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List of works by Jörg Lippert

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

scientific article published on 24 February 2011

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.

scientific article published on 12 December 2017

A mechanistic, model-based approach to safety assessment in clinical development

scientific article

A physiological model for the estimation of the fraction dose absorbed in humans.

scientific article

Analysis of nifedipine absorption from soft gelatin capsules using PBPK modeling and biorelevant dissolution testing.

scientific article published in June 2010

Application of Physiologically-Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

scientific article published on 07 August 2019

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

scientific article published on 21 September 2016

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban-an oral, direct Factor Xa inhibitor.

scientific article published on 7 November 2014

Development of a Physiologically Based Computational Kidney Model to Describe the Renal Excretion of Hydrophilic Agents in Rats ⬇️

scientific article published on January 24, 2013

Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data

scientific article

Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban.

scientific article published on January 2014

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

scientific article published on 13 March 2007

Disparity tuning as simulated by a neural net.

scientific article published in July 2000

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

scientific article published on 23 October 2018

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation

scientific article

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: extension to describe performance of solid dosage forms

scientific article published on 28 November 2011

Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation

scientific article published on 14 March 2016

Integrating cellular metabolism into a multiscale whole-body model

scientific article

Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®.

scientific article published on 16 May 2012

Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs.

scientific article published on 8 June 2010

Modeling and Simulation of In Vivo Drug Effects.

scientific article

Multiscale Mechanistic Modeling in Pharmaceutical Research and Development ⬇️

scientific article published on January 1, 2012

On transferring the grid technology to the biomedical community

scientific article published on 01 January 2010

Pharmacogenomics of codeine, morphine, and morphine-6-glucuronide: model-based analysis of the influence of CYP2D6 activity, UGT2B7 activity, renal impairment, and CYP3A4 inhibition

scientific article published on February 1, 2012

Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study

scientific article published on 04 December 2018

Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.

scientific article

Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.

scientific article published on 26 July 2011

Predictive Pediatric Modeling and Simulation Using Ontogeny Information

scientific article published on 01 September 2019

Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach

scientific article published on 13 February 2019

Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

scientific article published on 26 August 2009

Robust PBPK/PD-Based Model Predictive Control of Blood Glucose

scientific article published on 2 November 2015

Smart Medical Information Technology for Healthcare (SMITH)

article

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.

scientific article published on 11 April 2013

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