List of works - Antonio Iavarone

The transcriptional network for mesenchymal transformation of brain tumours.

scientific article

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

scientific article published on January 2016

Id family of helix-loop-helix proteins in cancer

scientific article

Clonal evolution of glioblastoma under therapy.

scientific article

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

scientific article

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

scientific article published on 28 June 2006

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

scientific article

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

scientific article published on August 2009

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

scientific article published on January 17, 2012

Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.

scientific article published on 21 January 2015

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

scientific article

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

scientific article

Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.

scientific article

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

scientific article published on 6 March 2017

E protein transcription factors are required for the development of CD4(+) lineage T cells.

scientific article published on 15 March 2012

An anatomic transcriptional atlas of human glioblastoma.

scientific article

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.

scientific article

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F

scientific article

Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma

scientific article published on January 1, 2002

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum

scientific article published on March 15, 2010

E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.

scientific article published on June 2006

An ID2-dependent mechanism for VHL inactivation in cancer

scientific article published on 06 January 2016

Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer.

scientific article

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

scientific article published in October 2004

Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.

scientific article published on 15 November 2013

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

scientific article

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

scientific article published on 21 December 2016

A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

scientific article published in April 2018

FGFR-TACC gene fusions in human glioma

scientific article published on 16 November 2016

A metabolic function of FGFR3-TACC3 gene fusions in cancer.

scientific article published on 3 January 2018

The genomic landscape of schwannoma

scientific article published on 10 October 2016

Single-cell transcriptome analysis of lineage diversity in high-grade glioma.

scientific article

The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells

scientific article

CNS Anticancer Drug Discovery and Development Conference White Paper.

scientific article

The molecular landscape of glioma in patients with Neurofibromatosis 1

scientific article published on 10 December 2018

Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.

scientific article published on 27 June 2012

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

scientific article published on 6 March 2018

Id proteins in neural cancer.

scientific article published on February 2004

Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.

scientific article published on 7 July 2017

A tree shrew glioblastoma model recapitulates features of human glioblastoma

scientific article

RGBM: regularized gradient boosting machines for identification of the transcriptional regulators of discrete glioma subtypes.

scientific article

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas.

scientific article

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.

scientific article published on 4 May 2015

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

scientific article

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.

scientific article published on 16 May 2017

Detection of statistically significant network changes in complex biological networks

scientific article

Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features.

scientific article published on 4 October 2017

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1G93A mice.

scientific article published on 3 April 2018

Myc and differentiation: going against the current

scientific article published on 10 March 2014

List of works by Antonio Iavarone

The transcriptional network for mesenchymal transformation of brain tumours.

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Id family of helix-loop-helix proteins in cancer

Clonal evolution of glioblastoma under therapy.

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

E protein transcription factors are required for the development of CD4(+) lineage T cells.

An anatomic transcriptional atlas of human glioblastoma.

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F

Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum

E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.

An ID2-dependent mechanism for VHL inactivation in cancer

Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer.

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

FGFR-TACC gene fusions in human glioma

A metabolic function of FGFR3-TACC3 gene fusions in cancer.

The genomic landscape of schwannoma

Single-cell transcriptome analysis of lineage diversity in high-grade glioma.

The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells

CNS Anticancer Drug Discovery and Development Conference White Paper.

The molecular landscape of glioma in patients with Neurofibromatosis 1

Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

Id proteins in neural cancer.

Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.

A tree shrew glioblastoma model recapitulates features of human glioblastoma

RGBM: regularized gradient boosting machines for identification of the transcriptional regulators of discrete glioma subtypes.

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas.

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.

Detection of statistically significant network changes in complex biological networks

Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features.

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1G93A mice.

Myc and differentiation: going against the current

Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the &lt;i&gt;IDH1&lt;/i&gt; Mutation Status and Treatment Regimen

Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the <i>IDH1</i> Mutation Status and Treatment Regimen