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List of works by Klaus Pors

Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer.

scientific article

Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

scientific article published on 04 December 2020

Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

scientific article published on 26 September 2014

Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

scientific article published on 12 December 2017

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

scientific article published on October 2013

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

scientific article published on January 2009

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

scientific article published on 15 April 2013

Current challenges and opportunities in treating hypoxic prostate tumors

scientific article published in March 2018

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

scientific article published in January 2022

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

scientific article published on 23 September 2021

DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

scientific article

Design and synthesis of a DNA-crosslinking azinomycin analogue.

scientific article published on 5 September 2005

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

scientific article published on 23 September 2021

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

scientific article published on October 2005

Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

scientific article published on 26 February 2024

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

scientific article published on 27 June 2019

Expression and regulation of aldehyde dehydrogenases in prostate cancer

scientific article published on 21 August 2018

How can the potential of the duocarmycins be unlocked for cancer therapy?

scientific article published on 21 November 2020

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

scientific article

Insight into the Liposomal Encapsulation of Mono and Bis-Naphthalimides

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

scientific article published on 12 March 2021

Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?

scientific article

Microtubule stabilising agents for cancer chemotherapy.

scientific article published on May 2009

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

scientific article published in March 2012

Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.

scientific article

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

scientific article published on 14 October 2011

Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties

scientific article published on 23 October 2019

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

scientific article published on 9 September 2016

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

scientific article published on 16 March 2018

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

scientific article published in June 2021

Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones.

scientific article published on 16 March 2018

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

scientific article published in 2015

Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay

scientific article published on 14 July 2014

Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450

scientific article published on 06 May 2016

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

scientific article published on 07 May 2015

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

scientific article published on 30 September 2015

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

scientific article

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

scientific article

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.

scientific article published on March 2004

Synthesis and biological properties of aryl methyl sulfones

scientific article published on 30 June 2018

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

scientific article published on November 2006

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow

scientific article published on 26 July 2009

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

scientific article published on 18 August 2014

Therapeutic antibodies against cancer stem cells: a promising approach

scientific article published on 24 August 2017

Truncated azinomycin analogues intercalate into DNA.

scientific article published on February 2005

Use of the hollow fiber assay for the evaluation of DNA damaging agents.

scientific article published on 30 April 2011

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