Concomitant evaluation of PMA+ionomycin-induced kinase phosphorylation and cytokine production in T cell subsets by flow cytometry.

scientific article published on 24 January 2014

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

scientific article published on 01 November 2002

Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

scientific article published in October 2002

Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

scientific article published on 01 September 2001

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19

scientific article published on 05 May 2020

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals

scientific article published on 26 November 2018

Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities.

scientific article

Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy.

scientific article

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

scientific article

Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques

scientific article

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

scientific article published on 05 October 2009

GITR co-signal in ILC2 controls allergic lung inflammation

scientific article published on 7 February 2018

Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling

article

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

scientific article published on 27 October 2013

Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment

scientific article published on 26 June 2019

HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.

scientific article published on 21 September 2011

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.

scientific article published on 4 April 2017

Hiding in plain sight - platelets, the silent carriers of HIV-1

scientific article published on 23 November 2020

High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy.

scientific article published on October 2016

IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease

scientific article

IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.

scientific article

Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.

scientific article

Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy

article

Impact of Myeloid Reservoirs in HIV Cure Trials

scientific article published on 01 April 2019

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism

scientific article published on 01 September 2018

In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection

scientific article published on 10 July 2018

Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population.

scientific article published on May 2009

LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.

scientific article published on 02 October 2013

Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease.

scientific article published on 2 September 2009

Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.

scientific article

Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy

scientific article published on 11 February 2016

Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy

scientific article published on 04 April 2016

Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities

article

Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients

scientific article published on 23 February 2016

P16-10. IL-2 therapy mediates expansion of Treg cells, maintains IL-17 expressing CD4+ T-cells and selectively suppresses HIV specific T-cell responses

article

P16-30. Induction of Tim-3 expression by the common gamma-chain cytokines IL-2, IL-7, IL-15 and IL-21.

scientific article

PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults

scientific article published on 01 May 2019

Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-α levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors.

scientific article published on 21 September 2013

Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection.

scientific article published on 21 March 2017

Preclinical development of HIvax: Human survivin highly immunogenic vaccines

scientific article published on July 2015

Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults

article

Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy.

scientific article published on 31 October 2013

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.

scientific article published on 16 December 2005

Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV

article

Role of Natural Killer Cells in HIV-Associated Malignancies.

scientific article published on 21 March 2017

S100B and its association with HIV-associated neurocognitive disorders

scientific article published on 05 July 2019

Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry ⬇️

scientific article published on January 22, 2013

Strategies to target non-T-cell HIV reservoirs

scientific article published on 25 March 2016

Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection

scientific article

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

scientific article

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

scientific journal article

T cell responses to human endogenous retroviruses in HIV-1 infection

scientific article

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

scientific article (publication date: 2016)

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

scientific article published on 17 April 2019

The meningeal lymphatic system: a route for HIV brain migration?

scientific article published on 16 November 2015

The role of HIV and monocytes/macrophages in adipose tissue biology

scientific article

Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-a

scientific article

Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines.

scientific article published on June 2017

List of works by Lishomwa Ndhlovu

A decreased frequency of regulatory T cells in patients with common variable immunodeficiency

A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties.

Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART

Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection.

Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children

Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals

Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population.

CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis

Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression

Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells

Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment

Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults

Concomitant evaluation of PMA+ionomycin-induced kinase phosphorylation and cytokine production in T cell subsets by flow cytometry.

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals

Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities.

Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy.

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

GITR co-signal in ILC2 controls allergic lung inflammation

Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment

HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.

Hiding in plain sight - platelets, the silent carriers of HIV-1

High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy.

IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease

IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.

Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.

Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy

Impact of Myeloid Reservoirs in HIV Cure Trials

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism

In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection

Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population.

LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.

Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease.

Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.

Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy

Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy

Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities

Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients

P16-10. IL-2 therapy mediates expansion of Treg cells, maintains IL-17 expressing CD4+ T-cells and selectively suppresses HIV specific T-cell responses

P16-30. Induction of Tim-3 expression by the common gamma-chain cytokines IL-2, IL-7, IL-15 and IL-21.

PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults

Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-α levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors.

Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection.

Preclinical development of HIvax: Human survivin highly immunogenic vaccines

Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults

Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy.

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.

Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV

Role of Natural Killer Cells in HIV-Associated Malignancies.

S100B and its association with HIV-associated neurocognitive disorders

Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry ⬇️

Strategies to target non-T-cell HIV reservoirs

Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

T cell responses to human endogenous retroviruses in HIV-1 infection

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

The meningeal lymphatic system: a route for HIV brain migration?

The role of HIV and monocytes/macrophages in adipose tissue biology

Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-a

Ultra-Deep Sequencing Analysis on HIV Drug-Resistance-Associated Mutations Among HIV-Infected Individuals: First Report from the Philippines.