List of works - Francisco Palacios

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study

scientific article

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.

scientific article published on 9 September 2016

Asymmetric Synthesis of Functionalized Tetrasubstituted α-Aminophosphonates through Enantioselective Aza-Henry Reaction of Phosphorylated Ketimines

scientific article published on 09 December 2014

Brönsted-Acid-Catalyzed Asymmetric Three-Component Reaction of Amines, Aldehydes, and Pyruvate Derivatives. Enantioselective Synthesis of Highly Functionalized γ-Lactam Derivatives

scientific article published on 28 December 2017

Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes.

scientific article

Conjugate addition of amines to an alpha,beta-unsaturated imine derived from alpha-aminophosphonate. Synthesis of gamma-amino-alpha-dehydroaminophosphonates.

scientific article published in January 2009

Copper-catalyzed asymmetric conjugate addition of diethylzinc to alpha,beta-unsaturated imines derived from alpha-aminoacids. Enantioselective synthesis of gamma-substituted alpha-dehydroaminoesters

scientific article published on 01 November 2006

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives

scientific article published on 29 July 2010

Efficient synthesis of 1-azadienes derived from alpha-aminoesters. Regioselective preparation of alpha-dehydroamino acids, vinylglycines, and alpha-amino acids

scientific article published on 01 September 2006

Enantioselective Aza-Reformatsky Reaction with Ketimines

scientific article published on 15 November 2019

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

scientific article published on 07 January 2019

First synthesis of merged hybrids phosphorylated azirino[2,1-b]benzo[e][1,3]oxazine derivatives as anticancer agents

scientific article published on 19 October 2019

Fluoroalkyl alpha,beta-unsaturated imines. Valuable synthetic intermediates from primary fluorinated enamine phosphonates

scientific article published on 01 March 2002

Fluoroalkylated α,β-unsaturated imines as synthons for the preparation of fluorinated triazinane-2,4-diones and dihydropyrimidin-2(1H)-ones

scientific article published on 13 May 2014

Free and Supported Phosphorus Ylides as Strong Neutral Brønsted Bases

scientific article published on 01 May 1999

Hetero-Diels-Alder reaction of phosphinyl and phosphonyl nitroso alkenes with conjugated dienes: an aza-Cope rearrangement

scientific article published on 15 July 2011

Hetero-Diels-Alder reaction of phosphorylated nitroso alkenes with enol ethers on water: a clean approach toward 1,2-oxazine derivatives

scientific article published on 31 July 2014

Mechanism and stereoselectivity of the aza-Wittig reaction between phosphazenes and aldehydes

scientific article published on 01 March 2006

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams.

scientific article published on 8 May 2019

N-Phosphino- and N-Phosphonionitrilimines: From Nucleophilic to Electrophilic 1,3-Dipoles

scientific article published on 01 January 1997

New Challenges in Drug Discovery - July 8-11, 2019, Vitoria-Gasteiz, Spain

scientific article published on 19 November 2019

Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents

scientific article published on 28 May 2020

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity.

scientific article published on 22 February 2018

Reaction of 2H-Azirine-Phosphine Oxides and -Phosphonates with Enolates Derived from β-Keto Esters

scientific article published on 17 December 2015

Reaction of 2H-azirine phosphine oxide and -phosphonates with nucleophiles. Stereoselective Synthesis of functionalized aziridines and alpha- and beta-aminophosphorus derivatives.

scientific article published in October 2005

Reaction of N-vinylic phosphazenes with alpha,beta-unsaturated aldehydes. Azatriene-mediated synthesis of dihydropyridines and pyridines derived from beta-amino acids

scientific article published on 01 August 2006

Reaction of acetylenic esters and N-functionalized phosphazenes. 1,2-versus 1,4-addition of N-vinylic phosphazenes.

scientific article published in April 2003

Reaction of phosphinylated nitrosoalkenes with electron-rich heterocycles. Electrophilic aromatic substitution vs. cycloaddition.

scientific article

Reactions of conjugate phosphinyl- and phosphonyl-nitroso alkenes with enamines. Preparation of N-hydroxypyrrole derivatives.

scientific article

Recent advances of the Povarov reaction in medicinal chemistry

scientific article published on 28 August 2018

Regioselective synthesis of fluoroalkylated beta-aminophosphorus derivatives and aziridines from phosphorylated oximes and nucleophilic reagents

scientific article published on 01 August 2006

Seasonal Terpene Variation in Needles of Pinus radiata (Pinales: Pinaceae) Trees Attacked by Tomicus piniperda (Coleoptera: Scolytinae) and the Effect of Limonene on Beetle Aggregation

scientific article published in September 2017

Selective synthesis of substituted pyrrole-2-phosphine oxides and -phosphonates from 2H-azirines and enolates from acetyl acetates and malonates.

scientific article published on 28 October 2011

Selective synthesis of α-fluoro-β-keto- and α-fluoro-β-aminophosphonates via electrophilic fluorination by selectfluor

scientific article published on 18 January 2011

Simple asymmetric synthesis of 2H-azirines derived from phosphine oxides

scientific article published on 01 May 2000

Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions

scientific article published on 01 August 2006

Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones

scientific article published on 14 June 2019

Study of the Hetero-[4+2]-Cycloaddition Reaction of Aldimines and Alkynes. Synthesis of 1,5-Naphthyridine and Isoindolone Derivatives

scientific article

Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation

scientific article published on 18 April 2018

Synthesis and biological evaluation of cyanoaziridine phosphine oxides and phosphonates with antiproliferative activity

scientific article published on 03 December 2018

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

scientific article published on 14 March 2016

Synthesis of alpha-phosphorylated alpha,beta-unsaturated imines and their selective reduction to vinylogous and saturated alpha-aminophosphonates

scientific article published on 01 March 2007

Synthesis of aza polycyclic compounds derived from pyrrolidine, indolizidine, and indole via intramolecular Diels-Alder cycloadditions of neutral 2-azadienes.

scientific article published in March 2002

Synthesis of fluorinated β-aminophosphonates and γ-lactams

scientific article published on 22 March 2013

Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives

scientific article published on 15 September 2018

Synthesis of pyrazine-phosphonates and -phosphine oxides from 2H-azirines or oximes

scientific article published on 01 July 2002

The Neber approach to 2-(tetrazol-5-yl)-2H-azirines.

scientific article published on 3 July 2013

List of works by Francisco Palacios

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.

Asymmetric Synthesis of Functionalized Tetrasubstituted α-Aminophosphonates through Enantioselective Aza-Henry Reaction of Phosphorylated Ketimines

Brönsted-Acid-Catalyzed Asymmetric Three-Component Reaction of Amines, Aldehydes, and Pyruvate Derivatives. Enantioselective Synthesis of Highly Functionalized γ-Lactam Derivatives

Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes.

Conjugate addition of amines to an alpha,beta-unsaturated imine derived from alpha-aminophosphonate. Synthesis of gamma-amino-alpha-dehydroaminophosphonates.

Copper-catalyzed asymmetric conjugate addition of diethylzinc to alpha,beta-unsaturated imines derived from alpha-aminoacids. Enantioselective synthesis of gamma-substituted alpha-dehydroaminoesters

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives

Efficient synthesis of 1-azadienes derived from alpha-aminoesters. Regioselective preparation of alpha-dehydroamino acids, vinylglycines, and alpha-amino acids

Enantioselective Aza-Reformatsky Reaction with Ketimines

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

First synthesis of merged hybrids phosphorylated azirino[2,1-b]benzo[e][1,3]oxazine derivatives as anticancer agents

Fluoroalkyl alpha,beta-unsaturated imines. Valuable synthetic intermediates from primary fluorinated enamine phosphonates

Fluoroalkylated α,β-unsaturated imines as synthons for the preparation of fluorinated triazinane-2,4-diones and dihydropyrimidin-2(1H)-ones

Free and Supported Phosphorus Ylides as Strong Neutral Brønsted Bases

Hetero-Diels-Alder reaction of phosphinyl and phosphonyl nitroso alkenes with conjugated dienes: an aza-Cope rearrangement

Hetero-Diels-Alder reaction of phosphorylated nitroso alkenes with enol ethers on water: a clean approach toward 1,2-oxazine derivatives

Mechanism and stereoselectivity of the aza-Wittig reaction between phosphazenes and aldehydes

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams.

N-Phosphino- and N-Phosphonionitrilimines: From Nucleophilic to Electrophilic 1,3-Dipoles

New Challenges in Drug Discovery - July 8-11, 2019, Vitoria-Gasteiz, Spain

Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity.

Reaction of 2H-Azirine-Phosphine Oxides and -Phosphonates with Enolates Derived from β-Keto Esters

Reaction of 2H-azirine phosphine oxide and -phosphonates with nucleophiles. Stereoselective Synthesis of functionalized aziridines and alpha- and beta-aminophosphorus derivatives.

Reaction of N-vinylic phosphazenes with alpha,beta-unsaturated aldehydes. Azatriene-mediated synthesis of dihydropyridines and pyridines derived from beta-amino acids

Reaction of acetylenic esters and N-functionalized phosphazenes. 1,2-versus 1,4-addition of N-vinylic phosphazenes.

Reaction of phosphinylated nitrosoalkenes with electron-rich heterocycles. Electrophilic aromatic substitution vs. cycloaddition.

Reactions of conjugate phosphinyl- and phosphonyl-nitroso alkenes with enamines. Preparation of N-hydroxypyrrole derivatives.

Recent advances of the Povarov reaction in medicinal chemistry

Regioselective synthesis of fluoroalkylated beta-aminophosphorus derivatives and aziridines from phosphorylated oximes and nucleophilic reagents

Seasonal Terpene Variation in Needles of Pinus radiata (Pinales: Pinaceae) Trees Attacked by Tomicus piniperda (Coleoptera: Scolytinae) and the Effect of Limonene on Beetle Aggregation

Selective synthesis of substituted pyrrole-2-phosphine oxides and -phosphonates from 2H-azirines and enolates from acetyl acetates and malonates.

Selective synthesis of α-fluoro-β-keto- and α-fluoro-β-aminophosphonates via electrophilic fluorination by selectfluor

Simple asymmetric synthesis of 2H-azirines derived from phosphine oxides

Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions

Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones

Study of the Hetero-[4+2]-Cycloaddition Reaction of Aldimines and Alkynes. Synthesis of 1,5-Naphthyridine and Isoindolone Derivatives

Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation

Synthesis and biological evaluation of cyanoaziridine phosphine oxides and phosphonates with antiproliferative activity

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

Synthesis of alpha-phosphorylated alpha,beta-unsaturated imines and their selective reduction to vinylogous and saturated alpha-aminophosphonates

Synthesis of aza polycyclic compounds derived from pyrrolidine, indolizidine, and indole via intramolecular Diels-Alder cycloadditions of neutral 2-azadienes.

Synthesis of fluorinated β-aminophosphonates and γ-lactams

Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives

Synthesis of pyrazine-phosphonates and -phosphine oxides from 2H-azirines or oximes

The Neber approach to 2-(tetrazol-5-yl)-2H-azirines.