List of works - Takeshi Ohta

4-(trans-4-Methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent.

scientific article published in December 1998

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice

scientific article published on 01 January 2019

Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats

scientific article published on 16 January 2020

Antidiabetic effect of chronic administration of JTT-608, a new hypoglycemic agent, in diabetic Goto-Kakizaki rats.

scientific article published in August 2003

Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.

scientific article published in December 2017

Association of a single nucleotide polymorphism in akirin 2 gene with marbling in Japanese Black beef cattle.

scientific article published on 14 July 2009

Association of a single-nucleotide polymorphism in myosin-binding protein C, slow-type (MYBPC1) gene with marbling in Japanese Black beef cattle.

scientific article

Association of expression levels in skeletal muscle and a SNP in the MYBPC1 gene with growth-related trait in Japanese Black beef cattle

scientific article published on 01 March 2015

Association of the expression levels in the longissimus muscle and a SNP in the CDC10 gene with marbling in Japanese Black beef cattle.

scientific article published on 21 May 2015

Blood pressure characteristics of female spontaneously diabetic Torii-Lepr(fa) rats.

scientific article published on 26 November 2010

Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats

scientific article published on 27 October 2011

Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats.

scientific article

Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats

scientific article published on 30 August 2019

Combination therapy of an intestine-specific inhibitor of microsomal triglyceride transfer protein and peroxisome proliferator-activated receptor γ agonist in diabetic rat

scientific article published on 17 March 2014

Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin

scientific article published on 22 January 2015

Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats

scientific article published on 29 January 2020

Daily inhibition of postprandial hyperglycaemia with JTT-608, a novel oral antidiabetic agent, ameliorates pancreatic function in neonatally streptozotocin-treated rats.

scientific article published in September 2005

Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus

scientific article published on 14 May 2018

Diabetic complications in obese type 2 diabetic rat models

scientific article

Diabetic macular edema-like ocular lesions in male spontaneously diabetic torii fatty rats

scientific article published on 12 March 2018

Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats

scientific article published on 31 July 2012

Distribution of allele frequencies at TTN g.231054C > T, RPL27A g.3109537C > T and AKIRIN2 c.*188G > A between Japanese Black and four other cattle breeds with differing historical selection for marbling.

scientific article

Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.

scientific article published on 19 August 2009

Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats

scientific article published on 01 October 2007

Effects of food restriction on pancreatic islets in Spontaneously Diabetic Torii fatty rats.

scientific article

Effects of ovariectomy on bone metabolism and bone mineral density in spontaneously diabetic Torii-Lepr(fa) rats.

scientific article published on 14 April 2011

Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model

scientific article

Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats.

scientific article published in February 2018

Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in spontaneously diabetic Torii rats.

scientific article published on 9 September 2014

Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats

scientific article published on 01 January 2010

Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

scientific article

Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats

scientific article

Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat

scientific article

Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model

scientific article published on 02 September 2018

Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat.

scientific article published on 27 October 2016

Identification of genes showing differential expression profile associated with growth rate in skeletal muscle tissue of Landrace weanling pig.

scientific article published in June 2016

Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat

scientific article published on 19 April 2007

Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.

scientific article

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats

scientific article published on 26 January 2018

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.

scientific article published on 19 October 2017

JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis

scientific article published on 2 July 2015

JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity

scientific article

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats.

scientific article

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models.

scientific article published on 20 October 2015

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats

scientific article published on 7 May 2014

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, reduces food preference for fat.

scientific article

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner

scientific article published on 07 December 2010

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats

scientific article published on 21 January 2011

JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice

scientific article published on 29 August 2015

JTT-608 restores impaired early insulin secretion in diabetic Goto-Kakizaki rats.

scientific article published in April 1999

Maternal high-fat diet promotes onset of diabetes in rat offspring

scientific article

Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats

scientific article published on 22 November 2014

Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic ToriiLeprfaRat: A New Obese Type 2 Diabetic Model ⬇️

scientific article published on February 25, 2013

Ocular inflammation in uveal tract in aged obese type 2 diabetic rats (Spontaneously Diabetic Torii fatty rats)

scientific article

Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.

scientific article published in July 2009

Parathyroid hormone (1-34) improves bone mineral density and glucose metabolism in Spontaneously Diabetic Torii-Lepr(fa) rats

scientific article published on 25 August 2011

Pathological Features of Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats

scientific article published on 15 September 2019

Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model.

scientific article

Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.

scientific article

Pathophysiological analysis of the progression of hepatic lesions in STAM mice.

scientific article published on 18 July 2017

Pathophysiological characteristics of non-alcoholic steatohepatitis-like changes in cholesterol-loaded type 2 diabetic rats

scientific article published on 10 May 2018

Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model.

scientific article published on 29 September 2017

Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol tra

scientific article published on 01 January 2015

Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice

scientific article

Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551.

scientific article published on April 2010

Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model

scientific article published on 27 February 2014

Sodium-glucose Co-transporters: Functional Properties and Pharmaceutical Potential

scientific article published on 20 March 2020

Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion

article

The G allele at the g.70014208A>G in the MYBPC1 gene associated with high marbling in Japanese Black cattle is at a low frequency in breeds not selected for marbling

scientific article published on 01 April 2014

The spontaneously diabetic torii rat: an animal model of nonobese type 2 diabetes with severe diabetic complications.

scientific article published on 26 February 2013

List of works by Takeshi Ohta

4-(trans-4-Methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent.

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice

Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats

Antidiabetic effect of chronic administration of JTT-608, a new hypoglycemic agent, in diabetic Goto-Kakizaki rats.

Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.

Association of a single nucleotide polymorphism in akirin 2 gene with marbling in Japanese Black beef cattle.

Association of a single-nucleotide polymorphism in myosin-binding protein C, slow-type (MYBPC1) gene with marbling in Japanese Black beef cattle.

Association of expression levels in skeletal muscle and a SNP in the MYBPC1 gene with growth-related trait in Japanese Black beef cattle

Association of the expression levels in the longissimus muscle and a SNP in the CDC10 gene with marbling in Japanese Black beef cattle.

Blood pressure characteristics of female spontaneously diabetic Torii-Lepr(fa) rats.

Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats

Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats.

Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats

Combination therapy of an intestine-specific inhibitor of microsomal triglyceride transfer protein and peroxisome proliferator-activated receptor γ agonist in diabetic rat

Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin

Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats

Daily inhibition of postprandial hyperglycaemia with JTT-608, a novel oral antidiabetic agent, ameliorates pancreatic function in neonatally streptozotocin-treated rats.

Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus

Diabetic complications in obese type 2 diabetic rat models

Diabetic macular edema-like ocular lesions in male spontaneously diabetic torii fatty rats

Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats

Distribution of allele frequencies at TTN g.231054C > T, RPL27A g.3109537C > T and AKIRIN2 c.*188G > A between Japanese Black and four other cattle breeds with differing historical selection for marbling.

Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.

Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats

Effects of food restriction on pancreatic islets in Spontaneously Diabetic Torii fatty rats.

Effects of ovariectomy on bone metabolism and bone mineral density in spontaneously diabetic Torii-Lepr(fa) rats.

Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model

Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats.

Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in spontaneously diabetic Torii rats.

Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats

Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats

Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat

Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model

Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat.

Identification of genes showing differential expression profile associated with growth rate in skeletal muscle tissue of Landrace weanling pig.

Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat

Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats

JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.

JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis

JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats.

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models.

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, reduces food preference for fat.

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats

JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice

JTT-608 restores impaired early insulin secretion in diabetic Goto-Kakizaki rats.

Maternal high-fat diet promotes onset of diabetes in rat offspring

Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats

Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic ToriiLeprfaRat: A New Obese Type 2 Diabetic Model ⬇️

Ocular inflammation in uveal tract in aged obese type 2 diabetic rats (Spontaneously Diabetic Torii fatty rats)

Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.

Parathyroid hormone (1-34) improves bone mineral density and glucose metabolism in Spontaneously Diabetic Torii-Lepr(fa) rats

Pathological Features of Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats

Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model.

Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.

Pathophysiological analysis of the progression of hepatic lesions in STAM mice.

Pathophysiological characteristics of non-alcoholic steatohepatitis-like changes in cholesterol-loaded type 2 diabetic rats

Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model.

Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol tra

Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice

Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551.

Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model

Sodium-glucose Co-transporters: Functional Properties and Pharmaceutical Potential

Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion

The G allele at the g.70014208A>G in the MYBPC1 gene associated with high marbling in Japanese Black cattle is at a low frequency in breeds not selected for marbling

The spontaneously diabetic torii rat: an animal model of nonobese type 2 diabetes with severe diabetic complications.