List of works by Paul R Gilson

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

scientific article published on 16 July 2019

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

scientific article

A common protein export pathway in malaria parasites

scientific article published on 20 October 2010

A model for the progression of receptor-ligand interactions during erythrocyte invasion by Plasmodium falciparum

scientific article published on 21 March 2012

A new system for rapid plasmid integration in Plasmodium parasites

scientific article published on 28 November 2006

A newly discovered protein export machine in malaria parasites

scientific article

A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role

scientific article (publication date: 11 September 2009)

Advances in molecular genetic systems in malaria

scientific article published on June 2015

An aspartyl protease directs malaria effector proteins to the host cell

scientific article

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

scientific article published on 22 April 2016

Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41

scientific article

Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

scientific article (publication date: 9 March 2012)

Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.

scientific article

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

scientific article

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites ⬇️

scientific article (publication date: May 2014)

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

scientific article published on 30 October 2017

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

scientific article published on 11 November 2016

Disrupting the allosteric interaction between the Plasmodium falciparum cAMP-dependent kinase and its regulatory subunit

scientific article

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum

scientific article (publication date: 2 December 2005)

Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion?

scientific article

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

scientific article published on 26 February 2019

Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum

scientific article published on 28 March 2016

Functional conservation of the AMA1 host-cell invasion ligand between P. falciparum and P. vivax: a novel platform to accelerate vaccine and drug development

scientific article

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

scientific article

Host cell remodelling in malaria parasites: a new pool of potential drug targets

scientific article published on 28 June 2016

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development

scientific article published on 17 June 2013

Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum

scientific article (publication date: July 2006)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

scientific article (publication date: 22 November 2016)

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts

scientific article published on 27 April 2007

Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

scientific article

Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.

scientific article

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export

scientific article published in PLoS ONE

MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking

scientific article published in April 2008

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum ⬇️

scientific article

Molecular genetic tools in Toxoplasma and Plasmodium: achievements and future needs

scientific article published on August 2007

Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites

scientific article

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

scientific article published on 12 January 2017

Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion

scientific article

PTEX is an essential nexus for protein export in malaria parasites

scientific article (publication date: 31 July 2014)

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

scholarly article by Danushka S Marapana et al published September 2018 in Nature Microbiology

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes ⬇️

scientific article

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

scientific article (publication date: 2 March 2017)

Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors

scientific article

Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte

scientific article (publication date: November 2012)

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

scientific article (publication date: 2010)

Protein export in Plasmodium parasites: from the endoplasmic reticulum to the vacuolar export machine

scientific article published on 17 February 2010

Protein export in malaria parasites: an update

scientific article published on 27 January 2014

Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite

scientific article

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

scientific article (publication date: November 2016)

Quantifying the importance of MSP1-19 as a target of growth-inhibitory and protective antibodies against Plasmodium falciparum in humans

scientific article

Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites

scientific article published on 22 October 2012

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

scientific article (publication date: February 2016)

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

scientific article (publication date: February 2015)

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

scientific article

Spatial organisation of protein export in malaria parasite blood stages.

scientific article published on 26 April 2018

Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum

scientific article

Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

scientific article

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

scientific article (publication date: September 2013)

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

scientific article published on 21 July 2017

Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

scientific article

Trafficking of the exported P. falciparum chaperone PfHsp70x

scientific article (publication date: 8 November 2016)

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