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List of works by Samuel Waxman

12-O-tetradecanoyl-phorbol-13-acetate release of glycosyltransferases from human blood cells

scientific article published on June 1980

A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.

scientific article

A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis ⬇️

scientific article published on October 1, 2003

Advances in the management of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide

scientific article

Aggravation or Initiation of Megaloblastosis by Amino Acids in the Diet ⬇️

scientific article published on October 5, 1970

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

scholarly article

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations

scientific article

Appearance of C-type virus-like particles after co-cultivation of a human tumor-cell line with rat (XC) cells ⬇️

scientific article published on September 15, 1975

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

scientific article published on January 1998

Arsenic trioxide in multiple myeloma: rationale and future directions

scientific article

Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment.

scientific article

Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway

scientific article

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

scientific article

Benzodithiophenes induce differentiation and apoptosis in human leukemia cells

scientific article published in September 2005

Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regu

scientific article

Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models

scientific article

Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response

scientific article published on 3 February 2011

Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells

scientific article

Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors

scientific article published in December 2006

CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts ⬇️

scientific article published on August 16, 2012

Characterization of sialyltransferase activity from human placenta

scientific article published on February 1978

Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes

scientific article

Combination of cytotoxic-differentiation therapy with 5-fluorouracil and phenylbutyrate in patients with advanced colorectal cancer.

scientific article published in March 2007

Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model

scientific article published on September 2006

DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia

scientific article published on 9 November 2007

De-regulation of common housekeeping genes in hepatocellular carcinoma

scientific article (publication date: 18 July 2007)

Defective expression of cellular retinol binding protein type I and retinoic acid receptors alpha2, beta2, and gamma2 in human breast cancer cells

scientific article published on July 1996

Derepression in the desert: the third workshop on clinical translation of epigenetics in cancer therapeutics

scientific article

Differentiation therapy of acute myeloid leukemia: past, present and future

scientific article published on March 2009

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

scientific article published on March 2015

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

scientific article published on May 1999

Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells ⬇️

scientific article published on July 3, 2012

Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization

scientific article

Dual effects of glutathione-S-transferase pi on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis

scientific article published in May 2004

Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells

scientific article (publication date: 15 December 1987)

Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4.

scientific article published on February 1995

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

scientific article published on 2 March 2016

Ethacrynic Acid and a Derivative Enhance Apoptosis in Arsenic Trioxide–Treated Myeloid Leukemia and Lymphoma Cells: The Role of Glutathione S-Transferase P1-1 ⬇️

scientific article published on October 18, 2012

Evolutionary significance of persistence of latent oncogenic virus information in vertebrates

scientific article published on May 1973

Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain

scientific article

Fibrolamellar Carcinoma: A Review with Focus on Genetics and Comparison to Other Malignant Primary Liver Tumors ⬇️

scientific article published on February 22, 2011

Focal gains of VEGFA and molecular classification of hepatocellular carcinoma

scientific article published on August 2008

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

scientific article

Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

scientific article published on April 2007

Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene

scientific article

Genomic structure of the human PLZF gene

scientific article (publication date: 5 August 1999)

Glutathione-S-transferase pi inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism

scientific article

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

scientific article published on 14 June 2017

In vitro and in vivo growth and casein gene expression of mouse mammary tumor epithelial cells in response to hormones

scientific article published on 01 February 1990

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells

scientific article published in July 1994

Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis

scientific article

Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells ⬇️

scientific article published on May 1, 1988

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes

scientific article published on 4 January 2013

Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells

scientific article

JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells

scientific article

LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling

scientific article

Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors

scientific article

Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

scientific article

Lineage restriction of the RARalpha gene expression in myeloid differentiation

scientific article

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

scholarly article

Measurement of red cell folate levels by 3H-pteroylglutamic acid (3H-PteGlu) radioassay

scientific article published on 01 August 1974

Mechanisms of action of arsenic trioxide.

scientific article

Meeting report: the 11th International Conference on Differentiation Therapy and Innovative Therapeutics in Oncology

scientific article published on 9 November 2007

Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.

scientific article published on December 2003

Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells.

scientific article published on April 2003

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a

scientific article published on 13 February 2011

Modified phosphoribosylpyrophosphate (PRPP) radioenzymatic assay: increased sensitivity, technical simplification and new applications

scientific article published on 01 May 1987

Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons

scientific article published on 01 January 1992

Molecular target-based treatment of human cancer: summary of the 10th international conference on differentiation therapy

scientific article published in February 2005

Ongoing activity in peripheral nerve: injury discharge

scientific article published on 01 December 1974

PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

scientific article

Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism

scientific article (publication date: October 1987)

Pivotal role of mTOR signaling in hepatocellular carcinoma

scientific article published on 20 August 2008

RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell

scientific article

Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation

scientific article published on February 2004

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia

scientific article

Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia ⬇️

scientific article published on April 15, 1998

Reduction in lactate accumulation correlates with differentiation-induced terminal cell division of leukemia cells* ⬇️

scientific article published on September 1, 1991

Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters

scientific article published on 26 May 2008

Retinoic acid receptor alpha2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells

scientific article published in August 2002

Schizophrenia, epilepsy, cancer, methionine, and folate metabolism. Pathogenesis of schizophrenia ⬇️

scientific article published on July 5, 1975

Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

scientific article

Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells

scientific article published on 12 October 2015

Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients

scientific article

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk

scientific article published in February 2002

Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

scientific article

Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3.

scientific article

Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide

scientific article

Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells

scientific article published on 19 August 2016

Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia

scientific article published on August 2002

Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer

scientific article published on 9 October 2015

Targeting the ubiquitin-proteasome pathway in cancer therapy

scientific article published on May 2007

The 12th international conference on differentiation therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells ⬇️

scientific article published on January 7, 2011

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

scientific article published on 21 December 2007

The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis ⬇️

scientific article published on September 1, 1998

The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells

scientific article

The design of selective and non-selective combination therapy for acute promyelocytic leukemia

scientific article published on January 2007

The histone deacetylase 9 gene encodes multiple protein isoforms

scientific article

Translocations of the RARalpha gene in acute promyelocytic leukemia

scientific article

Unique genomic profile of fibrolamellar hepatocellular carcinoma

scientific article

Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

scientific article published on June 2006

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells

scientific article

Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy

scientific article

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