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List of works by Philip Martin Leonard

A new regulatory switch in a JAK protein kinase ⬇️

scientific article published on February 1, 2011

Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment

scientific article

Crystallization and quaternary structure analysis of an Lrp-like regulatory protein from the hyperthermophile Pyrococcus furiosus

scientific article published on 25 May 2001

Crystallization of RusA Holliday junction resolvase from Escherichia coli.

scientific article published on 27 November 2003

Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease

scientific article

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor

scientific article published on 13 November 2018

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template

scientific article

Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6)

scientific article

Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.

scientific article

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

scientific article

Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.

scientific article published on 10 December 2015

Structural characterization of a beta-diketone hydrolase from the cyanobacterium Anabaena sp. PCC 7120 in native and product-bound forms, a coenzyme A-independent member of the crotonase suprafamily

scientific article

Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog

scientific article

Structure of mouse IP-10, a chemokine

scientific article

The 1.8 A resolution structure of hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens, an enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin.

scientific article published on 23 November 2006

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