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List of works by Michael Boutros

A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.

scientific article published in October 2012

A Protocol for a High-Throughput Multiplex Cell Viability Assay

scientific article

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.

scientific article published on 23 December 2015

A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network.

scientific article

A genetic interaction map of cell cycle regulators

scientific article

A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

scientific article published on 5 April 2010

A genome-wide RNA interference screen identifies caspase 4 as a factor required for tumor necrosis factor alpha signaling.

scientific article published on 25 June 2012

A global genetic interaction network maps a wiring diagram of cellular function

scientific article

A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes

scientific article

A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila.

scientific article published on 13 October 2009

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

scientific article published on 13 February 2020

A map of directional genetic interactions in a metazoan cell

scientific article

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

scientific article

A novel phenotypic dissimilarity method for image-based high-throughput screens.

scientific article

A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

scientific article

ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration

scientific article published on 08 March 2017

Active Wnt proteins are secreted on exosomes.

scientific article

Ageing, metabolism and the intestine

scientific article published on 21 June 2020

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

scientific article published on 26 May 2015

An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.

scientific article published in October 2005

An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs

scientific article published on 26 September 2017

An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome

scientific article

Analysis of cell-based RNAi screens.

scientific article published on January 2006

Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells.

scientific article published on 10 January 2017

Biochemical Methods to Analyze Wnt Protein Secretion.

scientific article published in January 2016

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

scientific article

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.

scientific article published on 25 February 2016

Celebrating 100 years of Drosophila research.

scientific article

Cell Perturbation Screens for Target Identification by RNAi ⬇️

scientific article published on January 1, 2012

Cellular phenotyping by RNAi.

scientific article

Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn's Disease.

scientific article

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.

scientific article published on June 2010

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

scientific article published on 23 August 2012

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.

scientific article

Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker

scientific article published on 09 April 2017

Design and evaluation of genome-wide libraries for RNA interference screens

scientific article

Dpp/Gbb signaling is required for normal intestinal regeneration during infection

scientific article published on 29 December 2014

Drosophila Wnt/Fz pathways

scientific article published on 10 May 2005

DrosophilaRas/MAPK signalling regulates innate immune responses in immune and intestinal stem cells ⬇️

scientific article published on February 4, 2011

E-CRISP: fast CRISPR target site identification

scientific article published in February 2014

E-RNAi: a web application for the multi-species design of RNAi reagents--2010 update

scientific article

E-TALEN: a web tool to design TALENs for genome engineering.

scientific article published on 3 September 2013

EBImage--an R package for image processing with applications to cellular phenotypes.

scientific article published on April 2010

ERAD-dependent control of the Wnt secretory factor Evi.

scientific article

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

scientific article

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling

scientific journal article

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

scientific article published on 17 September 2019

Extracellular vesicles and oncogenic signaling

scientific article published on 18 November 2020

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi.

scientific article

FlyRNAi: the Drosophila RNAi screening center database.

scientific article

Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference

scientific article

Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening

scientific article published on 17 May 2015

Gene expression atlas of a developing tissue by single cell expression correlation analysis

scientific article published on 29 July 2019

Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.

scientific article

Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library

scientific article published on 23 November 2020

Genome-wide RNAi analysis of growth and viability in Drosophila cells

scientific article

Genome-wide RNAi as a route to gene function in Drosophila.

scientific article

GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens.

scientific article published on 26 October 2016

GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update.

scientific article

GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update.

scientific article

HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens.

scientific article

High-throughput RNA interference screens in Drosophila tissue culture cells.

scientific article

High-throughput RNAi screening to dissect cellular pathways: a how-to guide.

scientific article

Identification of JAK/STAT signalling components by genome-wide RNA interference.

scientific article

Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen.

scientific article published in March 2008

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1

scientific article

Immune cell recruitment in teratomas is impaired by increased Wnt secretion.

scientific article published on 29 October 2016

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 04 November 2020

Innate immunity: regulation of caspases by IAP-dependent ubiquitylation ⬇️

scientific article published on May 15, 2012

JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis

scientific article published on 10 April 2020

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein

scientific article

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

scientific article

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.

scientific article published on 07 June 2013

Large-scale RNAi screens to dissect TNF and NF-κB signaling pathways.

scientific article published in January 2011

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.

scientific article published on 05 August 2013

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

scientific article published on 16 May 2019

Machine learning and image-based profiling in drug discovery

scientific article published on 01 August 2018

Managing the genome: microRNAs in Drosophila.

scientific article published on March 2004

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

scientific article published on 7 April 2013

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

scientific article published on 21 July 2017

Measuring genetic interactions in human cells by RNAi and imaging

scientific article published on 11 September 2014

Methods for High-Throughput RNAi Screening in Drosophila Cells.

scientific article

Microscopy-Based High-Content Screening.

scientific article

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.

scientific article

Multiplexed conditional genome editing with Cas12a in Drosophila

scientific article published on 25 August 2020

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.

scientific article

On target: A public repository for large-scale RNAi experiments

scientific article published on 02 February 2012

Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs.

scientific article published on 19 May 2017

Phenotype databases for genetic screens in human cells.

scientific article

Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications ⬇️

scientific article published on November 25, 2010

Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset

scientific article

Proteins required for centrosome clustering in cancer cells.

scientific article

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 22 December 2020

RAB8B is required for activity and caveolar endocytosis of LRP6.

scientific article published on 12 September 2013

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.

scientific article published on 23 April 2015

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons ⬇️

scientific article published on March 24, 1995

RNA Interference (RNAi) Screening in Drosophila.

scientific article published in March 2018

RNAi screening in cultured Drosophila cells.

scientific article published in January 2008

Refining Pathways: A Model Comparison Approach

scientific article

Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling

scientific article

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing

scientific article published on 09 August 2019

Screens, maps & networks: from genome sequences to personalized medicine ⬇️

scientific article published on February 25, 2012

Secretion and extracellular space travel of Wnt proteins.

scientific article published on 26 March 2013

Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

scientific article

Sequential activation of signaling pathways during innate immune responses in Drosophila.

scientific article published on November 2002

Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.

scientific article published in September 2003

Signaling specificity by Frizzled receptors in Drosophila.

scientific article

Smed-Evi/Wntless is required for beta-catenin-dependent and -independent processes during planarian regeneration.

scientific article published on 11 February 2009

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.

scientific article

Sticking Around: Short-Range Activity of Wnt Ligands.

scientific article published in March 2016

Systematic characterization of pan-cancer mutation clusters.

scientific article published on 23 March 2018

Systematic epistatic mapping of cellular processes

scientific article published on 6 January 2017

The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling.

scientific article published on September 1999

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

scientific article

The art and design of genetic screens: RNA interference.

scientific article published on 03 June 2008

The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction

scientific article published on 3 August 2017

The drug-induced phenotypic landscape of colorectal cancer organoids

scientific article published on 06 June 2022

The head-regeneration transcriptome of the planarian Schmidtea mediterranea.

scientific article

The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance.

scientific article

The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells

scientific article

The promise and perils of Wnt signaling through beta-catenin.

scientific article

Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.

scientific article published on 28 October 2015

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

scientific article published on 28 December 2018

Toward an integrated map of genetic interactions in cancer cells.

scientific article published on 21 February 2018

Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells

scientific article published on December 2015

Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation

scientific article

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

scientific article published on January 2013

Wnt signaling in cancer.

scientific article published on 12 September 2016

Wnt signaling signaling at and above the receptor level.

scientific article published on January 2011

Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.

scientific article published on 24 June 2010

Wnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

scientific article published on 30 November 2020

caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens.

scientific article published on 27 October 2015

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

scientific article published on 07 May 2020

eIF4A inactivates TORC1 in response to amino acid starvation

scientific article published on 17 March 2016

p24 proteins are required for secretion of Wnt ligands

scientific article

web cellHTS2: a web-application for the analysis of high-throughput screening data.

scientific article

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