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List of works by G F. Smith

Designing drugs to avoid toxicity

scientific article

Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles

scientific article published on 09 May 2019

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

scientific article published on 20 April 2015

Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure–activity relationship (SAR)

scientific article published on 27 August 2011

Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry

scientific article published on 7 February 2018

Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection-Mass Spectrometry

scientific article published on 11 September 2018

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications

scientific article

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

scientific article published on 18 April 2017

Medicinal chemistry by the numbers: the physicochemistry, thermodynamics and kinetics of modern drug design.

scientific article published on January 2009

Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

scientific article published on 26 November 2019

RNA as a small molecule druggable target

scientific article published on 23 October 2017

Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.

scientific article

Synthesis of Cyclic Peptidomimetics via a Pd-Catalyzed Macroamination Reaction

scientific article published on 10 August 2016

The application of non-combinatorial chemistry to lead discovery.

scientific article

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