Search filters

List of works by Lubo Zhang

5-HT2 receptor-stimulated calcium influx in ovine uterine artery in late pregnancy

scientific article published on 01 March 1991

A novel rodent model of pregnancy complications associated with genetically determined angiotensin converting enzyme (ACE) activity

scientific article published on 23 January 2018

Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon

scientific article published on March 1, 1992

Adaptation of Pharmacomechanical Coupling of Vascular Smooth Muscle to Chronic Hypoxia ⬇️

scientific article published on March 1, 1998

Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy.

scientific article published on 9 September 2004

Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC.

scientific article published on 21 January 2005

Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.

scientific article

Amination of nitroazoles--a comparative study of structural and energetic properties.

scientific article

Angiogenesis during pregnancy: all routes lead to MAPKs.

scientific article published on 17 May 2017

Angiotensin II receptors and drug discovery in cardiovascular disease ⬇️

scientific article published on December 13, 2010

Angiotensin-converting enzymes and drug discovery in cardiovascular diseases.

scientific article

Antenatal Antioxidant Prevents Nicotine-Mediated Hypertensive Response in Rat Adult Offspring

scientific article

Antenatal Hypoxia and Programming of Glucocorticoid Receptor Expression in the Adult Rat Heart

scientific article published on 02 April 2019

Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart

scientific article published on 9 January 2016

Antenatal hypoxia induces programming of reduced arterial blood pressure response in female rat offspring: role of ovarian function.

scientific article

Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state

scientific article published on 31 October 2013

Brain-immune interactions in perinatal hypoxic-ischemic brain injury.

scientific article

C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.

scientific article published on 5 March 2018

Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair

scientific article published on 15 November 2020

Central Angiotensin I Increases Swallowing Activity and Oxytocin Release in the Near-Term Ovine Fetus ⬇️

scientific article published on November 11, 2011

Characterization of an animal model of pregnancy-induced vitamin D deficiency due to metabolic gene dysregulation.

scientific article

Chronic Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys.

scientific article published on 20 September 2017

Chronic Losartan Treatment Up-Regulates AT1R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats

scientific article published on 13 July 2015

Chronic hypoxia alters the function of NOS nerves in cerebral arteries of near-term fetal and adult sheep.

scientific article published on 25 October 2002

Chronic hypoxia during gestation enhances uterine arterial myogenic tone via heightened oxidative stress

scientific article

Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.

scientific article published on 17 April 2009

Chronic hypoxia inhibits pregnancy-induced upregulation of SKCa channel expression and function in uterine arteries.

scientific article published on 28 May 2013

Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy.

scientific article

Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in ovine uterine arteries.

scientific article published in February 2017

Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases

scientific article published on 04 September 2019

Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways.

scientific article published on 13 September 2004

Computational Modeling Approach in Probing the Effects of Cytosine Methylation on the Transcription Factor Binding to DNA.

scientific article published on 16 November 2016

Corticosteroids and perinatal hypoxic-ischemic brain injury

scientific article published on 17 May 2018

Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia.

scientific article published on 9 October 2003

Developmental Changes in the Calcium Sensitivity of Rabbit Cranial Arteries ⬇️

scientific article published on January 1, 1998

Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in ovine basilar artery ⬇️

scientific article published on December 1, 2001

Developmental nicotine exposure results in programming of alveolar simplification and interstitial pulmonary fibrosis in adult male rats.

scientific article

Dexamethasone Induces Cardiomyocyte Terminal Differentiation via Epigenetic Repression of Cyclin D2 Gene

scientific article published on 14 June 2016

Dexamethasone Treatment of Newborn Rats Decreases Cardiomyocyte Endowment in the Developing Heart through Epigenetic Modifications

scientific article published on 29 April 2015

Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway.

scientific article

Differential expression of microRNAs in ischemic heart disease.

scientific article

Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of protein kinase c/extracellular signal-regulated kinase 1/2.

scientific article published on 15 June 2009

Direct effect of chronic hypoxia in suppressing large conductance Ca(2+)-activated K(+) channel activity in ovine uterine arteries via increasing oxidative stress.

scientific article

Direct effects of nicotine on contractility of the uterine artery in pregnancy

scientific article published on 02 April 2007

EDITORIAL: Medicinal Chemistry of Molecular and Epigenetic Targets and Dug Development

scientific article published on 01 January 2017

ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy ⬇️

scientific article published on January 1, 2002

Early Detection of Coronary Artery Disease by Micro-RNA Analysis in Asymptomatic Patients Stratified by Coronary CT Angiography

scientific article published on 28 October 2020

Effect of Oxidative Stress on the Estrogen-NOS-NO-K Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications

scientific article published on 10 February 2019

Effect of cGMP on pharmacomechanical coupling in the uterine artery of near-term pregnant sheep.

scientific article published on 05 August 2008

Effect of chronic hypoxia on adrenoceptor responses of ovine foetal umbilical vessels

scientific article

Effect of chronic hypoxia on alpha-1 adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine artery.

scientific article published on March 1999

Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart ⬇️

scientific article published on May 15, 2003

Effects of chronic hypoxia on Ca2+mobilization and Ca2+sensitivity of myofilaments in uterine arteries ⬇️

scientific article published on January 1, 1998

Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries ⬇️

scientific article published on September 1, 1998

Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity.

scientific article published on 4 August 2015

Endothelial nitric oxide release in isolated perfused ovine uterine arteries: effect of pregnancy

scientific article published on 01 February 1999

Endothelin-1 promotes cardiomyocyte terminal differentiation in the developing heart via heightened DNA methylation.

scientific article published on 20 February 2014

Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery

scientific article published on March 1, 1998

Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life

scientific article published on 31 January 2019

Epigenetic mechanisms in developmental programming of adult disease.

scientific article published on 16 September 2011

Epigenetic mechanisms in heart development and disease

scientific article

Epigenetic programming of hypoxic-ischemic encephalopathy in response to fetal hypoxia

scientific article

Epigenetic upregulation of large-conductance Ca2+-activated K+ channel expression in uterine vascular adaptation to pregnancy ⬇️

scientific article

Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats.

scientific article

Estrogen normalizes perinatal nicotine-induced hypertensive responses in adult female rat offspring.

scientific article published on 25 March 2013

Fetal Hypoxia Impacts Methylome and Transcriptome in Developmental Programming of Heart Disease

scientific article published on 01 July 2019

Fetal Hypoxia Impacts on Proliferation and Differentiation of Sca-1+ Cardiac Progenitor Cells and Maturation of Cardiomyocytes: A Role of MicroRNA-210

scientific article published on 20 March 2020

Fetal and adult cerebral artery K(ATP) and K(Ca) channel responses to long-term hypoxia.

scientific article published in April 2002

Fetal hypoxia and programming of matrix metalloproteinases.

scientific article published on 18 September 2011

Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors.

scientific article published on 07 February 2014

Fetal hypoxia results in programming of aberrant angiotensin ii receptor expression patterns and kidney development

scientific article published on 13 March 2013

Fetal origins of adult disease

scientific article published on 01 January 2003

Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions

scientific article

Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats ⬇️

scientific article

Foetal hypoxia increases cardiac AT(2)R expression and subsequent vulnerability to adult ischaemic injury.

scientific article

Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells

scientific article

Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia

scientific article published on 01 August 1998

Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.

scientific article published on 11 August 2005

Gestational Hypoxia and Developmental Plasticity

scientific article published on 01 July 2018

Gestational hypoxia and epigenetic programming of brain development disorders.

scientific article

Gestational hypoxia increases reactive oxygen species and inhibits steroid hormone-mediated upregulation of Ca(2+)-activated K(+) channel function in uterine arteries

scientific article

Gestational hypoxia up-regulates protein kinase C and inhibits calcium-activated potassium channels in ovine uterine arteries.

scientific article

Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury.

scientific article

Glucocorticoids Protect Neonatal Rat Brain in Model of Hypoxic-Ischemic Encephalopathy (HIE).

scientific article published on 22 December 2016

Glucocorticoids and programming of the microenvironment in heart

scientific article published on 01 July 2019

Glucocorticoids and vascular reactivity

scientific article published on 01 January 2004

High-salt diets during pregnancy affected fetal and offspring renal renin-angiotensin system

scientific article published on June 2013

Hypoxia Represses ER-α Expression and Inhibits Estrogen-Induced Regulation of Ca2+-Activated K+ Channel Activity and Myogenic Tone in Ovine Uterine Arteries: Causal Role of DNA Methylation

scientific article published on 18 May 2015

Hypoxia and fetal heart development.

scientific article

Hypoxia inhibits cardiomyocyte proliferation in fetal rat hearts via upregulating TIMP-4

scientific article published on 20 February 2013

Hypoxia-derived oxidative stress mediates epigenetic repression of PKCɛ gene in foetal rat hearts ⬇️

scientific article published on December 2, 2011

Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood

scientific article published on 16 June 2016

Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats.

scientific article published on January 2017

Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats.

scientific article published on 11 February 2016

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice.

scientific article published on 27 October 2017

Ins(1,4,5)P3 receptors in cerebral arteries: changes with development and high-altitude hypoxia ⬇️

scientific article published on June 1, 1997

L-type Ca2+channels in fetal and adult ovine cerebral arteries ⬇️

scientific article published on January 1, 2002

Long-Term High Altitude Hypoxia influences Pulmonary Arterial L-type Calcium Channel mediated Ca(2+) signals and Contraction in Fetal and Adult Sheep.

scientific article published on 22 November 2017

Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep

scientific article published on 28 August 2019

Long-term high altitude hypoxia during gestation suppresses large conductance Ca -activated K channel function in uterine arteries: a causal role for microRNA-210

scientific article published on 01 July 2018

Long-term hypoxia alters calcium regulation in near-term ovine myometrium.

scientific article published on 25 February 2004

Long-term hypoxia uncouples Ca and eNOS in bradykinin-mediated pulmonary arterial relaxation

scientific article published on 07 March 2018

Low doses of nicotine-induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses

scientific article

Maturation Alters the Contractile Role of Calcium in Ovine Basilar Arteries ⬇️

scientific article published on August 1, 1998

Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility.

scientific article

Mechanisms and therapeutic potential of microRNAs in hypertension.

scientific article

Mechanisms of platelet-induced angiospastic reactions: potentiation of calcium sensitivity

scientific article published on 01 July 1997

MiR210 in neonatal hypoxic-ischemic encephalopathy.

scientific article published on 20 January 2017

MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy

scientific article published on 12 July 2019

MicroRNA-210 Downregulates ISCU and Induces Mitochondrial Dysfunction and Neuronal Death in Neonatal Hypoxic-Ischemic Brain Injury

scientific article published on 17 January 2019

MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury.

scientific article

MicroRNA-210 Targets Ten-Eleven Translocation Methylcytosine Dioxygenase 1 and Suppresses Pregnancy-Mediated Adaptation of Large Conductance Ca2+-Activated K+ Channel Expression and Function in Ovine Uterine Arteries.

scientific article

MicroRNA-210 suppresses glucocorticoid receptor expression in response to hypoxia in fetal rat cardiomyocytes

scientific article published on 11 May 2017

MicroRNAs in Uteroplacental Vascular Dysfunction

scientific article published on 29 October 2019

MicroRNAs in brain development and cerebrovascular pathophysiology

scientific article published on 06 March 2019

Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways ⬇️

scientific article published on 01 December 1991

Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart

scientific article published on 22 November 2006

Negative-feedback regulation of excitation-contraction coupling in gastric smooth muscle

scientific article published on December 1, 1992

Neural stem cell therapies and hypoxic-ischemic brain injury.

scientific article

Newborn hypoxia/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart: role of endothelin-1.

scientific article

Nitric oxide inhibits ACTH-induced cortisol production in near-term, long-term hypoxic ovine fetal adrenocortical cells

scientific article

Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts by activating Nox1-dependent reactive oxygen species production.

scientific article

PKC regulates alpha(1)-adrenoceptor-mediated contractions and baseline Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia.

scientific article

PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries.

scientific article published in July 2005

Perinatal nicotine exposure alters Akt/GSK-3β/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain

scientific article published on 25 September 2019

Perinatal nicotine exposure increases angiotensin II receptor-mediated vascular contractility in adult offspring.

scientific article

Postnatal maturation attenuates pressure-evoked myogenic tone and stretch-induced increases in Ca2+ in rat cerebral arteries

scientific article published on 06 June 2007

Potassium channels and uterine vascular adaptation to pregnancy and chronic hypoxia.

scientific article

Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries.

scientific article

Pregnancy Increases Ca2+ Sparks/Spontaneous Transient Outward Currents and Reduces Uterine Arterial Myogenic Tone

scientific article published on 01 March 2019

Pregnancy Reprograms Large-Conductance Ca2+-Activated K+ Channel in Uterine Arteries: Roles of Ten-Eleven Translocation Methylcytosine Dioxygenase 1-Mediated Active Demethylation.

scientific article published on 10 April 2017

Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway.

scientific article published on 6 January 2006

Pregnancy downregulates actin polymerization and pressure-dependent myogenic tone in ovine uterine arteries.

scientific article

Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring

scientific article published on 20 April 2009

Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses

scientific article

Prenatal hypoxia-induced epigenomic and transcriptomic reprogramming in rat fetal and adult offspring hearts

scientific article published on 29 October 2019

Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring.

scientific article published on 18 October 2007

Promoter methylation of Egr-1 site contributes to fetal hypoxia-mediated PKCε gene repression in the developing heart

scientific article published on 20 February 2013

Promoter methylation represses AT2R gene and increases brain hypoxic-ischemic injury in neonatal rats

scientific article published on 24 August 2013

Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring

scientific article

Regulation of Ca2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age.

scientific article published in September 1998

Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy.

scientific article published on 24 February 2006

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice

scientific article published on 17 August 2018

Repression of the Glucocorticoid Receptor Increases Hypoxic-Ischemic Brain Injury in the Male Neonatal Rat

scientific article published on 16 July 2019

Role of Ca(2+) channels in NE-induced increase in [Ca(2+)](i) and tension in fetal and adult cerebral arteries.

scientific article published on July 1999

Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring

scientific article published on 10 August 2017

Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia.

scientific article

Role of endothelin in uteroplacental circulation and fetal vascular function

scientific article

Roles of ion channels in regulation of acetylcholine-mediated vasoconstrictions in umbilical cords of rabbit/rats

scientific article published on 12 July 2016

SIRT1 increases cardiomyocyte binucleation in the heart development.

scientific article published on 3 January 2018

Short- and long-term adverse effects of cocaine abuse during pregnancy on the heart development.

scientific article published on February 2009

Suppression of myometrial contractile responses to oxytocin after different durations of chronic hypoxia in the near-term pregnant rat ⬇️

scientific article published on 01 September 1997

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

scientific article published on 22 June 2022

Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain.

scientific article published on 17 October 2008

Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia.

scientific article published on 23 April 2016

Uteroplacental circulation and maternal/fetal health..

scientific article published in September 2013

microRNAs and cardiac stem cells in heart development and disease

scientific article published on 28 May 2018

Paulina is supported by:

About Paulina

Help