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List of works by Josephine Ko

A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma.

scientific article published on 5 March 2015

Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis

scientific article

Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma.

scientific article published on 27 October 2014

BRCA2 loss-of-function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese

scientific article published on 26 August 2019

Catalytic activity of Matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma.

scientific article published on April 2011

Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation

scientific article published in December 2018

Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma

scientific article

Clinical Outcome-Related Mutational Signatures Identified by Integrative Genomic Analysis in Nasopharyngeal Carcinoma

scientific article published on 28 September 2020

Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma

scientific article published on 06 May 2020

Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma.

scientific article published on 29 April 2015

Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis

scientific article

DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by downregulating the EGFR/AKT pathway in esophageal squamous cell carcinoma

scientific article published on 9 February 2016

Deciphering the molecular genetic basis of NPC through functional approaches.

scientific article published on 02 December 2011

Elevated levels of serum nidogen-2 in esophageal squamous cell carcinoma.

scientific article published on 15 December 2017

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

scientific article published in Nature Communications

Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis

scientific article

Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma.

scientific article published in November 2004

Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas

scientific article published on 01 September 2001

Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.

scientific article published on 8 March 2006

Functional evidence of decreased tumorigenicity associated with monochromosome transfer of chromosome 14 in esophageal cancer and the mapping of tumor-suppressive regions to 14q32.

scientific article

Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma.

scientific article published in August 1999

Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9

scientific article

Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma.

scientific article published on 29 May 2014

Ki-ras codon 12 point mutational activation in Hong Kong colorectal carcinoma patients

scientific article published on 01 December 1998

L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients

scientific article published on 01 March 1999

LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma.

scientific article

Leukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese

scientific article published on 07 August 2018

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma

scientific article published on 25 October 2016

Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma

scientific article

Monochromosome transfer provides functional evidence for growth-suppressive genes on chromosome 14 in nasopharyngeal carcinoma

scientific article published on August 2003

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

scientific article published on 11 December 2020

Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.

scientific article published on 21 August 2015

PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma.

scientific article

Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma

scientific article

Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015: Yogyakarta, Indonesia. 4-6 June 2015.

scientific article published on 13 April 2016

SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma

scientific article (publication date: 12 February 2015)

Succinct workflows for circulating tumor cells after enrichment: From systematic counting to mutational profiling

scientific article

The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma

scientific article

The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma

scientific article

Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.

scientific article

Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype

scientific article published on 20 April 2011

Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma

scientific article published on 7 March 2016

Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.

scientific article published on 19 September 2016

Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma

scientific article published on 13 June 2017

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