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List of works by Sibylle Neuhoff

A laboratory specific scaling factor to predict the in vivo human clearance of aldehyde oxidase substrates

scientific article published on 06 September 2020

A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine

scientific article published on January 2014

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

scientific article published on 04 August 2016

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin. ⬇️

scientific article

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.

scientific article published on 25 April 2013

Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

scientific article published on 01 February 2019

Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2.

scientific article published on 4 March 2016

Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

scientific article published on 20 January 2005

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.

scientific article published on 09 December 2016

Comment on the article "physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions"

scientific article published on 16 March 2013

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

scientific article

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

scientific article published on 4 January 2016

Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure.

scientific article

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

scientific article published in January 2006

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2

scientific article published on 02 December 2015

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

scientific article published on 3 February 2016

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

scientific article published on 15 March 2014

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

scientific article published on 19 May 2017

Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.

scientific article

Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics

scientific article published on 24 July 2014

Mass Spectrometry-Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

scientific article published on 31 October 2020

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions

scientific article published on 25 March 2016

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-Mediated Clearances.

scientific article published on July 2016

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

scientific article published on 19 June 2018

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

scientific article published on 19 October 2019

Population-based mechanistic prediction of oral drug absorption

scientific article published on 21 April 2009

Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions

scientific article published on 30 April 2019

Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport.

scientific article published on 31 March 2017

Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

scientific article published on 08 February 2019

Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach

scientific article published on 27 April 2018

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

scientific article published on 17 October 2019

The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis

scientific article published on 10 May 2019

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

scientific article published on 26 October 2018

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

scientific article published on 25 April 2013

Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

scientific article published on 21 February 2018

pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers.

scientific article published on 23 March 2005

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

scientific article published in August 2003

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