List of works - George Koukos

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

scientific article

A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.

scientific article

Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics

scientific article published in May 2015

Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice

scientific article published on 01 July 2018

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta a

scientific article published on December 2003

HDL biogenesis, remodeling, and catabolism.

scientific article

Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat

scientific article published on 29 July 2015

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

scientific article

LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.

scientific article published on 21 August 2007

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.

scientific article

Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy

scientific article published on 26 September 2018

MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.

scientific article

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice

scientific article

Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.

scientific article published on August 2007

Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.

scientific article published on 5 April 2018

Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.

scientific article

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia ⬇️

scientific article published on September 22, 2011

Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury.

scientific article published on 09 May 2011

Systems biology in inflammatory bowel diseases: ready for prime time

scientific article published on July 2014

The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.

scientific article published on 21 April 2007

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

scientific article

Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection.

scientific article published on 7 July 2017

List of works by George Koukos

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.

Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics

Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta a

HDL biogenesis, remodeling, and catabolism.

Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.

Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy

MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice

Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.

Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.

Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia ⬇️

Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury.

Systems biology in inflammatory bowel diseases: ready for prime time

The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection.