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List of works by George Baillie

A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins

scientific article published in Journal of Biological Chemistry

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

scientific article

A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

scientific article published on 10 May 2019

A role for APP in Wnt signalling links synapse loss with β-amyloid production

scientific article published on 20 September 2018

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex

scientific article

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase

scientific article published on 05 December 2018

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA

scientific article published on 11 April 2019

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

scientific article published on 31 March 2017

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. ⬇️

scientific article

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.

scientific article

Arrestin regulation of small GTPases

scientific article published on 01 January 2014

Arrestin-dependent localization of phosphodiesterases.

scientific article published in January 2014

Beta‐amyloid interacts with and activates the long‐form phosphodiesterase <scp>PDE4D5</scp> in neuronal cells to reduce <scp>cAMP</scp> availability

scientific article published in 2024

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

scientific article (publication date: 4 August 2015)

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

scientific article

Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

scientific article published on 23 December 2019

Compartmentalisation of second messenger signalling pathways

scientific article published on 08 May 2014

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.

scientific article published on August 2016

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

scientific article published on 23 February 2009

Cyclic AMP‐specific phosphodiesterase, PDE8A1, is activated by protein kinase A‐mediated phosphorylation ⬇️

scientific article published on May 3, 2012

Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity

scientific article published on 13 November 2014

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

scientific article

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

scientific article published on 27 December 2014

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

scholarly article

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

scientific article (publication date: 2 June 2000)

Editorial

scientific article published on 03 February 2016

Editorial: Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

scientific article published on 29 January 2016

Effect of tacrolimus on skin microbiome in atopic dermatitis

scientific article published on 11 March 2019

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

scientific article

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle

scientific article published on February 2017

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

scientific article published on 20 July 2017

George Baillie on peptide array, a technique that transformed research on phosphodiesterases

scientific article published on November 2015

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

scientific article published on 28 June 2016

Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.

scientific article

Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).

scientific article published on 6 October 2015

Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis.

scientific article published on 24 July 2014

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

scientific article

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases

scientific article published on 23 September 2016

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

scientific article

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.

scientific article

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.

scientific article

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

scientific article published on 19 December 2016

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

scientific article published on 5 August 2008

Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells.

scientific article published on 25 November 2017

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

scientific article published on 05 September 2016

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

scientific article published on 12 January 2018

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C ⬇️

scientific article published on November 15, 2010

Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?

scientific article published on 10 August 2013

Location, location, location: PDE4D5 function is directed by its unique N-terminal region.

scientific article

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

scientific article

Methods to Investigate Arrestins in Complex with Phosphodiesterases

scientific article published on 01 January 2019

Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice ⬇️

scientific article

Mixed species biofilms of Candida albicans and Staphylococcus epidermidis.

scientific article

Modelling and mathematical analysis of the M$_{2}$ receptor-dependent joint signalling and secondary messenger network in CHO cells.

scientific article

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

scientific article

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

scientific article published on 18 May 2017

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

scientific article

Non-genetic therapeutic approaches to Canavan disease.

scientific article published on 10 May 2016

PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders

scientific article published on 02 April 2019

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

scientific article

PDE4-Mediated cAMP Signalling.

scientific article published on 31 January 2018

PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex

scientific article

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

scientific article published on 7 August 2014

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

scientific article published on 27 July 2017

Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase

scientific article published on 7 September 2017

Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology

scientific article published on 12 April 2014

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

scientific article published in November 2001

Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling.

scientific article published on 4 August 2014

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

scientific article published on March 2006

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

scientific article published on 8 November 2016

Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling

scientific article published on 01 July 2019

Production of extracellular matrix by Candida albicans biofilms ⬇️

scientific article published on March 1, 1998

Protein kinase D in the hypertrophy pathway.

scientific article published on February 2012

RAB40C regulates RACK1 stability via the ubiquitin-proteasome system

scientific article published on 02 July 2018

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

scientific article published on 3 September 2016

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

scientific article published on 19 July 2005

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

scientific article

Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes

scientific article published on 01 October 2019

Role of dimorphism in the development of Candida albicans biofilms.

scientific article

SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.

scientific article published on 15 March 2016

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity

scientific article published on 5 December 2016

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.

scientific article published on 23 August 2016

Sleep deprivation impairs cAMP signalling in the hippocampus

scientific article

Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

scientific article

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

scientific article published on 17 June 2019

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition ⬇️

scientific article

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

scientific article (publication date: 2 August 2002)

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

scientific article

Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy.

scientific article published on 28 October 2014

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf

scientific article published on 25 March 2019

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

scientific article

The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser16 ⬇️

scientific article published on September 15, 2012

The Association of the Long Prostate Cancer Expressed PDE4D Transcripts to Poor Patient Outcome Depends on the Tumour's TMPRSS2-ERG Fusion Status

scientific article published on 02 June 2019

The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

scientific article published on 26 July 2018

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus

scientific article published on 11 February 2015

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

scientific article

The cardioprotective role of small heat-shock protein 20.

scientific article published on April 2014

The emerging role of HSP20 as a multifunctional protective agent ⬇️

scientific article published on May 15, 2011

The extent and the nature of the cholinergic contribution to the hepatic encephalopathy-induced cognitive impairment

scientific article published on 22 August 2013

The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death.

scientific article

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease

scientific article

Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond

scientific article published on 06 August 2019

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

scientific article

Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches

scientific article published on 01 October 2019

Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

scientific article

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

scientific article published on November 2007

cAMP: novel concepts in compartmentalised signalling.

scientific article published on 13 September 2011

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

scientific article published on 19 June 2010

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

scientific article published on 30 December 2015

β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current.

scientific article published on 23 October 2014

β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.

scientific article

β-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of β2-adrenoceptor signalling to activation of ERK

article

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