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List of works by Patrick E. Macdonald

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes.

scientific article published on 3 May 2016

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

scientific article

A pancreatic islet-specific microRNA regulates insulin secretion

scientific article

A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets

scientific article published on 12 January 2018

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

scientific article published on 01 October 2019

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

scientific article published on 22 September 2015

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

scientific article published on 16 October 2003

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice.

scientific article published on 18 November 2015

Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.

scientific article

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

scientific article published on 29 November 2005

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats

scientific article published on 19 November 2016

Control of secretory granule access to the plasma membrane by PI3 kinase-γ ⬇️

scientific article published on November 1, 2009

Controlling insulin secretion: an exciting TASK

scientific article published on 01 October 2014

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

scientific article published on 12 February 2017

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

scientific article published on 12 February 2007

Cystic fibrosis-related diabetes is caused by islet loss and inflammation

scientific article published on 19 April 2018

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

scientific article

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

scientific article published on July 2014

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells

scientific article published on 09 April 2013

Functional plasticity of the human infant β-cell exocytotic phenotype.

scientific article

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

scientific article published on 01 February 2020

Glucagon secretion and signaling in the development of diabetes

scientific article published on 4 September 2012

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

scientific article published in May 1999

Glucose-sensing mechanisms in pancreatic beta-cells.

scientific article

Human islet function following 20 years of cryogenic biobanking

scientific article published on May 2015

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

scientific article

Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.

scientific article published on 15 March 2017

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

scientific article

Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion

scientific article published on 01 April 2020

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking

scientific article

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

scientific article published on 20 September 2002

Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

scientific article

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

scientific article

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

scientific article published on 24 September 2013

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

scientific article published on 4 February 2008

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

scientific article

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

scientific article published on 12 June 2017

LKB1 couples glucose metabolism to insulin secretion in mice.

scientific article published on 16 April 2015

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

scientific article published on 6 November 2017

Metabolomics applied to islet nutrient sensing mechanisms ⬇️

scientific article

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

scientific article

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

scientific article published on 07 September 2020

Multivesicular exocytosis in rat pancreatic beta cells.

scientific article

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

scientific article published on 09 April 2012

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

scientific article

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

scientific article published in July 1999

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

scientific article published on 11 May 2016

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.

scientific article published on 17 February 2011

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

scientific article published on March 2005

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

scientific article

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

scientific article published on 11 December 2015

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

scientific article

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

scientific article published on 10 June 2015

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

scientific article

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells

scientific article published on 06 June 2014

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

scientific article published on 21 March 2017

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

scientific article

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability

scientific article

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. ⬇️

scientific article published on 24 January 2011

Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells ⬇️

scientific article published on September 20, 2011

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

scientific article published on 6 November 2014

TRP-ing Down the Path to Insulin Secretion ⬇️

scientific article published on January 1, 2011

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

scientific article

The cell biology of systemic insulin function.

scientific article published on 5 April 2018

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

scientific article published on April 2007

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

scientific article

Toward Connecting Metabolism to the Exocytotic Site.

scientific article published on 5 December 2016

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

scientific article

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

scientific article

Triton X-100 inhibits L-type voltage-operated calcium channels ⬇️

scientific article published on January 15, 2013

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

scientific article published on 27 July 2018

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

scientific article published on 15 August 2016

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

scientific article published on 6 May 2010

cAMP-independent effects of GLP-1 on β cells.

scientific article published on 16 November 2015

β Cell tone is defined by proglucagon peptides through cAMP signaling

scientific article published on 07 March 2019

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